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    Neurl4 neuralized E3 ubiquitin protein ligase 4 [ Mus musculus (house mouse) ]

    Gene ID: 216860, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Neurl4provided by MGI
    Official Full Name
    neuralized E3 ubiquitin protein ligase 4provided by MGI
    Primary source
    MGI:MGI:1921092
    See related
    Ensembl:ENSMUSG00000047284 AllianceGenome:MGI:1921092
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within mitochondrial DNA repair and spermatogenesis. Predicted to be located in centriole and mitochondrion. Orthologous to human NEURL4 (neuralized E3 ubiquitin protein ligase 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 24.9), CNS E14 (RPKM 22.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Neurl4 in Genome Data Viewer
    Location:
    11 B3; 11 42.92 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69792545..69804648)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69901727..69913824)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene microRNA 6924 Neighboring gene ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:69708255-69708446 Neighboring gene RIKEN cDNA 2810408A11 gene Neighboring gene STARR-positive B cell enhancer ABC_E7007 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:69715057-69715244 Neighboring gene STARR-positive B cell enhancer ABC_E5243 Neighboring gene STARR-positive B cell enhancer ABC_E8420 Neighboring gene G protein pathway suppressor 2 Neighboring gene STARR-positive B cell enhancer ABC_E1831 Neighboring gene eukaryotic translation initiation factor 5A Neighboring gene Y box protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Neuralized-like protein 4 (NEURL4) mediates ADP-ribosylation of mitochondrial proteins. Cardamone MD, et al. J Cell Biol, 2022 Mar 7. PMID 35157000, Free PMC Article
    2. RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain. Valnegri P, et al. Nat Commun, 2017 Nov 2. PMID 29097665, Free PMC Article
    3. Autism-linked UBE3A gain-of-function mutation causes interneuron and behavioral phenotypes when inherited maternally or paternally in mice. Xing L, et al. Cell Rep, 2023 Jul 25. PMID 37389991, Free PMC Article
    4. The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway. Imai Y, et al. PLoS Genet, 2015 Sep. PMID 26355680, Free PMC Article
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • KIAA1787, MGC189889, 0610025P10Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within mitochondrial DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    neuralized-like protein 4
    Names
    neuralized homolog 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013414.4 → NP_001013432.1  neuralized-like protein 4 isoform 1

      See identical proteins and their annotated locations for NP_001013432.1

      Status: VALIDATED

      Source sequence(s)
      AL596185
      Consensus CDS
      CCDS24921.1
      UniProtKB/Swiss-Prot
      Q3U090, Q5NCX4, Q5NCX5, Q69ZA2, Q8R1V5
      UniProtKB/TrEMBL
      B2RY59
      Related
      ENSMUSP00000053235.5, ENSMUST00000061837.11
      Conserved Domains (2) summary
      smart00588
      Location:318 → 439
      NEUZ; domain in neuralized proteins
      cd12887
      Location:525 → 686
      SPRY_NHR_like; SPRY domain in neuralized homology repeat

    2. NM_001291118.2 → NP_001278047.1  neuralized-like protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL596185
      Consensus CDS
      CCDS70220.1
      UniProtKB/TrEMBL
      B2RY59, H3BJZ3
      Related
      ENSMUSP00000135185.2, ENSMUST00000177476.8
      Conserved Domains (2) summary
      smart00588
      Location:318 → 439
      NEUZ; domain in neuralized proteins
      cd12887
      Location:720 → 882
      SPRY_NHR_like; SPRY domain in neuralized homology repeat

    3. NM_001291119.2 → NP_001278048.1  neuralized-like protein 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL596185
      Consensus CDS
      CCDS70221.1
      UniProtKB/TrEMBL
      B7ZWP0, H3BK72
      Related
      ENSMUSP00000135277.2, ENSMUST00000177138.8
      Conserved Domains (2) summary
      smart00588
      Location:296 → 417
      NEUZ; domain in neuralized proteins
      cd12887
      Location:698 → 860
      SPRY_NHR_like; SPRY domain in neuralized homology repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      69792545..69804648
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532909.3 → XP_006532972.1  neuralized-like protein 4 isoform X2

      See identical proteins and their annotated locations for XP_006532972.1

      UniProtKB/TrEMBL
      B2RY59
      Conserved Domains (1) summary
      cd12887
      Location:525 → 686
      SPRY_NHR_like; SPRY domain in neuralized homology repeat

    2. XM_017314458.2 → XP_017169947.1  neuralized-like protein 4 isoform X1

      UniProtKB/TrEMBL
      B7ZWP0
      Related
      ENSMUSP00000104257.4, ENSMUST00000108617.10
      Conserved Domains (1) summary
      cd12887
      Location:503 → 664
      SPRY_NHR_like; SPRY domain in neuralized homology repeat

    3. XM_036156572.1 → XP_036012465.1  neuralized-like protein 4 isoform X3

      UniProtKB/TrEMBL
      B2RY59
      Conserved Domains (1) summary
      cd12887
      Location:279 → 440
      SPRY_NHR_like; SPRY domain in neuralized homology repeat

    4. XM_006532911.1 → XP_006532974.1  neuralized-like protein 4 isoform X4

      See identical proteins and their annotated locations for XP_006532974.1

      Conserved Domains (1) summary
      cd12887
      Location:16 → 180
      SPRY_NHR_like; SPRY domain in neuralized homology repeat

    RNA

    1. XR_001779952.3 RNA Sequence

    2. XR_001779951.3 RNA Sequence

    3. XR_388403.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5NCX5.1 GenPept UniProtKB/Swiss-Prot:Q5NCX5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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