Prpsap1 phosphoribosyl pyrophosphate synthetase-associated protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prpsap1provided by RGD
Official Full Name: phosphoribosyl pyrophosphate synthetase-associated protein 1provided by RGD
Primary source: RGD:620206
See related: EnsemblRapid:ENSRNOG00000010083 AllianceGenome:RGD:620206
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables enzyme regulator activity and kinase binding activity. Involved in negative regulation of kinase activity. Part of ribose phosphate diphosphokinase complex. Orthologous to human PRPSAP1 (phosphoribosyl pyrophosphate synthetase associated protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 202.5), Adrenal (RPKM 164.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (102199949..102221642, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (101701094..101750753, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (105430516..105492154, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enzyme regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables enzyme regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 5-phosphoribose 1-diphosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in purine nucleotide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of ribose phosphate diphosphokinase complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: phosphoribosyl pyrophosphate synthase-associated protein 1

Names: 39 kDa phosphoribosypyrophosphate synthase-associated protein; 39 kDa phosphoribosypyrophosphate synthetase-associated protein; PAP39; PRPP synthase-associated protein 1; PRPP synthetase-associated protein 1; phosphoribosylpyrophosphate synthetase-associated protein (39 kDa)

NP_071990.2

EC 2.7.6.1

XP_038942719.1

EC 2.7.6.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022545.3 → NP_071990.2 phosphoribosyl pyrophosphate synthase-associated protein 1

See identical proteins and their annotated locations for NP_071990.2

Status: VALIDATED

Source sequence(s)

BC078822, CB736123

UniProtKB/Swiss-Prot

Q63417, Q63468

UniProtKB/TrEMBL

A6HKW7, G3V7B5, Q6AYZ7

Related

ENSRNOP00000013573.4, ENSRNOT00000013573.7

Conserved Domains (2) summary

pfam13793
Location:38 → 155

Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase

pfam14572
Location:196 → 379

Pribosyl_synth; Phosphoribosyl synthetase-associated domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

102199949..102221642 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039086791.2 → XP_038942719.1 phosphoribosyl pyrophosphate synthase-associated protein 1 isoform X1

UniProtKB/TrEMBL

A0A8I5ZZP2

Conserved Domains (2) summary

pfam13793
Location:1 → 52

Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase

pfam14572
Location:93 → 276

Pribosyl_synth; Phosphoribosyl synthetase-associated domain