Batf2 basic leucine zipper transcription factor, ATF-like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Batf2provided by MGI
Official Full Name: basic leucine zipper transcription factor, ATF-like 2provided by MGI
Primary source: MGI:MGI:1921731
See related: Ensembl:ENSMUSG00000039699 AllianceGenome:MGI:1921731
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B-ATF-2
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in defense response to protozoan and myeloid dendritic cell differentiation. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Is expressed in brain; central nervous system; dorsal root ganglion; lung; and spinal cord. Orthologous to human BATF2 (basic leucine zipper ATF-like transcription factor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in large intestine adult (RPKM 36.2), duodenum adult (RPKM 28.4) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 4.34 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (6214424..6222506)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (6164397..6172476)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BATF2 enhances proinflammatory cytokine responses in macrophages and improves early host defense against pulmonary Klebsiella pneumoniae infection.
Title: BATF2 enhances proinflammatory cytokine responses in macrophages and improves early host defense against pulmonary Klebsiella pneumoniae infection.
BATF2 inhibits PD-L1 expression and regulates CD8+ T-cell infiltration in non-small cell lung cancer.
Title: BATF2 inhibits PD-L1 expression and regulates CD8+ T-cell infiltration in non-small cell lung cancer.
SARI suppresses colitis-associated cancer development by maintaining MCP-1-mediated tumour-associated macrophage recruitment.
Title: SARI suppresses colitis-associated cancer development by maintaining MCP-1-mediated tumour-associated macrophage recruitment.
SARI prevents ocular angiogenesis and inflammation in mice.
Title: SARI prevents ocular angiogenesis and inflammation in mice.
SARI attenuated colitis in mice by impairing colitis-dependent STAT1/CCL2 transcriptional activation in IECs and macrophages recruitment in colon tissue.
Title: SARI attenuates colon inflammation by promoting STAT1 degradation in intestinal epithelial cells.
this study shows that BATF2 prevents T-cell-mediated intestinal inflammation through regulation of the IL-23/IL-17 pathway
Title: BATF2 prevents T-cell-mediated intestinal inflammation through regulation of the IL-23/IL-17 pathway.
BATF2 activates DUSP2 gene expression and up-regulates NF-kappaB activity via phospho-STAT3 dephosphorylation
Title: BATF2 activates DUSP2 gene expression and up-regulates NF-κB activity via phospho-STAT3 dephosphorylation.
these data reveal a regulatory role of Batf2 on the host immune responses to Type 1 (tuberculosis and listeriosis) and Type 2 (schistosomiasis) diseases
Title: Batf2 differentially regulates tissue immunopathology in Type 1 and Type 2 diseases.
Gain- and loss-of-function studies uncovered a role for Batf2 in myeloid differentiation in both murine and human systems. We thus demonstrate that chronic infection can deplete HSPCs and identify BATF2 as a mediator of infection-induced HSPC terminal differentiation
Title: Chronic Infection Depletes Hematopoietic Stem Cells through Stress-Induced Terminal Differentiation.
controls Th17-mediated immunopathology by suppressing IL-23 production during Trypanosoma cruzi infection
Title: BATF2 inhibits immunopathological Th17 responses by suppressing Il23a expression during Trypanosoma cruzi infection.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (4) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in defense response to protozoan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myeloid dendritic cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IEA Inferred from Electronic Annotation more info
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: basic leucine zipper transcriptional factor ATF-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356604.1 → NP_001343533.1 basic leucine zipper transcriptional factor ATF-like 2 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC131114

Consensus CDS

CCDS89321.1

Related

ENSMUSP00000158113.2, ENSMUST00000237511.2

Conserved Domains (2) summary

cd14686
Location:28 → 71

bZIP; coiled coil [structural motif]

cl21462
Location:28 → 73

bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
NM_001379529.1 → NP_001366458.1 basic leucine zipper transcriptional factor ATF-like 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC131114

Conserved Domains (1) summary

cd14701
Location:25 → 71

bZIP_BATF; Basic leucine zipper (bZIP) domain of BATF proteins: a DNA-binding and dimerization domain
NM_028967.2 → NP_083243.1 basic leucine zipper transcriptional factor ATF-like 2 isoform 1

See identical proteins and their annotated locations for NP_083243.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1)

Source sequence(s)

AC131114, CJ134251

Consensus CDS

CCDS29497.1

UniProtKB/Swiss-Prot

Q3TAI2, Q8R1H8

Related

ENSMUSP00000045744.8, ENSMUST00000045042.8

Conserved Domains (1) summary

cd14701
Location:28 → 74

bZIP_BATF; Basic leucine zipper (bZIP) domain of BATF proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

6214424..6222506

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017318301.3 → XP_017173790.1 basic leucine zipper transcriptional factor ATF-like 2 isoform X1

Conserved Domains (1) summary

cd14701
Location:25 → 71

bZIP_BATF; Basic leucine zipper (bZIP) domain of BATF proteins: a DNA-binding and dimerization domain