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    Gtf2f2 general transcription factor IIF, polypeptide 2 [ Mus musculus (house mouse) ]

    Gene ID: 68705, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gtf2f2provided by MGI
    Official Full Name
    general transcription factor IIF, polypeptide 2provided by MGI
    Primary source
    MGI:MGI:1915955
    See related
    Ensembl:ENSMUSG00000067995 AllianceGenome:MGI:1915955
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TFIIF-beta; 1110031C13Rik
    Summary
    Predicted to enable RNA polymerase II general transcription initiation factor activity. Predicted to be involved in RNA polymerase II preinitiation complex assembly; positive regulation of transcription by RNA polymerase II; and transcription elongation by RNA polymerase II. Predicted to be located in microtubule cytoskeleton and nucleoplasm. Predicted to be part of transcription factor TFIIF complex and transcription factor TFIIH holo complex. Is expressed in genitourinary system. Orthologous to human GTF2F2 (general transcription factor IIF subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 11.1), placenta adult (RPKM 10.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gtf2f2 in Genome Data Viewer
    Location:
    14 D3; 14 40.29 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (76134368..76248356, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (75896928..76010865, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37150 Neighboring gene small nucleolar RNA, H/ACA box 31 Neighboring gene tumor protein, translationally-controlled 1 Neighboring gene STARR-positive B cell enhancer ABC_E10835 Neighboring gene predicted gene, 52138 Neighboring gene STARR-seq mESC enhancer starr_37153 Neighboring gene armadillo repeat containing 10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_37154 Neighboring gene potassium channel tetramerisation domain containing 4 Neighboring gene predicted gene, 53845 Neighboring gene predicted gene, 25517 Neighboring gene STARR-seq mESC enhancer starr_37156 Neighboring gene predicted gene, 36429 Neighboring gene predicted gene, 36477 Neighboring gene STARR-seq mESC enhancer starr_37162 Neighboring gene STARR-seq mESC enhancer starr_37163 Neighboring gene STARR-seq mESC enhancer starr_37165 Neighboring gene GPALPP motifs containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TFIIF facilitates dissociation of RNA polymerase II from noncoding RNAs that lack a repression domain. Wagner SD, et al. Mol Cell Biol, 2010 Jan. PMID 19841064, Free PMC Article
    2. The murine G+C-rich promoter binding protein mGPBP is required for promoter-specific transcription. Hsu LC, et al. Mol Cell Biol, 2003 Dec. PMID 14612417, Free PMC Article
    3. Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria. Kamileri I, et al. Proc Natl Acad Sci U S A, 2012 Feb 21. PMID 22323595, Free PMC Article
    4. Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment. Georgas K, et al. Dev Biol, 2009 Aug 15. PMID 19501082
    5. Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain. Lee Y, et al. Biochem Biophys Res Commun, 2020 Aug 13. PMID 32560809

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II general transcription initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables forked DNA-dependent helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables four-way junction helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded 3'-5' DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA polymerase II preinitiation complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transcription elongation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in microtubule cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIIF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIF complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIIH holo complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    general transcription factor IIF subunit 2
    Names
    ATP-dependent helicase GTF2F2
    transcription initiation factor IIF subunit beta
    NP_001405473.1
    NP_001405474.1
    NP_081092.1
    XP_030103845.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418544.1 → NP_001405473.1  general transcription factor IIF subunit 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC122192, AC140244

    2. NM_001418545.1 → NP_001405474.1  general transcription factor IIF subunit 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122192, AC140244

    3. NM_026816.4 → NP_081092.1  general transcription factor IIF subunit 2 isoform 1

      See identical proteins and their annotated locations for NP_081092.1

      Status: VALIDATED

      Source sequence(s)
      AC122192, AC140244
      Consensus CDS
      CCDS36981.1
      UniProtKB/Swiss-Prot
      Q8R0A0
      UniProtKB/TrEMBL
      Q3UMJ4
      Related
      ENSMUSP00000086312.5, ENSMUST00000088922.5
      Conserved Domains (1) summary
      pfam02270
      Location:13 → 236
      TFIIF_beta; Transcription initiation factor IIF, beta subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      76134368..76248356 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247985.1 → XP_030103845.1  general transcription factor IIF subunit 2 isoform X1

      Conserved Domains (1) summary
      pfam02270
      Location:52 → 116
      TFIIF_beta; Transcription initiation factor IIF, beta subunit
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R0A0.1 GenPept UniProtKB/Swiss-Prot:Q8R0A0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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