Ap1m1 adaptor-related protein complex AP-1, mu subunit 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ap1m1provided by MGI
Official Full Name: adaptor-related protein complex AP-1, mu subunit 1provided by MGI
Primary source: MGI:MGI:102776
See related: Ensembl:ENSMUSG00000003033 AllianceGenome:MGI:102776
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AP47; mu1A; Cltnm; Adtm1A
Summary: This gene encodes the mu-1 subunit of the scaffolding adapter protein complex AP-1 and is a member of the mu adaptin family. The AP-1 complex, which consists of 4 subunits (mu-adaptin, beta-prime adaptin, gamma-adaptin, and the small chain adaptin), is one of the predominant coat proteins of membrane vesicles involved in eukaryotic post-Golgi trafficking. The AP-1 complex is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. AP-1 complex subunit mu-1 and other mu-adaptins select cargo proteins bearing sequence-specific sorting motifs. [provided by RefSeq, Jul 2016]
Expression: Ubiquitous expression in testis adult (RPKM 143.4), whole brain E14.5 (RPKM 62.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B3.3; 8 34.92 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (72993857..73011230)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (72240013..72257386)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

L-selectin is transported constitutively by the AP-1 complex, leading to the formation of a trans-Golgi network reserve pool; phosphorylation of the L-selectin tail blocks AP-1-dependent retrograde transport of L-selectin
Title: The cytoplasmic tail of L-selectin interacts with the adaptor-protein complex AP-1 subunit μ1A via a novel basic binding motif.
In mu1A-adaptin-deficient fibroblasts, MPR300-mediated endocytosis is markedly enhanced by a mechanism not associated with increased steady-state concentration of receptors at the plasma membrane, but with an increased internalization rate of MPR300.
Title: Mu 1A deficiency induces a profound increase in MPR300/IGF-II receptor internalization rate.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:225314 (e-PCR)
- UniSTS:225314

RH124788 (e-PCR)
- UniSTS:161610

BB433211 (e-PCR)
- UniSTS:208299

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables clathrin adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in endosome to melanosome transport	IEA Inferred from Electronic Annotation more info
involved_in endosome to melanosome transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular protein transport	TAS Traceable Author Statement more info	PubMed
involved_in melanosome assembly	NAS Non-traceable Author Statement more info	PubMed
involved_in melanosome organization	ISO Inferred from Sequence Orthology more info
involved_in platelet dense granule organization	NAS Non-traceable Author Statement more info	PubMed
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within vesicle-mediated transport	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of AP-1 adaptor complex	NAS Non-traceable Author Statement more info	PubMed
is_active_in clathrin-coated vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in early endosome	NAS Non-traceable Author Statement more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network	TAS Traceable Author Statement more info	PubMed
located_in trans-Golgi network membrane	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: AP-1 complex subunit mu-1

Names: AP-mu chain family member mu1A; adapter-related protein complex 1 subunit mu-1; adaptor protein complex AP-1 mu-1 subunit; adaptor-related protein complex 1 mu-1 subunit; clathrin assembly protein complex 1 medium chain 1; clathrin assembly protein complex 1 mu-1 medium chain 1; clathrin coat assembly protein AP47; clathrin coat-associated protein AP47; golgi adaptor HA1/AP1 adaptin mu-1 subunit; mu-adaptin 1; mu1A-adaptin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007456.5 → NP_031482.1 AP-1 complex subunit mu-1

See identical proteins and their annotated locations for NP_031482.1

Status: REVIEWED

Source sequence(s)

AC158898, AK148173, CJ075420, CX240144

Consensus CDS

CCDS22411.1

UniProtKB/Swiss-Prot

P35585

UniProtKB/TrEMBL

Q3UG16

Related

ENSMUSP00000003117.9, ENSMUST00000003117.15

Conserved Domains (2) summary

cd09258
Location:153 → 422

AP-1_Mu1A_Cterm; C-terminal domain of medium Mu1A subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-1

cd14835
Location:4 → 142

AP1_Mu_N; AP-1 complex subunit mu N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

72993857..73011230

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006509538.4 → XP_006509601.1 AP-1 complex subunit mu-1 isoform X1

Conserved Domains (2) summary

cd09258
Location:127 → 396

AP-1_Mu1A_Cterm; C-terminal domain of medium Mu1A subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-1

cd14835
Location:1 → 116

AP1_Mu_N; AP-1 complex subunit mu N-terminal domain
XM_030243252.2 → XP_030099112.1 AP-1 complex subunit mu-1 isoform X1

Conserved Domains (2) summary

cd09258
Location:127 → 396

AP-1_Mu1A_Cterm; C-terminal domain of medium Mu1A subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-1

cd14835
Location:1 → 116

AP1_Mu_N; AP-1 complex subunit mu N-terminal domain