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    Tslp thymic stromal lymphopoietin [ Mus musculus (house mouse) ]

    Gene ID: 53603, updated on 27-Nov-2024

    Summary

    Official Symbol
    Tslpprovided by MGI
    Official Full Name
    thymic stromal lymphopoietinprovided by MGI
    Primary source
    MGI:MGI:1855696
    See related
    Ensembl:ENSMUSG00000024379 AllianceGenome:MGI:1855696
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables cytokine activity. Predicted to be involved in several processes, including defense response to other organism; positive regulation of cytokine production; and positive regulation of signal transduction. Is active in extracellular space. Is expressed in ileum; male reproductive gland or organ; and skin. Used to study atopic dermatitis; autoimmune hemolytic anemia; cryoglobulinemia; and membranoproliferative glomerulonephritis. Orthologous to human TSLP (thymic stromal lymphopoietin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in bladder adult (RPKM 2.0), limb E14.5 (RPKM 0.6) and 12 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tslp in Genome Data Viewer
    Location:
    18 B1; 18 18.12 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (32948436..32952852)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (32815383..32819799)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25826 Neighboring gene STARR-seq mESC enhancer starr_44158 Neighboring gene RIKEN cDNA 4930455D15 gene Neighboring gene STARR-seq mESC enhancer starr_44159 Neighboring gene predicted gene, 57654 Neighboring gene STARR-seq mESC enhancer starr_44160 Neighboring gene predicted gene, 26378 Neighboring gene WD repeat domain 36

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cytokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cytokine activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables interleukin-7 receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables interleukin-7 receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to Gram-negative bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to fungus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in interleukin-7-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of chemokine (C-C motif) ligand 1 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of chemokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of chemokine production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of granulocyte colony-stimulating factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-10 production IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of interleukin-10 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-13 production IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of interleukin-13 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-5 production IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of interleukin-5 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-6 production IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mast cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of receptor signaling pathway via STAT ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    thymic stromal lymphopoietin
    Names
    thymic stroma-derived lymphopoietin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021367.2NP_067342.1  thymic stromal lymphopoietin precursor

      See identical proteins and their annotated locations for NP_067342.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the functional protein.
      Source sequence(s)
      AC140983, AK087266, CJ198416
      Consensus CDS
      CCDS29121.1
      UniProtKB/Swiss-Prot
      Q9JIE6
      Related
      ENSMUSP00000025237.4, ENSMUST00000025237.5
      Conserved Domains (1) summary
      pfam15216
      Location:20137
      TSLP; Thymic stromal lymphopoietin

    RNA

    1. NR_033206.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks three exons and contains a unique 5' end compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AK087266, CJ198416
      Related
      ENSMUST00000234876.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      32948436..32952852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)