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    Lif leukemia inhibitory factor [ Mus musculus (house mouse) ]

    Gene ID: 16878, updated on 4-Jan-2025

    Summary

    Official Symbol
    Lifprovided by MGI
    Official Full Name
    leukemia inhibitory factorprovided by MGI
    Primary source
    MGI:MGI:96787
    See related
    Ensembl:ENSMUSG00000034394 AllianceGenome:MGI:96787
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables cytokine activity and growth factor activity. Acts upstream of or within several processes, including cell differentiation involved in embryonic placenta development; lung development; and positive regulation of macromolecule biosynthetic process. Located in extracellular space. Is expressed in several structures, including alimentary system; early conceptus; hemolymphoid system; nervous system; and reproductive system. Orthologous to human LIF (LIF interleukin 6 family cytokine). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See Lif in Genome Data Viewer
    Location:
    11 A1; 11 2.94 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (4207587..4222514)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (4257568..4272514)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11956 Neighboring gene STARR-seq mESC enhancer starr_28372 Neighboring gene oncostatin M Neighboring gene STARR-seq mESC enhancer starr_28375 Neighboring gene predicted gene 11959 Neighboring gene predicted gene 11958 Neighboring gene predicted gene, 53662

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity  
    enables cytokine activity PubMed 
    enables cytokine activity  
    enables growth factor activity  
    enables growth factor activity PubMed 
    enables growth factor activity  
    enables leukemia inhibitory factor receptor binding  
    enables leukemia inhibitory factor receptor binding PubMed 
    enables signaling receptor binding  
    Items 1 - 25 of 67
    Process Evidence Code Pubs
    involved_in animal organ regeneration  
    involved_in astrocyte differentiation  
    acts_upstream_of_or_within blood vessel remodeling PubMed 
    acts_upstream_of_or_within cell morphogenesis PubMed 
    acts_upstream_of cell population proliferation PubMed 
    involved_in cell surface receptor signaling pathway via STAT  
    involved_in cell surface receptor signaling pathway via STAT  
    acts_upstream_of_or_within decidualization PubMed 
    acts_upstream_of_or_within decidualization PubMed 
    acts_upstream_of_or_within embryo implantation PubMed 
    acts_upstream_of_or_within embryo implantation PubMed 
    acts_upstream_of fibroblast proliferation PubMed 
    acts_upstream_of_or_within gene expression PubMed 
    involved_in immune response  
    involved_in leukemia inhibitory factor signaling pathway  
    involved_in leukemia inhibitory factor signaling pathway  
    involved_in leukemia inhibitory factor signaling pathway  
    acts_upstream_of_or_within lung alveolus development PubMed 
    acts_upstream_of_or_within lung development PubMed 
    acts_upstream_of_or_within lung lobe morphogenesis PubMed 
    acts_upstream_of_or_within lung vasculature development PubMed 
    acts_upstream_of_or_within maternal process involved in female pregnancy PubMed 
    acts_upstream_of meiotic nuclear division PubMed 
    acts_upstream_of_or_within muscle organ morphogenesis PubMed 
    acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade PubMed 
    involved_in negative regulation of angiogenesis  
    acts_upstream_of_or_within negative regulation of cell population proliferation PubMed 
    acts_upstream_of_or_within negative regulation of hormone secretion  
    acts_upstream_of_or_within negative regulation of meiotic nuclear division PubMed 
    acts_upstream_of_or_within neuron development PubMed 
    acts_upstream_of_or_within positive regulation of MAPK cascade  
    acts_upstream_of_or_within positive regulation of astrocyte differentiation PubMed 
    involved_in positive regulation of cell adhesion mediated by integrin  
    involved_in positive regulation of cell adhesion mediated by integrin  
    involved_in positive regulation of cell population proliferation  
    acts_upstream_of_or_within positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of corticotropin secretion  
    acts_upstream_of_or_within positive regulation of fibroblast proliferation PubMed 
    acts_upstream_of_or_within positive regulation of gene expression PubMed 
    acts_upstream_of_or_within positive regulation of macrophage differentiation  
    involved_in positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  
    involved_in positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  
    involved_in positive regulation of neuron projection development  
    acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation  
    involved_in positive regulation of peptidyl-serine phosphorylation of STAT protein  
    acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation  
    involved_in positive regulation of receptor signaling pathway via STAT  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of tyrosine phosphorylation of STAT protein  
    acts_upstream_of_or_within regulation of RNA polymerase II regulatory region sequence-specific DNA binding PubMed 
    involved_in regulation of cell differentiation  
    acts_upstream_of_or_within regulation of cell differentiation PubMed 
    involved_in regulation of metanephric nephron tubule epithelial cell differentiation  
    involved_in regulation of metanephric nephron tubule epithelial cell differentiation  
    acts_upstream_of_or_within response to hypoxia PubMed 
    involved_in retina development in camera-type eye  
    acts_upstream_of_or_within somatic stem cell population maintenance PubMed 
    acts_upstream_of_or_within somatic stem cell population maintenance PubMed 
    acts_upstream_of_or_within spongiotrophoblast differentiation PubMed 
    acts_upstream_of_or_within stem cell differentiation PubMed 
    involved_in transdifferentiation  
    acts_upstream_of_or_within trophoblast giant cell differentiation PubMed 
    acts_upstream_of_or_within tyrosine phosphorylation of STAT protein PubMed 
    Items 1 - 25 of 67
    Component Evidence Code Pubs
    located_in cytosol  
    located_in cytosol  
    located_in extracellular space PubMed 
    is_active_in extracellular space  
    located_in extracellular space  

    General protein information

    Preferred Names
    leukemia inhibitory factor
    Names
    d factor
    differentiation-stimulating factor
    myeloid leukaemia inhibitory factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039537.3NP_001034626.1  leukemia inhibitory factor isoform b

      See identical proteins and their annotated locations for NP_001034626.1

      Status: VALIDATED

      Source sequence(s)
      AL731658
      Consensus CDS
      CCDS24384.1
      UniProtKB/TrEMBL
      F8WH42
      Related
      ENSMUSP00000036853.4, ENSMUST00000040750.4
      Conserved Domains (1) summary
      smart00080
      Location:1147
      LIF_OSM; leukemia inhibitory factor
    2. NM_001412335.1NP_001399264.1  leukemia inhibitory factor isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AL731658
      UniProtKB/Swiss-Prot
      P09056
      UniProtKB/TrEMBL
      Q3U1H5
    3. NM_008501.3NP_032527.1  leukemia inhibitory factor isoform a precursor

      See identical proteins and their annotated locations for NP_032527.1

      Status: VALIDATED

      Source sequence(s)
      AL731658
      Consensus CDS
      CCDS24383.1
      UniProtKB/Swiss-Prot
      P09056
      UniProtKB/TrEMBL
      Q3U1H5
      Related
      ENSMUSP00000067066.6, ENSMUST00000066283.12
      Conserved Domains (1) summary
      smart00080
      Location:35192
      LIF_OSM; leukemia inhibitory factor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      4207587..4222514
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514542.5XP_006514605.1  leukemia inhibitory factor isoform X1

      See identical proteins and their annotated locations for XP_006514605.1

      UniProtKB/Swiss-Prot
      P09056
      UniProtKB/TrEMBL
      Q3U1H5
      Conserved Domains (1) summary
      smart00080
      Location:35192
      LIF_OSM; leukemia inhibitory factor
    2. XM_006514543.5XP_006514606.1  leukemia inhibitory factor isoform X1

      See identical proteins and their annotated locations for XP_006514606.1

      UniProtKB/Swiss-Prot
      P09056
      UniProtKB/TrEMBL
      Q3U1H5
      Conserved Domains (1) summary
      smart00080
      Location:35192
      LIF_OSM; leukemia inhibitory factor
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