Ppp2r5b protein phosphatase 2, regulatory subunit B', beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppp2r5bprovided by MGI
Official Full Name: protein phosphatase 2, regulatory subunit B', betaprovided by MGI
Primary source: MGI:MGI:2388480
See related: Ensembl:ENSMUSG00000024777 AllianceGenome:MGI:2388480
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B'beta
Summary: Predicted to enable protein phosphatase activator activity. Predicted to be involved in protein dephosphorylation. Predicted to act upstream of or within several processes, including positive regulation of cellular component organization; regulation of DNA-templated transcription; and regulation of protein phosphorylation. Predicted to be located in cytoplasm. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including gonad; gut; hemolymphoid system gland; nervous system; and sensory organ. Orthologous to human PPP2R5B (protein phosphatase 2 regulatory subunit B'beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 89.9), cerebellum adult (RPKM 51.2) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 4.35 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (6277795..6286294, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (6227765..6236264, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PPP2R5B, a B subunit of PP2A is a negative regulator of Akt phosphorylation contributing partly to the chronic hyperinsulinemia induced insulin resistance in adipocytes.
Title: PPP2R5B, a regulatory subunit of PP2A, contributes to adipocyte insulin resistance.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ppp2r5b (e-PCR), detects polymorphism
- UniSTS:527062

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein phosphatase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to growth factor stimulus	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within negative regulation of G0 to G1 transition	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within positive regulation of neurotrophin TRK receptor signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within positive regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within regulation of cell cycle	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within regulation of protein autophosphorylation	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within regulation of signaling receptor activity	ISO Inferred from Sequence Orthology more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of protein phosphatase type 2A complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein phosphatase type 2A complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198168.3 → NP_937811.1 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform

See identical proteins and their annotated locations for NP_937811.1

Status: VALIDATED

Source sequence(s)

AK171178

Consensus CDS

CCDS29499.1

UniProtKB/Swiss-Prot

Q3V3S8, Q6PD28, Q8R342

Related

ENSMUSP00000025695.10, ENSMUST00000025695.10

Conserved Domains (1) summary

pfam01603
Location:69 → 467

B56; Protein phosphatase 2A regulatory B subunit (B56 family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

6277795..6286294 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161520.1 → XP_036017413.1 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1

UniProtKB/Swiss-Prot

Q3V3S8, Q6PD28, Q8R342

Conserved Domains (1) summary

pfam01603
Location:69 → 467

B56; Protein phosphatase 2A regulatory B subunit (B56 family)
XM_030250869.1 → XP_030106729.1 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X2

Conserved Domains (1) summary

pfam01603
Location:1 → 381

B56; Protein phosphatase 2A regulatory B subunit (B56 family)