Itgal integrin alpha L [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Itgalprovided by MGI
Official Full Name: integrin alpha Lprovided by MGI
Primary source: MGI:MGI:96606
See related: Ensembl:ENSMUSG00000030830 AllianceGenome:MGI:96606
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cd11a; LFA-1; Ly-15; Ly-21; (p180); LFA-1A
Summary: Predicted to enable ICAM-3 receptor activity and integrin binding activity. Involved in cell-cell adhesion. Acts upstream of or within several processes, including activated T cell proliferation; positive regulation of T cell proliferation; and positive regulation of calcium-mediated signaling. Located in cell-cell junction; external side of plasma membrane; and immunological synapse. Is expressed in heart; hemolymphoid system; and vault of skull. Orthologous to human ITGAL (integrin subunit alpha L). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in thymus adult (RPKM 94.8), spleen adult (RPKM 38.1) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F3; 7 69.44 cM

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (126895404..126934309)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (127296139..127335137)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD11c participates in triggering acute graft-versus-host disease during bone marrow transplantation.
Title: CD11c participates in triggering acute graft-versus-host disease during bone marrow transplantation.
Distinct Roles of LFA-1 and ICAM-1 on ILC2s Control Lung Infiltration, Effector Functions, and Development of Airway Hyperreactivity.
Title: Distinct Roles of LFA-1 and ICAM-1 on ILC2s Control Lung Infiltration, Effector Functions, and Development of Airway Hyperreactivity.
LFA-1 Controls Th1 and Th17 Motility Behavior in the Inflamed Central Nervous System.
Title: LFA-1 Controls Th1 and Th17 Motility Behavior in the Inflamed Central Nervous System.
ICAM-1-LFA-1 Dependent CD8+ T-Lymphocyte Aggregation in Tumor Tissue Prevents Recirculation to Draining Lymph Nodes.
Title: ICAM-1-LFA-1 Dependent CD8+ T-Lymphocyte Aggregation in Tumor Tissue Prevents Recirculation to Draining Lymph Nodes.
The data point to two related but distinct mechanisms by which PTPN22 regulates LFA-1 dependent signals to enhance Th1 development, highlighting how perturbations to PTPN22 function over time to regulate the balance of the immune response.
Title: Protein tyrosine phosphatase PTPN22 regulates LFA-1 dependent Th1 responses.
An intracellular pool of LFA-1 in naive CD8(+) T cells plays a key role in T cell activation and differentiation.
Title: A novel intracellular pool of LFA-1 is critical for asymmetric CD8(+) T cell activation and differentiation.
Extracellular ISG15 signals cytokine secretion through the LFA-1 integrin receptor (CD11a/CD18) in natural killer cells.
Title: Extracellular ISG15 Signals Cytokine Secretion through the LFA-1 Integrin Receptor.
Inhibition of LFA-1 early after sepsis prevents the loss of unactivated memory-phenotype CD8 T cells but does not affect activation. LFA-1 blockade improves 7-day survival in sepsis in a lymphocyte-dependent manner.
Title: Attrition of memory CD8 T cells during sepsis requires LFA-1.
Data show that the marker antigen CD11A- fraction of hematopoietic stem cells (HSCs) contains all functional HSC activity, with the CD11A+ fraction composed of more differentiated cells that lack long-term self-renewal activity.
Title: Upregulation of CD11A on hematopoietic stem cells denotes the loss of long-term reconstitution potential.
competitive bone marrow-reconstitution assays revealed an essential role for CD11a in the generation of thymocytes and mature T and B cells
Title: CD11a is essential for normal development of hematopoietic intermediates.

Submit: New GeneRIF Correction See all GeneRIFs (57)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Spontaneous (1) 1 citation
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Itgal (e-PCR), detects polymorphism
- UniSTS:143625

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ICAM-3 receptor activity	ISO Inferred from Sequence Orthology more info
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within activated T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of calcium-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within leukocyte cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within leukocyte cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leukocyte cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in memory T cell extravasation	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of calcium-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor clustering	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in immunological synapse	IDA Inferred from Direct Assay more info	PubMed
part_of integrin alphaL-beta2 complex	ISO Inferred from Sequence Orthology more info
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: integrin alpha-L

Names: CD11 antigen-like family member A; alpha L integrin; leukocyte adhesion glycoprotein LFA-1 alpha chain; leukocyte function-associated molecule 1 alpha chain; lymphocyte antigen 15; lymphocyte function associated antigen 1, alpha polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001253872.1 → NP_001240801.1 integrin alpha-L isoform 1 precursor

See identical proteins and their annotated locations for NP_001240801.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC133494

Consensus CDS

CCDS57589.1

UniProtKB/Swiss-Prot

E9Q5M7, E9QNL8, P24063, Q3U159

UniProtKB/TrEMBL

Q9WTV4

Related

ENSMUSP00000101913.3, ENSMUST00000106306.9

Conserved Domains (2) summary

smart00191
Location:515 → 567

Int_alpha; Integrin alpha (beta-propellor repeats)

cl00057
Location:152 → 321

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
NM_001253873.1 → NP_001240802.1 integrin alpha-L isoform 3 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.

Source sequence(s)

AC133494, AK171389

Consensus CDS

CCDS57588.1

UniProtKB/TrEMBL

Q9WTV4

Related

ENSMUSP00000113946.2, ENSMUST00000117762.8

Conserved Domains (3) summary

smart00191
Location:515 → 567

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:610 → 997

Integrin_alpha2; Integrin alpha

cl00057
Location:152 → 321

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
NM_001253874.1 → NP_001240803.1 integrin alpha-L isoform 4 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.

Source sequence(s)

AC133494

UniProtKB/TrEMBL

B7ZN91

Conserved Domains (3) summary

smart00191
Location:515 → 567

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:610 → 998

Integrin_alpha2; Integrin alpha

cl00057
Location:152 → 321

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
NM_008400.3 → NP_032426.2 integrin alpha-L isoform 2 precursor

See identical proteins and their annotated locations for NP_032426.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an two alternate in-frame splice sites in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AC133494, BC145096

UniProtKB/TrEMBL

B7ZN92, Q9WTV4

Conserved Domains (3) summary

smart00191
Location:515 → 567

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:610 → 997

Integrin_alpha2; Integrin alpha

cl00057
Location:152 → 321

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

126895404..126934309

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006507393.5 → XP_006507456.1 integrin alpha-L isoform X1

Conserved Domains (3) summary

smart00191
Location:515 → 567

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:610 → 740

Integrin_alpha2; Integrin alpha

cl00057
Location:152 → 321

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...