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    Klhl35 kelch-like 35 [ Mus musculus (house mouse) ]

    Gene ID: 72184, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Klhl35provided by MGI
    Official Full Name
    kelch-like 35provided by MGI
    Primary source
    MGI:MGI:1919434
    See related
    Ensembl:ENSMUSG00000035298 AllianceGenome:MGI:1919434
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810406K13Rik
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in diencephalon lateral wall ventricular layer; midbrain ventricular layer; pons ventricular layer; rest of cerebellum ventricular layer; and spinal cord ventricular layer. Orthologous to human KLHL35 (kelch like family member 35). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 7.2), whole brain E14.5 (RPKM 3.3) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Klhl35 in Genome Data Viewer
    Location:
    7 E1; 7 54.07 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (99112328..99123229)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (99463121..99474022)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_19650 Neighboring gene serine (or cysteine) peptidase inhibitor, clade H, member 1 Neighboring gene STARR-positive B cell enhancer ABC_E4952 Neighboring gene STARR-positive B cell enhancer ABC_E1346 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 5 Neighboring gene STARR-seq mESC enhancer starr_19652 Neighboring gene STARR-seq mESC enhancer starr_19653 Neighboring gene STARR-seq mESC enhancer starr_19654 Neighboring gene STARR-seq mESC enhancer starr_19655 Neighboring gene small nucleolar RNA, C/D box 15B Neighboring gene small nucleolar RNA, C/D box 15A Neighboring gene ribosomal protein S3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks. Xu G, et al. Mol Cell Proteomics, 2014 Feb. PMID 24319055, Free PMC Article
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 35

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028145.1 → NP_082421.1  kelch-like protein 35

      See identical proteins and their annotated locations for NP_082421.1

      Status: VALIDATED

      Source sequence(s)
      AK013012, BE994913, BM933902, BQ573536
      Consensus CDS
      CCDS52320.1
      UniProtKB/Swiss-Prot
      E9QMG1, Q9CZ49
      Related
      ENSMUSP00000041363.3, ENSMUST00000037359.9
      Conserved Domains (6) summary
      smart00612
      Location:386 → 432
      Kelch; Kelch domain
      smart00225
      Location:41 → 141
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00038
      Location:331 → 371
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:30 → 137
      BTB; BTB/POZ domain
      pfam01344
      Location:331 → 371
      Kelch_1; Kelch motif
      pfam07707
      Location:163 → 248
      BACK; BTB And C-terminal Kelch

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      99112328..99123229
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508220.4 → XP_006508283.1  kelch-like protein 35 isoform X1

      Conserved Domains (4) summary
      PHA03098
      Location:170 → 516
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:331 → 371
      Kelch; KELCH repeat [structural motif]
      cd18265
      Location:17 → 148
      BTB_POZ_KLHL35; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35)
      cl28903
      Location:171 → 254
      BACK; BACK (BTB and C-terminal Kelch) domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZ49.2 GenPept UniProtKB/Swiss-Prot:Q9CZ49

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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