Slc9a5 solute carrier family 9 member A5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc9a5provided by RGD
Official Full Name: solute carrier family 9 member A5provided by RGD
Primary source: RGD:620473
See related: EnsemblRapid:ENSRNOG00000028844 AllianceGenome:RGD:620473
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nhe5
Summary: Enables sodium:proton antiporter activity. Involved in proton transmembrane transport and sodium ion transmembrane transport. Predicted to be located in several cellular components, including focal adhesion; neuron spine; and recycling endosome membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in end stage renal disease. Orthologous to human SLC9A5 (solute carrier family 9 member A5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 36.8), Lung (RPKM 16.3) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (50135973..50156833)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (33225481..33246913)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (37304034..37325345)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NHE5 facilitates MET recycling to the plasma membrane, protects MET from degradation, and modulates HGF-induced phosphatidylinositol-3-kinase and mitogen-activated protein kinase signaling.
Title: Endosomal Na+/H+ exchanger NHE5 influences MET recycling and cell migration.
Data indicate that NHE5 depletion reduces cell surface abundance of TrkA and nerve growth factor (NGF)-induced PI3K signaling.
Title: Endosomal acidification by Na+/H+ exchanger NHE5 regulates TrkA cell-surface targeting and NGF-induced PI3K signaling.
these data suggest that NHE1, but not NHE5, plays an important role reducing inflammatory pain in rats.
Title: Identification of the Na+/H+ exchanger 1 in dorsal root ganglion and spinal cord: its possible role in inflammatory nociception.

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General gene information

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Markers

Slc9a5 (e-PCR), detects polymorphism
- UniSTS:547138

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables arrestin family protein binding	ISO Inferred from Sequence Orthology more info
enables potassium:proton antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:proton antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:proton antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium:proton antiporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in proton transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of intracellular pH	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of intracellular pH	ISO Inferred from Sequence Orthology more info
involved_in regulation of intracellular pH	ISS Inferred from Sequence or Structural Similarity more info
involved_in sodium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in dendritic spine membrane	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	ISS Inferred from Sequence or Structural Similarity more info
located_in neuron spine	ISO Inferred from Sequence Orthology more info
located_in neuron spine	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in recycling endosome membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in synapse	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: sodium/hydrogen exchanger 5

Names: NHE-5; Na(+)/H(+) exchanger 5; solute carrier family 9 (sodium/hydrogen exchanger), member 5; solute carrier family 9 member 5; solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138858.1 → NP_620213.1 sodium/hydrogen exchanger 5 precursor

See identical proteins and their annotated locations for NP_620213.1

Status: PROVISIONAL

Source sequence(s)

AF100172

UniProtKB/Swiss-Prot

G3V9Y4, Q9Z0X2

Related

ENSRNOP00000063061.1, ENSRNOT00000068299.3

Conserved Domains (2) summary

TIGR00840
Location:43 → 632

b_cpa1; sodium/hydrogen exchanger 3

pfam00999
Location:52 → 457

Na_H_Exchanger; Sodium/hydrogen exchanger family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

50135973..50156833

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017601171.3 → XP_017456660.1 sodium/hydrogen exchanger 5 isoform X1

UniProtKB/Swiss-Prot

G3V9Y4, Q9Z0X2
XM_039097459.2 → XP_038953387.1 sodium/hydrogen exchanger 5 isoform X3

Conserved Domains (1) summary

TIGR00840
Location:43 → 632

b_cpa1; sodium/hydrogen exchanger 3
XM_039097460.2 → XP_038953388.1 sodium/hydrogen exchanger 5 isoform X4

Conserved Domains (1) summary

TIGR00840
Location:43 → 622

b_cpa1; sodium/hydrogen exchanger 3
XM_039097458.2 → XP_038953386.1 sodium/hydrogen exchanger 5 isoform X2

UniProtKB/Swiss-Prot

G3V9Y4, Q9Z0X2

Conserved Domains (2) summary

TIGR00840
Location:3 → 570

b_cpa1; sodium/hydrogen exchanger 3

pfam03154
Location:734 → 821

Atrophin-1; Atrophin-1 family
XM_039097461.2 → XP_038953389.1 sodium/hydrogen exchanger 5 isoform X5

Conserved Domains (2) summary

TIGR00840
Location:1 → 335

b_cpa1; sodium/hydrogen exchanger 3

pfam03154
Location:499 → 586

Atrophin-1; Atrophin-1 family