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    Stk17b serine/threonine kinase 17b (apoptosis-inducing) [ Mus musculus (house mouse) ]

    Gene ID: 98267, updated on 9-Dec-2024

    Summary

    Official Symbol
    Stk17bprovided by MGI
    Official Full Name
    serine/threonine kinase 17b (apoptosis-inducing)provided by MGI
    Primary source
    MGI:MGI:2138162
    See related
    Ensembl:ENSMUSG00000026094 AllianceGenome:MGI:2138162
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Drak2; 3110009A03Rik
    Summary
    Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including intracellular signal transduction; positive regulation of fibroblast apoptotic process; and protein autophosphorylation. Predicted to be located in Flemming body; actin cytoskeleton; and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including adrenal medulla; alimentary system; central nervous system; immune system; and testis. Orthologous to human STK17B (serine/threonine kinase 17b). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in spleen adult (RPKM 11.6), thymus adult (RPKM 7.9) and 26 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Stk17b in Genome Data Viewer
    Location:
    1 C1.1; 1 26.99 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (53794671..53824374, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (53755512..53785237, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53553 Neighboring gene solute carrier family 39 (zinc transporter), member 10 pseudogene Neighboring gene dynein, axonemal, heavy chain 7A Neighboring gene STARR-seq mESC enhancer starr_00916 Neighboring gene STARR-seq mESC enhancer starr_00917 Neighboring gene STARR-seq mESC enhancer starr_00918 Neighboring gene STARR-seq mESC enhancer starr_00919 Neighboring gene STARR-seq mESC enhancer starr_00920 Neighboring gene STARR-positive B cell enhancer ABC_E7724 Neighboring gene STARR-seq mESC enhancer starr_00921 Neighboring gene STARR-seq mESC enhancer starr_00924 Neighboring gene predicted gene, 32311 Neighboring gene STARR-positive B cell enhancer ABC_E627 Neighboring gene STARR-positive B cell enhancer ABC_E1544 Neighboring gene STARR-positive B cell enhancer ABC_E3276 Neighboring gene STARR-seq mESC enhancer starr_00925 Neighboring gene STARR-positive B cell enhancer ABC_E7726 Neighboring gene STARR-positive B cell enhancer ABC_E5754 Neighboring gene STARR-seq mESC enhancer starr_00926 Neighboring gene HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 Neighboring gene microRNA 7681 Neighboring gene predicted gene, 24251

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of fibroblast apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of fibroblast apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in programmed cell death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in Flemming body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Flemming body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase 17B
    Names
    DAP kinase-related apoptosis-inducing protein kinase 2
    NP_598571.2
    XP_006496422.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133810.3NP_598571.2  serine/threonine-protein kinase 17B

      See identical proteins and their annotated locations for NP_598571.2

      Status: VALIDATED

      Source sequence(s)
      AK165291, AY092028, BY034689
      Consensus CDS
      CCDS14955.1
      UniProtKB/Swiss-Prot
      Q3TNG7, Q8BG48, Q8BLV9, Q923E7
      Related
      ENSMUSP00000027263.8, ENSMUST00000027263.14
      Conserved Domains (2) summary
      smart00220
      Location:37293
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14198
      Location:24293
      STKc_DRAK2; The catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      53794671..53824374 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496359.5XP_006496422.1  serine/threonine-protein kinase 17B isoform X1

      Conserved Domains (1) summary
      cl21453
      Location:1165
      PKc_like; Protein Kinases, catalytic domain