Bex3 brain expressed X-linked 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bex3provided by RGD
Official Full Name: brain expressed X-linked 3provided by RGD
Primary source: RGD:3148
See related: EnsemblRapid:ENSRNOG00000028822 AllianceGenome:RGD:3148
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nade; Ngfrap1
Summary: Enables nerve growth factor receptor binding activity. Predicted to be involved in negative regulation of protein ubiquitination and signal transduction. Predicted to act upstream of or within extrinsic apoptotic signaling pathway via death domain receptors. Located in cytoplasm. Biomarker of glaucoma; transient cerebral ischemia; and visual epilepsy. Orthologous to human BEX3 (brain expressed X-linked 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 756.7), Brain (RPKM 676.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq32

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (104064896..104066425)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (99273270..99274799)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (106823442..106825016)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bex3 has an important role for the regulation of TrkA expression in neurons.
Title: Bex3 Dimerization Regulates NGF-Dependent Neuronal Survival and Differentiation by Enhancing trkA Gene Transcription.
Reducing neuronal p75NTR expression plays a critical role in switching satellite glial cells to a reactive state.
Title: Induction of a reactive state in perineuronal satellite glial cells akin to that produced by nerve injury is linked to the level of p75NTR expression in adult sensory neurons.
Expression of p75NTR increased in glia, but was downregulated in sensory neurons in sciatic nerve injury and spinal cord injury.
Title: [Expression and significance of p75NTR in dorsal root ganglia in different injury models].
hamartin binds to NADE to regulate neuronal cell function and loss of this association is likely to contribute to the brain pathology in tuberous sclerosis complex
Title: The TSC1 gene product hamartin interacts with NADE.
Expression of p75NTR on cholinergic interneurons of the rat striatum is associated with delayed neuronal degeneration.
Title: Expression of the p75 neurotrophin receptor by striatal cholinergic neurons following global ischemia in rats is associated with neuronal degeneration.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH128162 (e-PCR)
- UniSTS:211470

Ngfrap1 (e-PCR), detects polymorphism
- UniSTS:141173

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables death receptor binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular function inhibitor activity	ISO Inferred from Sequence Orthology more info
enables molecular function inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables nerve growth factor receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein BEX3

Names: brain-expressed X-linked protein 3 homolog; nerve growth factor receptor (TNFRSF16) associated protein 1; nerve growth factor receptor-associated protein 1; p75NTR-associated cell death executor; rBex3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398797.1 → NP_001385726.1 protein BEX3 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

Q6PDU5, Q9JIT2

Conserved Domains (1) summary

pfam04538
Location:1 → 126

BEX; Brain expressed X-linked like family
NM_053401.3 → NP_445853.1 protein BEX3 isoform 1

See identical proteins and their annotated locations for NP_445853.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

B2GUV1

Related

ENSRNOP00000042696.6, ENSRNOT00000045997.6

Conserved Domains (1) summary

pfam04538
Location:2 → 116

BEX; Brain expressed X-linked like family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

104064896..104066425

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039099417.2 → XP_038955345.1 protein BEX3 isoform X1

UniProtKB/Swiss-Prot

Q6PDU5, Q9JIT2

Related

ENSRNOP00000082465.2, ENSRNOT00000101693.2

Conserved Domains (1) summary

pfam04538
Location:1 → 126

BEX; Brain expressed X-linked like family
XM_039099418.2 → XP_038955346.1 protein BEX3 isoform X2

UniProtKB/TrEMBL

B2GUV1

Conserved Domains (1) summary

pfam04538
Location:2 → 116

BEX; Brain expressed X-linked like family