Il20rb interleukin 20 receptor beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il20rbprovided by MGI
Official Full Name: interleukin 20 receptor betaprovided by MGI
Primary source: MGI:MGI:2143266
See related: Ensembl:ENSMUSG00000044244 AllianceGenome:MGI:2143266
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fndc6; Gm186; Il20R2
Summary: Enables interleukin-20 binding activity. Acts upstream of or within several processes, including CD8-positive, alpha-beta T cell homeostasis; negative regulation of type IV hypersensitivity; and regulation of cytokine production. Predicted to be active in plasma membrane. Is expressed in foregut; male reproductive gland or organ; metanephros; skin; and thymus. Orthologous to human IL20RB (interleukin 20 receptor subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cerebellum adult (RPKM 13.9), genital fat pad adult (RPKM 6.1) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 E3.3; 9 52.66 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (100339772..100368526, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (100457719..100486473, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Spinal interleukin-24 contributes to neuropathic pain after peripheral nerve injury through interleukin-20 receptor2 in mice.
Title: Spinal interleukin-24 contributes to neuropathic pain after peripheral nerve injury through interleukin-20 receptor2 in mice.
The IL-20RB receptor and the IL-20 signaling pathway in regulating host defense in oral mucosal candidiasis.
Title: The IL-20RB receptor and the IL-20 signaling pathway in regulating host defense in oral mucosal candidiasis.
IL-20R1 and IL-20R2 are constitutively express in the brain.
Title: Detection of IL-20R1 and IL-20R2 mRNA in C57BL/6 mice astroglial cells and brain cortex following LPS stimulation.
IL-20R2 regulates T cell activation directly and attenuates antigen-specific CD8 responses; IL-20R2 signaling directly regulates CD8 and CD4 T cell responses in vitro and in vivo.
Title: IL-20 receptor 2 signaling down-regulates antigen-specific T cell responses.
IL-20R2 receptor subunit is up-regulated by LPS in the liver of normal mice.
Title: The murine liver is a potential target organ for IL-19, IL-20 and IL-24: Type I Interferons and LPS regulate the expression of IL-20R2.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (5) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:487682

D9Dcr38 (e-PCR), detects polymorphism
- UniSTS:498955

AV228068 (e-PCR)
- UniSTS:165656

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-20 binding	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-20 binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within CD8-positive, alpha-beta T cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within T cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within homeostasis of number of cells within a tissue	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immune response-inhibiting signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inflammatory response to antigenic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of interleukin-10 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of interleukin-2 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of interleukin-4 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of interleukin-2 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of type IV hypersensitivity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-10 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-4 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of T cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: interleukin-20 receptor subunit beta

Names: fibronectin type III domain containing 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033543.3 → NP_001028715.2 interleukin-20 receptor subunit beta precursor

Status: VALIDATED

Source sequence(s)

AC134590, BE852308, BY772000, CK331954

Consensus CDS

CCDS23438.2

UniProtKB/TrEMBL

A0A142K3A7, E9Q9A6

Related

ENSMUSP00000096057.4, ENSMUST00000098458.4

Conserved Domains (2) summary

pfam01108
Location:28 → 119

Tissue_fac; Tissue factor

cl21522
Location:131 → 220

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

100339772..100368526 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001037246.1: Suppressed sequence

Description

NM_001037246.1: This RefSeq was permanently suppressed because it contains intronic sequence and the CDS is partial.