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    Slc49a3 solute carrier family 49 member 3 [ Mus musculus (house mouse) ]

    Gene ID: 243197, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Slc49a3provided by MGI
    Official Full Name
    solute carrier family 49 member 3provided by MGI
    Primary source
    MGI:MGI:2442629
    See related
    Ensembl:ENSMUSG00000029490 AllianceGenome:MGI:2442629
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mfsd7; Mfsd7a; 4732482E20Rik
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Orthologous to human SLC49A3 (solute carrier family 49 member 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in stomach adult (RPKM 8.0), colon adult (RPKM 6.6) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc49a3 in Genome Data Viewer
    Location:
    5 F; 5 53.11 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (108588920..108598631, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (108441052..108450765, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide Neighboring gene predicted gene, 34254 Neighboring gene STARR-positive B cell enhancer ABC_E9648 Neighboring gene predicted gene, 34319 Neighboring gene ATP synthase membrane subunit e Neighboring gene STARR-positive B cell enhancer ABC_E6360 Neighboring gene polycomb group ring finger 3 Neighboring gene ribosomal protein L34 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 49 member A3
    Names
    major facilitator superfamily domain containing 7
    major facilitator superfamily domain containing 7A
    major facilitator superfamily domain-containing protein 7
    major facilitator superfamily domain-containing protein 7A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359977.1 → NP_001346906.1  solute carrier family 49 member A3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC158912
      Conserved Domains (1) summary
      cd06174
      Location:53 → 206
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

    2. NM_172883.3 → NP_766471.1  solute carrier family 49 member A3 isoform 1

      See identical proteins and their annotated locations for NP_766471.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK029021, AK087226
      Consensus CDS
      CCDS19511.1
      UniProtKB/Swiss-Prot
      Q505K1, Q8CE47
      Related
      ENSMUSP00000031455.4, ENSMUST00000031455.5
      Conserved Domains (2) summary
      cd06174
      Location:37 → 403
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:40 → 394
      MFS_1; Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      108588920..108598631 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534932.5 → XP_006534995.1  solute carrier family 49 member A3 isoform X2

      Conserved Domains (1) summary
      cl28910
      Location:32 → 392
      MFS; Major Facilitator Superfamily

    2. XM_006534933.5 → XP_006534996.1  solute carrier family 49 member A3 isoform X3

      Conserved Domains (1) summary
      cd17399
      Location:32 → 388
      MFS_MFSD7; Major facilitator superfamily domain-containing protein 7

    3. XM_036165127.1 → XP_036021020.1  solute carrier family 49 member A3 isoform X1

      Conserved Domains (1) summary
      cd17399
      Location:35 → 432
      MFS_MFSD7; Major facilitator superfamily domain-containing protein 7

    4. XM_006534934.4 → XP_006534997.1  solute carrier family 49 member A3 isoform X4

      Conserved Domains (1) summary
      cd17399
      Location:32 → 389
      MFS_MFSD7; Major facilitator superfamily domain-containing protein 7
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CE47.1 GenPept UniProtKB/Swiss-Prot:Q8CE47

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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