Apobec2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Apobec2provided by MGI
Official Full Name: apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2provided by MGI
Primary source: MGI:MGI:1343178
See related: Ensembl:ENSMUSG00000040694 AllianceGenome:MGI:1343178
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Arp1
Summary: Enables cytidine deaminase activity. Acts upstream of or within cytidine to uridine editing and mRNA modification. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including head mesenchyme; lower urogenital tract; reproductive system; urethra epithelium; and vertebral axis musculature. Orthologous to human APOBEC2 (apolipoprotein B mRNA editing enzyme catalytic subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in heart adult (RPKM 62.8), mammary gland adult (RPKM 42.7) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 C; 17 24.02 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (48726259..48739756, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (48419231..48432728, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

APOBEC2 safeguards skeletal muscle cell fate through binding chromatin and regulating transcription of non-muscle genes during myoblast differentiation.
Title: APOBEC2 safeguards skeletal muscle cell fate through binding chromatin and regulating transcription of non-muscle genes during myoblast differentiation.
PAX7 Balances the Cell Cycle Progression via Regulating Expression of Dnmt3b and Apobec2 in Differentiating PSCs.
Title: PAX7 Balances the Cell Cycle Progression via Regulating Expression of Dnmt3b and Apobec2 in Differentiating PSCs.
Apobec2 deficiency causes mitochondrial defects that increase muscle mitophagy, leading to myopathy and atrophy. Findings demonstrate that Apobec2 is required for mitochondrial homeostasis to maintain normal skeletal muscle function.
Title: Apobec2 deficiency causes mitochondrial defects and mitophagy in skeletal muscle.
gene-specific shRNA enhance DNA vaccine immunogenicity
Title: Modulating APOBEC expression enhances DNA vaccine immunogenicity.
Hepatocellular carcinoma developed in 2 of 20 APOBEC2 transgenic mice at 72 weeks of age.
Title: Excessive activity of apolipoprotein B mRNA editing enzyme catalytic polypeptide 2 (APOBEC2) contributes to liver and lung tumorigenesis.
Data show that APOBEC2 is preferentially associated with slow-twitch muscle, with its abundance being considerably greater in soleus compared with gastrocnemius muscle and, within soleus muscle, in slow as opposed to fast muscle fibers.
Title: Deficiency in APOBEC2 leads to a shift in muscle fiber type, diminished body mass, and myopathy.
both APOBEC2 (despite being an ancestral member of the family with no obvious redundancy in muscle) and APOBEC3 (despite its proposed role in restricting endogenous retrotransposition) are inessential for mouse development, survival, or fertility
Title: Mice deficient in APOBEC2 and APOBEC3.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Apobec2 (e-PCR), detects polymorphism
- UniSTS:141111

RH128626 (e-PCR)
- UniSTS:211934

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytidine deaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytidine deaminase activity	IDA Inferred from Direct Assay more info	PubMed
enables cytidine deaminase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cytidine to uridine editing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cytidine to uridine editing	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cytidine to uridine editing	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within mRNA modification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression via chromosomal CpG island demethylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression via chromosomal CpG island demethylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: C->U-editing enzyme APOBEC-2

Names: apolipoprotein B editing complex 2; mRNA(cytosine(6666)) deaminase 2; probable C->U-editing enzyme APOBEC-2

NP_033824.1

EC 3.5.4.36

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009694.3 → NP_033824.1 C->U-editing enzyme APOBEC-2

See identical proteins and their annotated locations for NP_033824.1

Status: VALIDATED

Source sequence(s)

AC165291, AC166164

Consensus CDS

CCDS28868.1

UniProtKB/Swiss-Prot

Q9WV35

Related

ENSMUSP00000047402.4, ENSMUST00000046549.5

Conserved Domains (3) summary

cd01283
Location:61 → 151

cytidine_deaminase; Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on ...

pfam05240
Location:160 → 208

APOBEC_C; APOBEC-like C-terminal domain

pfam08210
Location:52 → 221

APOBEC_N; APOBEC-like N-terminal domain