Slc15a1 solute carrier family 15 (oligopeptide transporter), member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc15a1provided by MGI
Official Full Name: solute carrier family 15 (oligopeptide transporter), member 1provided by MGI
Primary source: MGI:MGI:1861376
See related: Ensembl:ENSMUSG00000025557 AllianceGenome:MGI:1861376
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PECT1; PEPT1; D630032F02
Summary: Enables dipeptide transmembrane transporter activity; peptide:proton symporter activity; and proton-dependent oligopeptide secondary active transmembrane transporter activity. Involved in dipeptide import across plasma membrane. Acts upstream of or within oligopeptide transport. Located in brush border and membrane. Orthologous to human SLC15A1 (solute carrier family 15 member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in large intestine adult (RPKM 80.7), small intestine adult (RPKM 68.5) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 E5; 14 65.26 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (121697033..121742666, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (121459621..121505254, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PepT1-knockout mice harbor a protective metabolome beneficial for intestinal wound healing.
Title: PepT1-knockout mice harbor a protective metabolome beneficial for intestinal wound healing.
Impact of PepT1 deletion on microbiota composition and colitis requires multiple generations.
Title: Impact of PepT1 deletion on microbiota composition and colitis requires multiple generations.
Results suggest that PepT1 contributes to maintain balance of homeostasis and proper functions in the small intestine, and dysregulated miRNAs and proteins along the crypt-villus axis are highly related to this process.
Title: PepT1 Expression Helps Maintain Intestinal Homeostasis by Mediating the Differential Expression of miRNAs along the Crypt-Villus Axis.
Glycosylation of PEPT1 confers resistance against proteolytic cleavage by proteinase K, whereas a remarkable intrinsic stability against trypsin, even in the absence of N-linked glycans, was detected.
Title: Glycans in the intestinal peptide transporter PEPT1 contribute to function and protect from proteolysis.
We tested the hypothesis that PEPT2 genotypes affect the severity and prognosis of porphyria-associated kidney disease
Title: A Variant of Peptide Transporter 2 Predicts the Severity of Porphyria-Associated Kidney Disease.
findings suggested a major role of PEPT1 in the intestinal permeability and oral absorption of 5-aminolevulinic acid
Title: The proton-coupled oligopeptide transporter 1 plays a major role in the intestinal permeability and absorption of 5-aminolevulinic acid.
Data (including data from studies in transgenic/knockout mice) suggest human PEPT1 and mouse PepT1 exhibit different affinities for antibiotic cefadroxil; these differences may account for species differences in intestinal absorption of cefadroxil.
Title: Species differences in the pharmacokinetics of cefadroxil as determined in wildtype and humanized PepT1 mice.
Crystal structures of the extracellular domain from PepT1 and PepT2 provide novel insights into mammalian peptide transport.
Title: Crystal Structures of the Extracellular Domain from PepT1 and PepT2 Provide Novel Insights into Mammalian Peptide Transport.
miRNA-193a-3p can target colonic PepT1 and reduce intestinal inflammation.
Title: MicroRNA-193a-3p Reduces Intestinal Inflammation in Response to Microbiota via Down-regulation of Colonic PepT1.
PEPT1 expression is reduced during intestinal inflammation and PEPT1 is not required for muramyl dipeptide-induced immune response.
Title: Colonic expression of the peptide transporter PEPT1 is downregulated during intestinal inflammation and is not required for NOD2-dependent immune activation.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables channel inhibitor activity	ISO Inferred from Sequence Orthology more info
enables dipeptide transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables dipeptide transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables dipeptide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables peptide:proton symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables peptide:proton symporter activity	ISO Inferred from Sequence Orthology more info
enables proton-dependent oligopeptide secondary active transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables tripeptide transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables tripeptide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in dipeptide import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in dipeptide import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in dipeptide import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of amino acid transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within oligopeptide transport	IDA Inferred from Direct Assay more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in tripeptide transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: solute carrier family 15 member 1

Names: intestinal H(+)/peptide cotransporter; intestinal peptide transporter PEPT1; peptide transporter 1; proton-coupled dipeptide cotransporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053079.2 → NP_444309.2 solute carrier family 15 member 1

See identical proteins and their annotated locations for NP_444309.2

Status: VALIDATED

Source sequence(s)

AK136428, AV237408, BC116248

Consensus CDS

CCDS37017.1

UniProtKB/Swiss-Prot

E9QMX3, Q9JIP7

UniProtKB/TrEMBL

Q14BA3, Q3UWE2

Related

ENSMUSP00000085728.7, ENSMUST00000088386.8

Conserved Domains (2) summary

TIGR00926
Location:28 → 671

2A1704; Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors)

pfam00854
Location:81 → 469

PTR2; POT family