Klrg1 killer cell lectin like receptor G1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Klrg1provided by RGD
Official Full Name: killer cell lectin like receptor G1provided by RGD
Primary source: RGD:61978
See related: EnsemblRapid:ENSRNOG00000014918 AllianceGenome:RGD:61978
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MAFA
Summary: Enables carbohydrate binding activity. Predicted to be involved in innate immune response. Predicted to be located in intracellular membrane-bounded organelle. Orthologous to human KLRG1 (killer cell lectin like receptor G1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 29.8), Lung (RPKM 24.0) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (157127571..157139372, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (155455465..155467301, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (155038936..155051449, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a key role of PPARgamma in regulating pancreatic beta-cell function by improving the stability of Pdx1 and Mafa proteins
Title: PPARγ activation attenuates glycated-serum induced pancreatic beta-cell dysfunction through enhancing Pdx1 and Mafa protein stability.
Regulates beta-cell-specific gene expression and function.
Title: MAFA controls genes implicated in insulin biosynthesis and secretion.
prolonged exposure of pancreatic islets to palmitate inhibits insulin gene transcription by impairing nuclear localization of PDX-1 and cellular expression of MafA
Title: Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans.
(MAFA), selectively regulates the Fc-epsilon-RI stimulus-response coupling network and the subsequent de novo production and secretion of inflammatory mediators.
Title: Selective inhibition of the Fc epsilon RI-induced de novo synthesis of mediators by an inhibitory receptor.
This provides additional indication of constitutive interactions between Fc epsilon RI and MAFA.
Title: Compartmentalization of the Type I Fc epsilon receptor and MAFA on mast cell membranes.
overexpression in the intestine induces intestinal epithelial cells newly to produce and release insulin
Title: MafA differentiates rat intestinal cells into insulin-producing cells.
Clustering the mast cell function-associated antigen (MAFA) leads to tyrosine phosphorylation of p62Dok and SHIP and affects RBL-2H3 cell cycle.
Title: Clustering the mast cell function-associated antigen (MAFA) leads to tyrosine phosphorylation of p62Dok and SHIP and affects RBL-2H3 cell cycle.
The functional activities of an inhibitory receptor-the mast cell function-associated antigen [review] (mast cell function-associated antigen)
Title: An unusual inhibitory receptor--the mast cell function-associated antigen (MAFA).
Interactions of the mast cell function-associated antigen with the type I Fcepsilon receptor (mast cell function-associated antigen)
Title: Interactions of the mast cell function-associated antigen with the type I Fcepsilon receptor.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carbohydrate binding	IDA Inferred from Direct Assay more info	PubMed
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in innate immune response	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: killer cell lectin-like receptor subfamily G member 1

Names: killer cell lectin-like receptor subfamily G, member 1; mast cell function-associated antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031649.3 → NP_113837.1 killer cell lectin-like receptor subfamily G member 1

See identical proteins and their annotated locations for NP_113837.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

Q64335

UniProtKB/TrEMBL

A0A8L2QB90

Related

ENSRNOP00000020094.5, ENSRNOT00000020094.7

Conserved Domains (1) summary

cd03593
Location:75 → 185

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

157127571..157139372 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006237313.5 → XP_006237375.1 killer cell lectin-like receptor subfamily G member 1 isoform X1

Conserved Domains (1) summary

cd03593
Location:40 → 150

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
XM_039108299.2 → XP_038964227.1 killer cell lectin-like receptor subfamily G member 1 isoform X2

Conserved Domains (1) summary

cd03593
Location:36 → 146

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)