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    Sncg synuclein, gamma [ Mus musculus (house mouse) ]

    Gene ID: 20618, updated on 10-Dec-2024

    Summary

    Official Symbol
    Sncgprovided by MGI
    Official Full Name
    synuclein, gammaprovided by MGI
    Primary source
    MGI:MGI:1298397
    See related
    Ensembl:ENSMUSG00000023064 AllianceGenome:MGI:1298397
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    persyn
    Summary
    Predicted to enable alpha-tubulin binding activity; beta-tubulin binding activity; and cuprous ion binding activity. Involved in protein secretion. Acts upstream of or within several processes, including adult locomotory behavior; chemical synaptic transmission; and regulation of secretion by cell. Located in axon; cytoplasm; and neuronal cell body. Is expressed in several structures, including adipose tissue; alimentary system; central nervous system; hemolymphoid system gland; and sensory organ. Used to study amyotrophic lateral sclerosis type 1. Human ortholog(s) of this gene implicated in Lewy body dementia. Orthologous to human SNCG (synuclein gamma). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in subcutaneous fat pad adult (RPKM 361.5), genital fat pad adult (RPKM 239.2) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Sncg in Genome Data Viewer
    Location:
    14 B; 14 20.81 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (34092231..34096626, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (34370274..34374669, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_36378 Neighboring gene predicted gene, 53843 Neighboring gene predicted gene, 41131 Neighboring gene STARR-seq mESC enhancer starr_36379 Neighboring gene multimerin 2 Neighboring gene STARR-seq mESC enhancer starr_36380 Neighboring gene bone morphogenetic protein receptor, type 1A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-tubulin binding  
    enables beta-tubulin binding  
    enables cuprous ion binding  
    enables protein binding PubMed 
    Component Evidence Code Pubs
    located_in axon PubMed 
    is_active_in axon terminus  
    located_in axon terminus  
    located_in centrosome  
    located_in centrosome  
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    is_active_in neuronal cell body  
    located_in neuronal cell body PubMed 
    located_in neuronal cell body  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    located_in spindle  
    located_in synapse  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011430.3NP_035560.1  gamma-synuclein

      See identical proteins and their annotated locations for NP_035560.1

      Status: VALIDATED

      Source sequence(s)
      AA690669, BC028508
      Consensus CDS
      CCDS26937.1
      UniProtKB/Swiss-Prot
      Q9Z0F7
      UniProtKB/TrEMBL
      Q5GQ64
      Related
      ENSMUSP00000023826.5, ENSMUST00000023826.5
      Conserved Domains (1) summary
      pfam01387
      Location:1105
      Synuclein; Synuclein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      34092231..34096626 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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