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    Commd10 COMM domain containing 10 [ Mus musculus (house mouse) ]

    Gene ID: 69456, updated on 10-Dec-2024

    Summary

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    Official Symbol
    Commd10provided by MGI
    Official Full Name
    COMM domain containing 10provided by MGI
    Primary source
    MGI:MGI:1916706
    See related
    Ensembl:ENSMUSG00000042705 AllianceGenome:MGI:1916706
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DRWMS2; VavCre; Vav-cre; Vav-iCre; Vav1-Cre; 2310003A05Rik; Tg(Vav1-icre)A2Kio
    Summary
    Predicted to be located in nucleoplasm. Orthologous to human COMMD10 (COMM domain containing 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 9.6), CNS E11.5 (RPKM 9.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Commd10 in Genome Data Viewer
    Location:
    18 C; 18 24.9 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (47091917..47242435)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (46958819..47087995)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene 3744 Neighboring gene STARR-positive B cell enhancer ABC_E5655 Neighboring gene predicted gene, 49974 Neighboring gene predicted gene, 22791 Neighboring gene STARR-positive B cell enhancer mm9_chr18:47157285-47157586 Neighboring gene STARR-seq mESC enhancer starr_44533 Neighboring gene heat shock protein 1 (chaperonin 10), related sequence 1 Neighboring gene ADP-ribosylation factor interacting protein 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Promoter elements of vav drive transgene expression in vivo throughout the hematopoietic compartment. Ogilvy S, et al. Blood, 1999 Sep 15. PMID 10477714
    2. Single-cell RNA sequencing of a new transgenic t(8;21) preleukemia mouse model reveals regulatory networks promoting leukemic transformation. Yan M, et al. Leukemia, 2024 Jan. PMID 37838757, Free PMC Article
    3. COMMD10 Is Essential for Neural Plate Development during Embryogenesis. Phan KP, et al. J Dev Biol, 2023 Mar 16. PMID 36976102, Free PMC Article
    4. Deciphering hematopoietic stem cells in their niches: a critical appraisal of genetic models, lineage tracing, and imaging strategies. Joseph C, et al. Cell Stem Cell, 2013 Nov 7. PMID 24209759
    5. Rheb1-Deficient Neutrophils Promote Hematopoietic Stem/Progenitor Cell Proliferation via Mesenchymal Stem Cells. Gao J, et al. Front Cell Dev Biol, 2021. PMID 34124040, Free PMC Article

    See all (610) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ERAdP-mediated production of pro-inflammatory cytokines is critical for controlling bacterial infection
      Title: The ER membrane adaptor ERAdP senses the bacterial second messenger c-di-AMP and initiates anti-bacterial immunity.
    2. COMMD10 inhibits HIF1alpha/CP loop to enhance ferroptosis and radiosensitivity by disrupting Cu-Fe balance in hepatocellular carcinoma.
      Title: COMMD10 inhibits HIF1α/CP loop to enhance ferroptosis and radiosensitivity by disrupting Cu-Fe balance in hepatocellular carcinoma.
    3. COMMD10 is critical for Kupffer cell survival and controls Ly6C(hi) monocyte differentiation and inflammation in the injured liver.
      Title: COMMD10 is critical for Kupffer cell survival and controls Ly6C(hi) monocyte differentiation and inflammation in the injured liver.
    4. Expression profile and bioinformatics analysis of COMMD10 in BALB/C mice and human.
      Title: Expression profile and bioinformatics analysis of COMMD10 in BALB/C mice and human.
    5. these results highlight COMMD10 as a negative regulator of Ly6Chi monocyte inflammasome activity during systemic inflammation
      Title: Impaired COMMD10-Mediated Regulation of Ly6C(hi) Monocyte-Driven Inflammation Disrupts Gut Barrier Function.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    COMM domain-containing protein 10
    Names
    Tg(Vav1-cre)1Kio
    Tg(Vav1-cre)A2Kio
    down-regulated in W/WV mouse stomach 2
    mDRWMS2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418791.1 → NP_001405720.1  COMM domain-containing protein 10 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC117239, AC132100

    2. NM_001418792.1 → NP_001405721.1  COMM domain-containing protein 10 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC117239, AC132100

    3. NM_001418808.1 → NP_001405737.1  COMM domain-containing protein 10 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC117239, AC132100
      UniProtKB/TrEMBL
      A0A3Q4EHW7, Q3UTM6
      Related
      ENSMUSP00000157148.2, ENSMUST00000234961.2

    4. NM_001418809.1 → NP_001405738.1  COMM domain-containing protein 10 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC132100
      UniProtKB/TrEMBL
      Q3UTM6
      Related
      ENSMUSP00000157292.2, ENSMUST00000234124.2

    5. NM_001418810.1 → NP_001405739.1  COMM domain-containing protein 10 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC117239, AC132100
      UniProtKB/TrEMBL
      A0A3Q4EC50
      Related
      ENSMUSP00000157272.2, ENSMUST00000234701.2

    6. NM_001418811.1 → NP_001405740.1  COMM domain-containing protein 10 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC117239, AC132100

    7. NM_001418812.1 → NP_001405741.1  COMM domain-containing protein 10 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC117239, AC132100

    8. NM_001418813.1 → NP_001405742.1  COMM domain-containing protein 10 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC117239, AC132100
      UniProtKB/TrEMBL
      A0A3Q4EII3
      Related
      ENSMUSP00000157358.2, ENSMUST00000234280.2

    9. NM_001418814.1 → NP_001405743.1  COMM domain-containing protein 10 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC117239, AC132100

    10. NM_001418815.1 → NP_001405744.1  COMM domain-containing protein 10 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC117239, AC132100
      UniProtKB/TrEMBL
      A0A3Q4EGT0
      Related
      ENSMUSP00000157146.2, ENSMUST00000234085.2

    11. NM_001418816.1 → NP_001405745.1  COMM domain-containing protein 10 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC117239, AC132100

    12. NM_001418817.1 → NP_001405746.1  COMM domain-containing protein 10 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC117239, AC132100

    13. NM_178377.5 → NP_848464.1  COMM domain-containing protein 10 isoform 1

      See identical proteins and their annotated locations for NP_848464.1

      Status: VALIDATED

      Source sequence(s)
      AC117239, AC132100
      Consensus CDS
      CCDS29238.1
      UniProtKB/Swiss-Prot
      Q8JZY2
      UniProtKB/TrEMBL
      Q3TKN7, Q3UTM6
      Related
      ENSMUSP00000041650.8, ENSMUST00000049388.9
      Conserved Domains (1) summary
      cd04758
      Location:15 → 201
      Commd10; COMM_Domain containing protein 10. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...

    RNA

    1. NR_184828.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC117239, AC132100

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      47091917..47242435
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8JZY2.1 GenPept UniProtKB/Swiss-Prot:Q8JZY2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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