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    Klhl14 kelch-like 14 [ Mus musculus (house mouse) ]

    Gene ID: 225266, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Klhl14provided by MGI
    Official Full Name
    kelch-like 14provided by MGI
    Primary source
    MGI:MGI:1921249
    See related
    Ensembl:ENSMUSG00000042514 AllianceGenome:MGI:1921249
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    printor; 6330403N15Rik
    Summary
    Located in neuron projection and neuronal cell body. Is expressed in several structures, including central nervous system; endocrine gland; metanephros; sensory organ; and thymus primordium. Orthologous to human KLHL14 (kelch like family member 14). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in adrenal adult (RPKM 16.7), genital fat pad adult (RPKM 4.1) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Klhl14 in Genome Data Viewer
    Location:
    18 A2; 18 11.96 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (21683436..21805986, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (21550379..21672929, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_44013 Neighboring gene STARR-seq mESC enhancer starr_44015 Neighboring gene predicted gene, 22886 Neighboring gene STARR-seq mESC enhancer starr_44016 Neighboring gene predicted gene, 31646 Neighboring gene pyruvate kinase, muscle pseudogene Neighboring gene STARR-seq mESC enhancer starr_44017 Neighboring gene STARR-seq mESC enhancer starr_44018 Neighboring gene RIKEN cDNA 4930426D05 gene Neighboring gene STARR-seq mESC enhancer starr_44019 Neighboring gene coiled coil domain containing 178 Neighboring gene STARR-seq mESC enhancer starr_44020 Neighboring gene STARR-seq mESC enhancer starr_44021 Neighboring gene STARR-seq mESC enhancer starr_44023 Neighboring gene STARR-seq mESC enhancer starr_44024 Neighboring gene ribosomal protein SA pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Kelch-like protein 14 promotes B-1a but suppresses B-1b cell development. Li S, et al. Int Immunol, 2018 Jun 26. PMID 29939266
    2. Crim1 and Kelch-like 14 exert complementary dual-directional developmental control over segmentally specific corticospinal axon projection targeting. Sahni V, et al. Cell Rep, 2021 Oct 19. PMID 34686337, Free PMC Article
    3. Printor, a novel torsinA-interacting protein implicated in dystonia pathogenesis. Giles LM, et al. J Biol Chem, 2009 Aug 7. PMID 19535332, Free PMC Article
    4. A Role for Dystonia-Associated Genes in Spinal GABAergic Interneuron Circuitry. Zhang J, et al. Cell Rep, 2017 Oct 17. PMID 29045835, Free PMC Article
    5. Genome-wide expression analysis of Ptf1a- and Ascl1-deficient mice reveals new markers for distinct dorsal horn interneuron populations contributing to nociceptive reflex plasticity. Wildner H, et al. J Neurosci, 2013 Apr 24. PMID 23616538, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Crim1 and Kelch-like 14 exert complementary dual-directional developmental control over segmentally specific corticospinal axon projection targeting.
      Title: Crim1 and Kelch-like 14 exert complementary dual-directional developmental control over segmentally specific corticospinal axon projection targeting.
    2. KLHL14 promotes B-1a development in mice
      Title: Kelch-like protein 14 promotes B-1a but suppresses B-1b cell development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in aggresome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in aggresome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kelch-like protein 14
    Names
    protein interactor of Torsin-1A
    protein interactor of torsinA

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081403.2 → NP_001074872.1  kelch-like protein 14

      See identical proteins and their annotated locations for NP_001074872.1

      Status: VALIDATED

      Source sequence(s)
      AC140283, AC158903
      Consensus CDS
      CCDS37748.1
      UniProtKB/Swiss-Prot
      Q69ZK5, Q9CU51
      Related
      ENSMUSP00000113755.2, ENSMUST00000122333.2
      Conserved Domains (4) summary
      PHA03098
      Location:140 → 602
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:365 → 412
      Kelch; KELCH repeat [structural motif]
      cd18243
      Location:1 → 190
      BTB_POZ_KLHL14_printor; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14)
      cd18453
      Location:183 → 284
      BACK_KLHL14; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      21683436..21805986 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525823.4 → XP_006525886.1  kelch-like protein 14 isoform X1

      See identical proteins and their annotated locations for XP_006525886.1

      UniProtKB/Swiss-Prot
      Q69ZK5, Q9CU51
      Related
      ENSMUSP00000042015.5, ENSMUST00000049105.11
      Conserved Domains (4) summary
      PHA03098
      Location:140 → 602
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:365 → 412
      Kelch; KELCH repeat [structural motif]
      cd18243
      Location:1 → 190
      BTB_POZ_KLHL14_printor; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14)
      cd18453
      Location:183 → 284
      BACK_KLHL14; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q69ZK5.2 GenPept UniProtKB/Swiss-Prot:Q69ZK5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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