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    Hnrnpm heterogeneous nuclear ribonucleoprotein M [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116655, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hnrnpmprovided by RGD
    Official Full Name
    heterogeneous nuclear ribonucleoprotein Mprovided by RGD
    Primary source
    RGD:620369
    See related
    EnsemblRapid:ENSRNOG00000007921 AllianceGenome:RGD:620369
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hnrpm; Hnrpm4
    Summary
    Enables calcium-dependent protein binding activity and protein antigen binding activity. Involved in several processes, including cellular response to carcinoembryonic antigen; cellular response to lipopolysaccharide; and positive regulation of protein localization. Located in cell surface. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human HNRNPM (heterogeneous nuclear ribonucleoprotein M). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 226.8), Spleen (RPKM 161.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hnrnpm in Genome Data Viewer
    Location:
    7q13
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (15140877..15178871, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (14438703..14476781, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (18516253..18554536, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093540 Neighboring gene myosin IF Neighboring gene BAF nuclear assembly factor 1, pseudogene 1 Neighboring gene zinc finger protein 414 Neighboring gene PML-RARA regulated adaptor molecule 1 Neighboring gene membrane associated ring-CH-type finger 2 Neighboring gene RAB11B, member RAS oncogene family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The 72/74-kDa polypeptides of the 70-110 S large heterogeneous nuclear ribonucleoprotein complex (LH-nRNP) represent a discrete subset of the hnRNP M protein family. Kafasla P, et al. Biochem J, 2000 Sep 1. PMID 10947964, Free PMC Article
    2. A population of rat liver lysosomes responsible for the selective uptake and degradation of cytosolic proteins. Cuervo AM, et al. J Biol Chem, 1997 Feb 28. PMID 9038169
    3. Identification of HnRNP M as a novel biomarker for colorectal carcinoma by quantitative proteomics. Chen S, et al. Am J Physiol Gastrointest Liver Physiol, 2014 Mar 1. PMID 24381081
    4. Surface expression of heterogeneous nuclear RNA binding protein M4 on Kupffer cell relates to its function as a carcinoembryonic antigen receptor. Bajenova O, et al. Exp Cell Res, 2003 Nov 15. PMID 14597422
    5. Heterogeneous RNA-binding protein M4 is a receptor for carcinoembryonic antigen in Kupffer cells. Bajenova OV, et al. J Biol Chem, 2001 Aug 17. PMID 11406629

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109545

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables calcium-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein antigen binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to carcinoembryonic antigen IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein import IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of postsynapse organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynapse organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in paraspeckles ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    heterogeneous nuclear ribonucleoprotein M
    Names
    M4 protein
    hnRNP M

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109911.1 → NP_001103381.1  heterogeneous nuclear ribonucleoprotein M isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AY724543, BC088317, EV774465
      UniProtKB/TrEMBL
      A6KQH2
      Related
      ENSRNOP00000032108.5, ENSRNOT00000036172.8
      Conserved Domains (5) summary
      pfam11532
      Location:40 → 69
      HnRNP_M; Heterogeneous nuclear ribonucleoprotein M
      cd12657
      Location:71 → 146
      RRM1_hnRNPM; RNA recognition motif 1 (RRM1) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      cd12659
      Location:203 → 278
      RRM2_hnRNPM; RNA recognition motif 2 (RRM2) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      cd12661
      Location:653 → 729
      RRM3_hnRNPM; RNA recognition motif 3 (RRM3) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      NF033916
      Location:413 → 552
      antiphage_ZorA_3; anti-phage defense ZorAB system ZorA

    2. NM_053876.2 → NP_446328.2  heterogeneous nuclear ribonucleoprotein M isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame segment in the coding region, compared to variant 1, which results in shorter protein (isoform b) when compared to isoform a.
      Source sequence(s)
      BC088317, EV774465, U32577
      UniProtKB/Swiss-Prot
      Q5M815, Q62826
      Related
      ENSRNOP00000011047.6, ENSRNOT00000011047.9
      Conserved Domains (5) summary
      pfam11532
      Location:40 → 69
      HnRNP_M; Heterogeneous nuclear ribonucleoprotein M
      cd12657
      Location:71 → 146
      RRM1_hnRNPM; RNA recognition motif 1 (RRM1) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      cd12659
      Location:164 → 239
      RRM2_hnRNPM; RNA recognition motif 2 (RRM2) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      cd12661
      Location:614 → 690
      RRM3_hnRNPM; RNA recognition motif 3 (RRM3) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      NF033916
      Location:374 → 513
      antiphage_ZorA_3; anti-phage defense ZorAB system ZorA

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      15140877..15178871 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262870.1 → XP_063118940.1  heterogeneous nuclear ribonucleoprotein M isoform X2

      UniProtKB/TrEMBL
      A6KQH3

    2. XM_063262869.1 → XP_063118939.1  heterogeneous nuclear ribonucleoprotein M isoform X1

      UniProtKB/TrEMBL
      A6KQH3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62826.4 GenPept UniProtKB/Swiss-Prot:Q62826

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