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    Traf3ip1 TRAF3 interacting protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 74019, updated on 9-Dec-2024

    Summary

    Official Symbol
    Traf3ip1provided by MGI
    Official Full Name
    TRAF3 interacting protein 1provided by MGI
    Primary source
    MGI:MGI:1921269
    See related
    Ensembl:ENSMUSG00000034292 AllianceGenome:MGI:1921269
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MIP-T3; 3930402D05Rik
    Summary
    Predicted to enable microtubule binding activity and signaling receptor binding activity. Involved in morphogenesis of a polarized epithelium; negative regulation of defense response to virus; and regulation of microtubule cytoskeleton organization. Acts upstream of or within several processes, including embryonic organ development; negative regulation of interferon-beta production; and post-anal tail morphogenesis. Located in axoneme; centrosome; and ciliary basal body. Part of intraciliary transport particle B. Is expressed in genitourinary system and nose. Human ortholog(s) of this gene implicated in Senior-Loken syndrome. Orthologous to human TRAF3IP1 (TRAF3 interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 7.5), CNS E11.5 (RPKM 5.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Traf3ip1 in Genome Data Viewer
    Location:
    1 D; 1 46.16 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (91422311..91457029)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (91494590..91529307)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 28382 Neighboring gene nucleolar complex associated 3 homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_01698 Neighboring gene STARR-positive B cell enhancer ABC_E1555 Neighboring gene ankyrin repeat and SOCS box-containing 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:93497438-93497621 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:93498155-93498356 Neighboring gene predicted gene 28380

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC143957

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule binding  
    enables protein binding PubMed 
    enables signaling receptor binding  
    enables tubulin binding  
    Items 1 - 25 of 31
    Process Evidence Code Pubs
    involved_in cilium assembly  
    acts_upstream_of_or_within cilium assembly PubMed 
    involved_in cilium assembly PubMed 
    acts_upstream_of defense response to virus PubMed 
    acts_upstream_of_or_within embryonic camera-type eye development PubMed 
    acts_upstream_of_or_within embryonic digit morphogenesis PubMed 
    acts_upstream_of_or_within embryonic heart tube development PubMed 
    acts_upstream_of interferon-beta production PubMed 
    involved_in intraciliary anterograde transport PubMed 
    involved_in intraciliary transport  
    acts_upstream_of_or_within intraciliary transport PubMed 
    involved_in kidney development  
    involved_in kidney development  
    involved_in morphogenesis of a polarized epithelium PubMed 
    involved_in morphogenesis of a polarized epithelium  
    acts_upstream_of_or_within negative regulation of defense response to virus PubMed 
    involved_in negative regulation of defense response to virus PubMed 
    involved_in negative regulation of defense response to virus  
    acts_upstream_of_or_within negative regulation of interferon-beta production PubMed 
    involved_in negative regulation of protein phosphorylation  
    involved_in negative regulation of protein-containing complex assembly  
    acts_upstream_of_or_within negative regulation of smoothened signaling pathway PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of type I interferon production  
    acts_upstream_of_or_within negative regulation of tyrosine phosphorylation of STAT protein  
    acts_upstream_of_or_within neural tube patterning PubMed 
    acts_upstream_of_or_within post-anal tail morphogenesis PubMed 
    acts_upstream_of_or_within regulation of DNA binding  
    involved_in regulation of microtubule cytoskeleton organization  
    involved_in regulation of microtubule cytoskeleton organization PubMed 
    involved_in regulation of microtubule cytoskeleton organization  
    Items 1 - 25 of 31
    Component Evidence Code Pubs
    is_active_in axoneme  
    located_in axoneme PubMed 
    located_in centrosome PubMed 
    is_active_in ciliary basal body  
    located_in ciliary basal body PubMed 
    located_in ciliary base  
    located_in ciliary base  
    located_in ciliary tip  
    located_in ciliary tip  
    located_in ciliary transition zone  
    located_in ciliary transition zone  
    located_in cilium PubMed 
    located_in cilium PubMed 
    located_in cilium  
    located_in cytosol  
    part_of intraciliary transport particle B  
    part_of intraciliary transport particle B PubMed 
    part_of intraciliary transport particle B  
    located_in microtubule cytoskeleton  

    General protein information

    Preferred Names
    TRAF3-interacting protein 1
    Names
    TNF receptor-associated factor 3 interacting protein 1
    intraflagellar transport protein 54 homolog
    microtubule-interacting protein associated with TRAF3
    microtubule-interacting protein that associates with TRAF3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028718.2NP_082994.1  TRAF3-interacting protein 1

      See identical proteins and their annotated locations for NP_082994.1

      Status: VALIDATED

      Source sequence(s)
      AY613437, BC051115, BY739359, CK794620
      Consensus CDS
      CCDS35664.1
      UniProtKB/Swiss-Prot
      Q149C2, Q538H5, Q80VQ3, Q9CS98
      Related
      ENSMUSP00000042391.8, ENSMUST00000047242.9
      Conserved Domains (1) summary
      pfam10243
      Location:49619
      MIP-T3; Microtubule-binding protein MIP-T3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      91422311..91457029
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153864.1XP_036009757.1  TRAF3-interacting protein 1 isoform X1

      Conserved Domains (3) summary
      PTZ00121
      Location:118392
      PTZ00121; MAEBL; Provisional
      pfam10243
      Location:5117
      MIP-T3; Microtubule-binding protein MIP-T3
      pfam17749
      Location:552706
      MIP-T3_C; Microtubule-binding protein MIP-T3 C-terminal region
    2. XM_036153867.1XP_036009760.1  TRAF3-interacting protein 1 isoform X2

      Conserved Domains (3) summary
      PTZ00121
      Location:100362
      PTZ00121; MAEBL; Provisional
      pfam10243
      Location:5117
      MIP-T3; Microtubule-binding protein MIP-T3
      pfam17749
      Location:528682
      MIP-T3_C; Microtubule-binding protein MIP-T3 C-terminal region
    3. XM_006529896.2XP_006529959.1  TRAF3-interacting protein 1 isoform X3

      Conserved Domains (3) summary
      PTZ00121
      Location:100672
      PTZ00121; MAEBL; Provisional
      pfam10243
      Location:5117
      MIP-T3; Microtubule-binding protein MIP-T3
      pfam17749
      Location:518672
      MIP-T3_C; Microtubule-binding protein MIP-T3 C-terminal region
    4. XM_006529898.2XP_006529961.1  TRAF3-interacting protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A087WQD8
      Related
      ENSMUSP00000140151.2, ENSMUST00000189341.7
      Conserved Domains (3) summary
      PTZ00121
      Location:100648
      PTZ00121; MAEBL; Provisional
      pfam10243
      Location:5117
      MIP-T3; Microtubule-binding protein MIP-T3
      pfam17749
      Location:494648
      MIP-T3_C; Microtubule-binding protein MIP-T3 C-terminal region

    RNA

    1. XR_004934797.1 RNA Sequence

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