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    Aff4 AF4/FMR2 family, member 4 [ Mus musculus (house mouse) ]

    Gene ID: 93736, updated on 5-Dec-2024

    Summary

    Official Symbol
    Aff4provided by MGI
    Official Full Name
    AF4/FMR2 family, member 4provided by MGI
    Primary source
    MGI:MGI:2136171
    See related
    Ensembl:ENSMUSG00000049470 AllianceGenome:MGI:2136171
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Alf4; MCEF; Laf4l; AF5Q31
    Summary
    Acts upstream of or within spermatid development. Located in euchromatin and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human AFF4 (ALF transcription elongation factor 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 13.9), CNS E14 (RPKM 13.8) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Aff4 in Genome Data Viewer
    Location:
    11 B1.3; 11 31.93 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (53240807..53312657)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (53350640..53421830)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30525 Neighboring gene STARR-seq mESC enhancer starr_29480 Neighboring gene zinc finger, CCHC domain containing 10 Neighboring gene predicted gene, 32048 Neighboring gene predicted gene, 25930 Neighboring gene microRNA 6920 Neighboring gene STARR-positive B cell enhancer ABC_E76 Neighboring gene liver-expressed antimicrobial peptide 2 Neighboring gene ubiquinol-cytochrome c reductase, complex III subunit VII

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC107469

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to endoplasmic reticulum stress IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in euchromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
     
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of super elongation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of transcription elongation factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription elongation factor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    AF4/FMR2 family member 4
    Names
    ALL1 fused gene from 5q31

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363331.1NP_001350260.1  AF4/FMR2 family member 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL592489
      UniProtKB/TrEMBL
      B7ZNX0
      Conserved Domains (1) summary
      pfam05110
      Location:31127
      AF-4; AF-4 proto-oncoprotein
    2. NM_033565.2NP_291043.1  AF4/FMR2 family member 4 isoform 1

      See identical proteins and their annotated locations for NP_291043.1

      Status: VALIDATED

      Source sequence(s)
      AI536326, BC138999, CJ064959
      Consensus CDS
      CCDS24676.1
      UniProtKB/Swiss-Prot
      B2RST9, Q8C6K4, Q8C6W3, Q8CCH3, Q9ESC8
      Related
      ENSMUSP00000051479.6, ENSMUST00000060945.12
      Conserved Domains (1) summary
      pfam05110
      Location:31156
      AF-4; AF-4 proto-oncoprotein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      53240807..53312657
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246443.2XP_030102303.1  AF4/FMR2 family member 4 isoform X2

      UniProtKB/TrEMBL
      B7ZNX0
      Conserved Domains (1) summary
      pfam05110
      Location:31127
      AF-4; AF-4 proto-oncoprotein
    2. XM_011249331.3XP_011247633.1  AF4/FMR2 family member 4 isoform X1

      See identical proteins and their annotated locations for XP_011247633.1

      UniProtKB/Swiss-Prot
      B2RST9, Q8C6K4, Q8C6W3, Q8CCH3, Q9ESC8
      Conserved Domains (1) summary
      pfam05110
      Location:31156
      AF-4; AF-4 proto-oncoprotein