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    Adrb3 adrenergic receptor, beta 3 [ Mus musculus (house mouse) ]

    Gene ID: 11556, updated on 9-Dec-2024

    Summary

    Official Symbol
    Adrb3provided by MGI
    Official Full Name
    adrenergic receptor, beta 3provided by MGI
    Primary source
    MGI:MGI:87939
    See related
    Ensembl:ENSMUSG00000031489 AllianceGenome:MGI:87939
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Adrb-3; beta 3-AR
    Summary
    Enables beta-3 adrenergic receptor binding activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including brown fat cell differentiation; diet induced thermogenesis; and norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure. Located in membrane. Is expressed in central nervous system; early conceptus; oocyte; and retina. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); arthritis (multiple); dilated cardiomyopathy 1H; metabolic dysfunction-associated steatotic liver disease; and type 2 diabetes mellitus. Orthologous to human ADRB3 (adrenoceptor beta 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in mammary gland adult (RPKM 215.3), subcutaneous fat pad adult (RPKM 163.4) and 4 other tissues See more
    Orthologs
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    Genomic context

    See Adrb3 in Genome Data Viewer
    Location:
    8 A2; 8 15.94 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (27715804..27720833, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (27225776..27230845, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933416M07 gene Neighboring gene RAB11 family interacting protein 1 (class I) Neighboring gene glutamic-oxaloacetic transaminase 1-like 1 Neighboring gene STARR-seq mESC enhancer starr_21022 Neighboring gene STARR-seq mESC enhancer starr_21024 Neighboring gene predicted gene 45470 Neighboring gene STARR-seq mESC enhancer starr_21025 Neighboring gene eukaryotic translation initiation factor 4E binding protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables beta-3 adrenergic receptor binding PubMed 
    enables beta-adrenergic receptor activity  
    enables beta-adrenergic receptor activity  
    enables beta3-adrenergic receptor activity  
    enables beta3-adrenergic receptor activity  
    enables beta3-adrenergic receptor activity  
    enables epinephrine binding  
    enables epinephrine binding  
    enables epinephrine binding  
    contributes_to norepinephrine binding  
    enables norepinephrine binding  
    contributes_to norepinephrine binding  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    Process Evidence Code Pubs
    acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
    involved_in adenylate cyclase-activating adrenergic receptor signaling pathway  
    involved_in adenylate cyclase-activating adrenergic receptor signaling pathway  
    involved_in adenylate cyclase-activating adrenergic receptor signaling pathway  
    acts_upstream_of_or_within brown fat cell differentiation PubMed 
    acts_upstream_of_or_within diet induced thermogenesis PubMed 
    involved_in eating behavior  
    involved_in eating behavior  
    acts_upstream_of_or_within heat generation PubMed 
    acts_upstream_of_or_within negative regulation of multicellular organism growth PubMed 
    involved_in norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure  
    acts_upstream_of_or_within norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure PubMed 
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of cold-induced thermogenesis PubMed 
    involved_in positive regulation of cold-induced thermogenesis PubMed 
    acts_upstream_of_or_within response to cold PubMed 
    Component Evidence Code Pubs
    located_in membrane PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane  
    part_of receptor complex  
    part_of receptor complex  

    General protein information

    Preferred Names
    beta-3 adrenergic receptor
    Names
    Beta-3 AR
    beta-3 adrenoceptor
    beta-3 adrenoreceptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013462.3NP_038490.2  beta-3 adrenergic receptor

      See identical proteins and their annotated locations for NP_038490.2

      Status: VALIDATED

      Source sequence(s)
      AC102544
      Consensus CDS
      CCDS22213.1
      UniProtKB/Swiss-Prot
      A2RS74, P25962, Q9QZ98
      UniProtKB/TrEMBL
      Q3UP63
      Related
      ENSMUSP00000080162.4, ENSMUST00000081438.10
      Conserved Domains (2) summary
      cd14964
      Location:7092
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:48353
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      27715804..27720833 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243246.2XP_030099106.1  beta-3 adrenergic receptor isoform X1

      UniProtKB/Swiss-Prot
      A2RS74, P25962, Q9QZ98
      UniProtKB/TrEMBL
      Q3UP63
      Conserved Domains (2) summary
      cd14964
      Location:7092
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:48353
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    2. XM_030243247.2XP_030099107.1  beta-3 adrenergic receptor isoform X1

      UniProtKB/Swiss-Prot
      A2RS74, P25962, Q9QZ98
      UniProtKB/TrEMBL
      Q3UP63
      Related
      ENSMUSP00000113006.2, ENSMUST00000121838.2
      Conserved Domains (2) summary
      cd14964
      Location:7092
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:48353
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RNA

    1. XR_004934751.1 RNA Sequence

    2. XR_004934750.1 RNA Sequence

    3. XR_003947220.2 RNA Sequence

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