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    Robo2 roundabout guidance receptor 2 [ Mus musculus (house mouse) ]

    Gene ID: 268902, updated on 3-Dec-2024

    Summary

    Official Symbol
    Robo2provided by MGI
    Official Full Name
    roundabout guidance receptor 2provided by MGI
    Primary source
    MGI:MGI:1890110
    See related
    Ensembl:ENSMUSG00000052516 AllianceGenome:MGI:1890110
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1568; 2600013A04Rik; 9430089E08Rik; D230004I22Rik
    Summary
    Predicted to enable axon guidance receptor activity and identical protein binding activity. Involved in several processes, including circulatory system development; neuron development; and positive regulation of Notch signaling pathway. Acts upstream of or within axon guidance and metanephros development. Located in axolemma. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including autopod; central nervous system; embryo mesenchyme; jaw; and urinary system. Human ortholog(s) of this gene implicated in vesicoureteral reflux. Orthologous to human ROBO2 (roundabout guidance receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E18 (RPKM 11.3), whole brain E14.5 (RPKM 10.4) and 12 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Robo2 in Genome Data Viewer
    Location:
    16 C3.1; 16 42.17 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (73688725..75244331, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (73891976..75447443, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41245 Neighboring gene predicted gene, 41472 Neighboring gene STARR-seq mESC enhancer starr_41247 Neighboring gene STARR-seq mESC enhancer starr_41248 Neighboring gene STARR-seq mESC enhancer starr_41249 Neighboring gene olfactory receptor 818 pseudogene Neighboring gene STARR-seq mESC enhancer starr_41252 Neighboring gene STARR-seq mESC enhancer starr_41253 Neighboring gene STARR-seq mESC enhancer starr_41254 Neighboring gene STARR-seq mESC enhancer starr_41256 Neighboring gene predicted gene, 22163 Neighboring gene STARR-seq mESC enhancer starr_41258 Neighboring gene STARR-seq mESC enhancer starr_41259 Neighboring gene ribosomal protein L5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_41260 Neighboring gene microRNA 691 Neighboring gene STARR-seq mESC enhancer starr_41261 Neighboring gene predicted gene, 26307 Neighboring gene predicted gene, 52242 Neighboring gene STARR-seq mESC enhancer starr_41262 Neighboring gene predicted gene, 57634 Neighboring gene STARR-seq mESC enhancer starr_41263 Neighboring gene STARR-seq mESC enhancer starr_41264 Neighboring gene predicted gene, 52278 Neighboring gene STARR-seq mESC enhancer starr_41265 Neighboring gene STARR-seq mESC enhancer starr_41266 Neighboring gene STARR-seq mESC enhancer starr_41267 Neighboring gene nuclear encoded tRNA isoleucine 1 (anticodon AAT) Neighboring gene RNA binding motif protein 11 Neighboring gene lipase, member I

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables axon guidance receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in aorta development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in aortic valve morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in axon midline choice point recognition IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in brain development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endocardial cushion formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in heart induction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within metanephros development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of negative chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in olfactory bulb interneuron development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in outflow tract septum morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of axonogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of axonogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in pulmonary valve morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in retinal ganglion cell axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synapse maturation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in synapse maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ureteric bud development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ureteric bud development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ventricular septum morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axolemma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic density membrane IEP
    Inferred from Expression Pattern
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358490.2NP_001345419.1  roundabout homolog 2 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC112155, AC122049, AC129186, AC134452, AC158234, AC162374
      UniProtKB/TrEMBL
      Q19AB3
      Conserved Domains (5) summary
      cd05726
      Location:347436
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:45144
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:443524
      IG_like; Immunoglobulin like
      cd00063
      Location:541634
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:152236
      Ig; Immunoglobulin domain
    2. NM_001358491.2NP_001345420.1  roundabout homolog 2 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC112155, AC115120, AC122049, AC134452, AC158234, AC162374
      UniProtKB/TrEMBL
      A0A2I3BR72
      Conserved Domains (5) summary
      cd05726
      Location:355444
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:451532
      IG_like; Immunoglobulin like
      cd00063
      Location:549642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:160244
      Ig; Immunoglobulin domain
    3. NM_001358492.2NP_001345421.1  roundabout homolog 2 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC112155, AC115120, AC122049, AC134452, AC158234, AC162374
      UniProtKB/TrEMBL
      E9Q6A0
      Conserved Domains (5) summary
      cd05726
      Location:355444
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:451532
      IG_like; Immunoglobulin like
      cd00063
      Location:549642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:160244
      Ig; Immunoglobulin domain
    4. NM_001358493.2NP_001345422.1  roundabout homolog 2 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC112155, AC115120, AC122049, AC134452, AC158234, AC162374
      UniProtKB/TrEMBL
      A0A2I3BR72, A0AAQ4VMV1
      Related
      ENSMUSP00000160011.1, ENSMUST00000249913.1
      Conserved Domains (5) summary
      cd05726
      Location:355444
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:451532
      IG_like; Immunoglobulin like
      cd00063
      Location:549642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:160244
      Ig; Immunoglobulin domain
    5. NM_001358494.2NP_001345423.1  roundabout homolog 2 isoform 6 precursor

      Status: VALIDATED

      Source sequence(s)
      AC112155, AC122049, AC134452, AC158234, AC162374
      UniProtKB/TrEMBL
      E9Q6A0
      Related
      ENSMUSP00000112285.5, ENSMUST00000116586.5
      Conserved Domains (5) summary
      cd05726
      Location:332421
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:30129
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:428509
      IG_like; Immunoglobulin like
      cd00063
      Location:526619
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:137221
      Ig; Immunoglobulin domain
    6. NM_001415036.1NP_001401965.1  roundabout homolog 2 isoform 7 precursor

      Status: VALIDATED

      Source sequence(s)
      AC112155, AC122049, AC134452, AC158234, AC162374
      UniProtKB/TrEMBL
      E9Q6A0
      Related
      ENSMUSP00000113795.2, ENSMUST00000117200.8
    7. NM_001415039.1NP_001401968.1  roundabout homolog 2 isoform 8 precursor

      Status: VALIDATED

      Source sequence(s)
      AC112155, AC122049, AC134452, AC158234, AC162374
      UniProtKB/Swiss-Prot
      Q7TPD3, Q8BJ59
      UniProtKB/TrEMBL
      A0A2I3BR72
      Related
      ENSMUSP00000154010.3, ENSMUST00000227347.3
    8. NM_175549.6NP_780758.3  roundabout homolog 2 isoform 5 precursor

      See identical proteins and their annotated locations for NP_780758.3

      Status: VALIDATED

      Source sequence(s)
      AC112155, AC122049, AC134452, AC158234, AC162374
      Consensus CDS
      CCDS49886.1
      UniProtKB/TrEMBL
      A0A2I3BR72, Q19AB2
      Related
      ENSMUSP00000112776.2, ENSMUST00000117785.9
      Conserved Domains (7) summary
      cd00096
      Location:435502
      Ig; Immunoglobulin domain
      cd05726
      Location:328417
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:30129
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:424505
      IG_like; Immunoglobulin like
      cd00063
      Location:522615
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:225310
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:137221
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      73688725..75244331 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159959.1XP_036015852.1  roundabout homolog 2 isoform X5

      UniProtKB/TrEMBL
      Q19AB3
      Conserved Domains (6) summary
      cd00063
      Location:537630
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:151154
      Ig; Ig strand A [structural motif]
      cd05726
      Location:330427
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:46144
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:434520
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:151236
      Ig; Immunoglobulin domain
    2. XM_006523038.4XP_006523101.1  roundabout homolog 2 isoform X4

      UniProtKB/TrEMBL
      Q19AB3
      Conserved Domains (5) summary
      cd05726
      Location:347436
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:45144
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:443524
      IG_like; Immunoglobulin like
      cd00063
      Location:541634
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:152236
      Ig; Immunoglobulin domain
    3. XM_030249139.1XP_030104999.1  roundabout homolog 2 isoform X4

      UniProtKB/TrEMBL
      Q19AB3
      Conserved Domains (5) summary
      cd05726
      Location:347436
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:45144
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:443524
      IG_like; Immunoglobulin like
      cd00063
      Location:541634
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:152236
      Ig; Immunoglobulin domain
    4. XM_030249140.1XP_030105000.1  roundabout homolog 2 isoform X4

      UniProtKB/TrEMBL
      Q19AB3
      Conserved Domains (5) summary
      cd05726
      Location:347436
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:45144
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:443524
      IG_like; Immunoglobulin like
      cd00063
      Location:541634
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:152236
      Ig; Immunoglobulin domain
    5. XM_006523049.5XP_006523112.1  roundabout homolog 2 isoform X24

      UniProtKB/TrEMBL
      E9Q6A0
      Conserved Domains (5) summary
      cd05726
      Location:351440
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:447528
      IG_like; Immunoglobulin like
      cd00063
      Location:545638
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:160244
      Ig; Immunoglobulin domain
    6. XM_036159962.1XP_036015855.1  roundabout homolog 2 isoform X16

      UniProtKB/TrEMBL
      A0A2I3BR72
      Conserved Domains (6) summary
      cd00063
      Location:545638
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:159162
      Ig; Ig strand A [structural motif]
      cd05726
      Location:338435
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:54152
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:442528
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:159244
      Ig; Immunoglobulin domain
    7. XM_036159961.1XP_036015854.1  roundabout homolog 2 isoform X9

      UniProtKB/TrEMBL
      A0A2I3BR72
      Conserved Domains (6) summary
      cd00063
      Location:545638
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:159162
      Ig; Ig strand A [structural motif]
      cd05726
      Location:338435
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:54152
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:442528
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:159244
      Ig; Immunoglobulin domain
    8. XM_036159965.1XP_036015858.1  roundabout homolog 2 isoform X22

      UniProtKB/TrEMBL
      E9Q6A0
      Conserved Domains (6) summary
      cd00063
      Location:545638
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:159162
      Ig; Ig strand A [structural motif]
      cd05726
      Location:338435
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:54152
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:442528
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:159244
      Ig; Immunoglobulin domain
    9. XM_036159964.1XP_036015857.1  roundabout homolog 2 isoform X21

      UniProtKB/TrEMBL
      E9Q6A0
      Conserved Domains (6) summary
      cd00063
      Location:545638
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:159162
      Ig; Ig strand A [structural motif]
      cd05726
      Location:338435
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:54152
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:442528
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:159244
      Ig; Immunoglobulin domain
    10. XM_006523042.5XP_006523105.1  roundabout homolog 2 isoform X11

      UniProtKB/TrEMBL
      A0A2I3BR72
      Conserved Domains (5) summary
      cd05726
      Location:351440
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:447528
      IG_like; Immunoglobulin like
      cd00063
      Location:545638
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:160244
      Ig; Immunoglobulin domain
    11. XM_006523037.5XP_006523100.1  roundabout homolog 2 isoform X3

      UniProtKB/TrEMBL
      A0A2I3BR72
      Conserved Domains (5) summary
      cd05726
      Location:351440
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00409
      Location:447528
      IG; Immunoglobulin
      cd00063
      Location:545638
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:160244
      Ig; Immunoglobulin domain
    12. XM_017317016.3XP_017172505.1  roundabout homolog 2 isoform X23

      UniProtKB/TrEMBL
      E9Q6A0
      Conserved Domains (5) summary
      cd05726
      Location:355444
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:451532
      IG_like; Immunoglobulin like
      cd00063
      Location:549642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:160244
      Ig; Immunoglobulin domain
    13. XM_006523046.5XP_006523109.1  roundabout homolog 2 isoform X15

      UniProtKB/TrEMBL
      A0A2I3BR72
      Conserved Domains (5) summary
      cd05726
      Location:355444
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:451532
      IG_like; Immunoglobulin like
      cd00063
      Location:549642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:160244
      Ig; Immunoglobulin domain
    14. XM_036159963.1XP_036015856.1  roundabout homolog 2 isoform X18

      UniProtKB/TrEMBL
      E9Q6A0
      Conserved Domains (6) summary
      cd00063
      Location:549642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:159162
      Ig; Ig strand A [structural motif]
      cd05726
      Location:342439
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:54152
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:446532
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:159244
      Ig; Immunoglobulin domain
    15. XM_011246131.4XP_011244433.1  roundabout homolog 2 isoform X17

      UniProtKB/TrEMBL
      E9Q6A0
      Conserved Domains (5) summary
      cd05726
      Location:355444
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00409
      Location:451532
      IG; Immunoglobulin
      cd00063
      Location:549642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:160244
      Ig; Immunoglobulin domain
    16. XM_006523040.5XP_006523103.1  roundabout homolog 2 isoform X8

      UniProtKB/TrEMBL
      A0A2I3BR72
      Conserved Domains (5) summary
      cd05726
      Location:355444
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00409
      Location:451532
      IG; Immunoglobulin
      cd00063
      Location:549642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:160244
      Ig; Immunoglobulin domain
    17. XM_006523048.5XP_006523111.1  roundabout homolog 2 isoform X20

      UniProtKB/TrEMBL
      E9Q6A0
      Conserved Domains (5) summary
      cd05726
      Location:355444
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:451532
      IG_like; Immunoglobulin like
      cd00063
      Location:549642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:160244
      Ig; Immunoglobulin domain
    18. XM_017317015.3XP_017172504.1  roundabout homolog 2 isoform X19

      UniProtKB/TrEMBL
      E9Q6A0
      Conserved Domains (5) summary
      cd05726
      Location:355444
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:451532
      IG_like; Immunoglobulin like
      cd00063
      Location:549642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:160244
      Ig; Immunoglobulin domain
    19. XM_006523041.5XP_006523104.1  roundabout homolog 2 isoform X10

      UniProtKB/TrEMBL
      A0A2I3BR72
      Conserved Domains (5) summary
      cd05726
      Location:355444
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:451532
      IG_like; Immunoglobulin like
      cd00063
      Location:549642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:160244
      Ig; Immunoglobulin domain
    20. XM_030249141.2XP_030105001.1  roundabout homolog 2 isoform X14

      UniProtKB/TrEMBL
      E9Q6A0
      Conserved Domains (5) summary
      cd05726
      Location:355444
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00409
      Location:451532
      IG; Immunoglobulin
      cd00063
      Location:549642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:160244
      Ig; Immunoglobulin domain
    21. XM_006523045.5XP_006523108.1  roundabout homolog 2 isoform X13

      UniProtKB/TrEMBL
      E9Q6A0
      Conserved Domains (5) summary
      cd05726
      Location:355444
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00409
      Location:451532
      IG; Immunoglobulin
      cd00063
      Location:549642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:160244
      Ig; Immunoglobulin domain
    22. XM_006523036.5XP_006523099.1  roundabout homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A2I3BR72
      Conserved Domains (5) summary
      cd05726
      Location:355444
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00409
      Location:451532
      IG; Immunoglobulin
      cd00063
      Location:549642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:160244
      Ig; Immunoglobulin domain
    23. XM_006523035.5XP_006523098.1  roundabout homolog 2 isoform X1

      UniProtKB/TrEMBL
      A0A2I3BR72
      Conserved Domains (5) summary
      cd05726
      Location:355444
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00409
      Location:451532
      IG; Immunoglobulin
      cd00063
      Location:549642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:160244
      Ig; Immunoglobulin domain
    24. XM_036159960.1XP_036015853.1  roundabout homolog 2 isoform X7

      UniProtKB/TrEMBL
      A0A2I3BR72
      Conserved Domains (6) summary
      cd00063
      Location:522615
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:136139
      Ig; Ig strand A [structural motif]
      cd05726
      Location:315412
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:31129
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:419505
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
      cl11960
      Location:136221
      Ig; Immunoglobulin domain
    25. XM_006523043.5XP_006523106.1  roundabout homolog 2 isoform X12

      UniProtKB/TrEMBL
      A0A2I3BR72
      Conserved Domains (5) summary
      cd05726
      Location:332421
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:30129
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:428509
      IG_like; Immunoglobulin like
      cd00063
      Location:526619
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:137221
      Ig; Immunoglobulin domain
    26. XM_006523039.5XP_006523102.1  roundabout homolog 2 isoform X6

      UniProtKB/TrEMBL
      A0A2I3BR72
      Conserved Domains (5) summary
      cd05726
      Location:332421
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:30129
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:428509
      IG_like; Immunoglobulin like
      cd00063
      Location:526619
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:137221
      Ig; Immunoglobulin domain