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    MZT2A mitotic spindle organizing protein 2A [ Homo sapiens (human) ]

    Gene ID: 653784, updated on 27-Nov-2024

    Summary

    Official Symbol
    MZT2Aprovided by HGNC
    Official Full Name
    mitotic spindle organizing protein 2Aprovided by HGNC
    Primary source
    HGNC:HGNC:33187
    See related
    Ensembl:ENSG00000173272 MIM:613449; AllianceGenome:HGNC:33187
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAM128A; MOZART2A
    Summary
    Located in centrosome; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in prostate (RPKM 4.8), colon (RPKM 4.6) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MZT2A in Genome Data Viewer
    Location:
    2q21.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (131469728..131493754, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (131904493..131928522, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (132241533..132249970, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene NOC2 like nucleolar associated transcriptional repressor pseudogene 2 Neighboring gene ras homolog family member Q pseudogene 2 Neighboring gene tubulin alpha 3d Neighboring gene hESC enhancers GRCh37_chr2:132249301-132250094 and GRCh37_chr2:132250095-132250888 Neighboring gene microRNA 4784 Neighboring gene sphingomyelin phosphodiesterase 4B, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:132279157-132279881 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11967 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16534 Neighboring gene coiled-coil domain containing 74A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16535 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:132293270-132293826 Neighboring gene mediator complex subunit 15 pseudogene 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of gamma-tubulin ring complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in spindle ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    mitotic-spindle organizing protein 2A
    Names
    family with sequence similarity 128, member A
    mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085365.2NP_001078834.1  mitotic-spindle organizing protein 2A

      See identical proteins and their annotated locations for NP_001078834.1

      Status: VALIDATED

      Source sequence(s)
      BM554057, BU682101
      Consensus CDS
      CCDS42758.1
      UniProtKB/Swiss-Prot
      Q3SWV8, Q6P582, Q8WVB2
      UniProtKB/TrEMBL
      A0A494C0V9
      Related
      ENSP00000311500.6, ENST00000309451.7
      Conserved Domains (1) summary
      pfam12926
      Location:996
      MOZART2; Mitotic-spindle organizing gamma-tubulin ring associated

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      131469728..131493754 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047445568.1XP_047301524.1  mitotic-spindle organizing protein 2A isoform X1

    2. XM_005263742.4XP_005263799.2  mitotic-spindle organizing protein 2A isoform X2

      Related
      ENSP00000403353.1, ENST00000427024.5
    3. XM_047445570.1XP_047301526.1  mitotic-spindle organizing protein 2A isoform X4

    4. XM_047445569.1XP_047301525.1  mitotic-spindle organizing protein 2A isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      131904493..131928522 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047443952.1XP_047299908.1  mitotic-spindle organizing protein 2A isoform X1

    2. XM_054343496.1XP_054199471.1  mitotic-spindle organizing protein 2A isoform X6

    3. XM_054343495.1XP_054199470.1  mitotic-spindle organizing protein 2A isoform X5

    4. XM_054343498.1XP_054199473.1  mitotic-spindle organizing protein 2A isoform X8

    5. XM_054343497.1XP_054199472.1  mitotic-spindle organizing protein 2A isoform X7