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    Mxra8 matrix-remodelling associated 8 [ Mus musculus (house mouse) ]

    Gene ID: 74761, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mxra8provided by MGI
    Official Full Name
    matrix-remodelling associated 8provided by MGI
    Primary source
    MGI:MGI:1922011
    See related
    Ensembl:ENSMUSG00000029070 AllianceGenome:MGI:1922011
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Asp3; Dicam; 1200013A08Rik; 1700095D18Rik
    Summary
    Involved in establishment of glial blood-brain barrier. Located in cell surface. Is expressed in brain ventricle and choroid plexus; cerebral cortex ventricular layer; heart valve; meninges; and skeleton. Orthologous to human MXRA8 (matrix remodeling associated 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in lung adult (RPKM 383.7), ovary adult (RPKM 167.8) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mxra8 in Genome Data Viewer
    Location:
    4 E2; 4 87.58 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (155924137..155928559)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (155839680..155844102)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3560 Neighboring gene cyclin L2 Neighboring gene STARR-seq mESC enhancer starr_12275 Neighboring gene STARR-positive B cell enhancer ABC_E4740 Neighboring gene STARR-positive B cell enhancer ABC_E8042 Neighboring gene aurora kinase A interacting protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E10297 Neighboring gene dishevelled segment polarity protein 1 Neighboring gene taste receptor, type 1, member 3 Neighboring gene STARR-positive B cell enhancer ABC_E1671 Neighboring gene ceramide-1-phosphate transfer protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ly6C(+) monocytes in the skin promote systemic alphavirus dissemination. Holmes AC, et al. Cell Rep, 2024 Mar 26. PMID 38446669, Free PMC Article
    2. Mxra8 is a receptor for multiple arthritogenic alphaviruses. Zhang R, et al. Nature, 2018 May. PMID 29769725, Free PMC Article
    3. Expression of the Mxra8 Receptor Promotes Alphavirus Infection and Pathogenesis in Mice and Drosophila. Zhang R, et al. Cell Rep, 2019 Sep 3. PMID 31484075, Free PMC Article
    4. Protective Role of Limitrin in Experimental Autoimmune Optic Neuritis. Chun BY, et al. Invest Ophthalmol Vis Sci, 2021 Jul 1. PMID 34232258, Free PMC Article
    5. Gene expression profile of human chondrocyte HCS-2/8 cell line by EST sequencing analysis. Jung YK, et al. Gene, 2004 Apr 14. PMID 15087127

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Role of MXRA8 in Ross River Virus Disease Pathogenesis.
      Title: Role of MXRA8 in Ross River Virus Disease Pathogenesis.
    2. DICAM in the Extracellular Vesicles from Astrocytes Attenuates Microglia Activation and Neuroinflammation.
      Title: DICAM in the Extracellular Vesicles from Astrocytes Attenuates Microglia Activation and Neuroinflammation.
    3. Matrix remodeling-associated protein 8 is a marker of a subset of cancer-associated fibroblasts in pancreatic cancer.
      Title: Matrix remodeling-associated protein 8 is a marker of a subset of cancer-associated fibroblasts in pancreatic cancer.
    4. Protective Role of Limitrin in Experimental Autoimmune Optic Neuritis.
      Title: Protective Role of Limitrin in Experimental Autoimmune Optic Neuritis.
    5. Expression of the Mxra8 Receptor Promotes Alphavirus Infection and Pathogenesis in Mice and Drosophila.
      Title: Expression of the Mxra8 Receptor Promotes Alphavirus Infection and Pathogenesis in Mice and Drosophila.
    6. Mxra8 bound directly to chikungunya virus particles and enhanced virus attachment and internalization into cells
      Title: Mxra8 is a receptor for multiple arthritogenic alphaviruses.
    7. These results indicate that DICAM acts as a negative regulator of osteoclast differentiation by suppressing the integrin alphaVbeta3 pathway.[DICAM]
      Title: DICAM inhibits osteoclast differentiation through attenuation of the integrin αVβ3 pathway.
    8. DICAM suppressed angiogenesis by attenuating AKT and p38 MAP kinase signalling.
      Title: DICAM inhibits angiogenesis via suppression of AKT and p38 MAP kinase signalling.
    9. Results indicate that DICAM, a novel dual Ig domain containing adhesion molecule, mediates cell adhesion via alphavbeta3 integrin.
      Title: DICAM, a novel dual immunoglobulin domain containing cell adhesion molecule interacts with alphavbeta3 integrin.
    10. new member of the transmembrane-type immunoglobulin superfamily and designated limitrin, localizing selectively to glia limitans in mouse brain
      Title: Limitrin, a novel immunoglobulin superfamily protein localized to glia limitans formed by astrocyte endfeet.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6)  1 citation
    • Gene trapped (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC3047

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of glial blood-brain barrier IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    matrix remodeling-associated protein 8
    Names
    adipocyte-specific protein 3
    dual Ig domain containing cell adhesion molecule
    limitrin
    matrix-remodeling-associated protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024263.4 → NP_077225.4  matrix remodeling-associated protein 8 precursor

      See identical proteins and their annotated locations for NP_077225.4

      Status: VALIDATED

      Source sequence(s)
      AK004732, AL670236, BQ033722
      Consensus CDS
      CCDS19044.1
      UniProtKB/Swiss-Prot
      Q76M97, Q920S7, Q9DBV4
      Related
      ENSMUSP00000030947.4, ENSMUST00000030947.4
      Conserved Domains (1) summary
      pfam07686
      Location:171 → 291
      V-set; Immunoglobulin V-set domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      155924137..155928559
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539235.4 → XP_006539298.1  matrix remodeling-associated protein 8 isoform X1

      Conserved Domains (1) summary
      pfam07686
      Location:168 → 288
      V-set; Immunoglobulin V-set domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DBV4.1 GenPept UniProtKB/Swiss-Prot:Q9DBV4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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