Map6 microtubule-associated protein 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Map6provided by RGD
Official Full Name: microtubule-associated protein 6provided by RGD
Primary source: RGD:61804
See related: EnsemblRapid:ENSRNOG00000027204 AllianceGenome:RGD:61804
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mtap6
Summary: Enables microtubule binding activity. Involved in axonal transport of mitochondrion; positive regulation of axonogenesis; and regulation of microtubule cytoskeleton organization. Located in several cellular components, including Golgi apparatus; dendrite; and secretory vesicle. Orthologous to human MAP6 (microtubule associated protein 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 117.5), Lung (RPKM 55.0) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (162980339..163046548)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (153568020..153634415)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (164225776..164292094)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MAP6 is present at the Golgi complex and in secretory vesicles in unpolarized cells and re-distributed to newly forming axons, where it binds and stabilizes axonal microtubules. A palmitoylation cycle controls MAP6 membrane-microtubule shuttling and is required for its polarized distribution in axons.
Title: Dynamic Palmitoylation Targets MAP6 to the Axon to Promote Microtubule Stabilization during Neuronal Polarization.
Structural basis for the association of MAP6 protein with microtubules and its regulation by calmodulin.
Title: Structural basis for the association of MAP6 protein with microtubules and its regulation by calmodulin.
The neuron-specific isoform of the stable tubule-only polypeptide (STOP) interacted with the SH3A domain of ITSN1. STOP and ITSN1 were shown to form a complex in vivo.
Title: Endocytic adaptor protein intersectin 1 forms a complex with microtubule stabilizer STOP in neurons.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH12090 (e-PCR)
- UniSTS:7753

RH140743 (e-PCR)
- UniSTS:222809

RH144384 (e-PCR)
- UniSTS:233629

RH143183 (e-PCR)
- UniSTS:232430

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axonal transport of mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoskeleton-dependent intracellular transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in dendrite morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in lysosome localization	IEA Inferred from Electronic Annotation more info
involved_in lysosome localization	ISO Inferred from Sequence Orthology more info
involved_in lysosome localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
is_active_in Golgi-associated vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cis-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in secretory vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in transport vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: microtubule-associated protein 6

Names: 145-kDa STOP; MAP-6; STOP; STOP145; microtubule-associated protein 6 homolog; stable tubule-only polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398600.1 → NP_001385529.1 microtubule-associated protein 6 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

F1LQZ9

Related

ENSRNOP00000032018.7, ENSRNOT00000034389.8

Conserved Domains (2) summary

PHA03247
Location:588 → 982

PHA03247; large tegument protein UL36; Provisional

PRK07764
Location:76 → 472

PRK07764; DNA polymerase III subunits gamma and tau; Validated
NM_001398601.1 → NP_001385530.1 microtubule-associated protein 6 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A6I6G6

Conserved Domains (1) summary

PRK07764
Location:76 → 472

PRK07764; DNA polymerase III subunits gamma and tau; Validated
NM_001398602.1 → NP_001385531.1 microtubule-associated protein 6 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

Related

ENSRNOP00000110813.1, ENSRNOT00000173883.1

Conserved Domains (1) summary

PRK07764
Location:76 → 472

PRK07764; DNA polymerase III subunits gamma and tau; Validated

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

162980339..163046548

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_017204.1: Suppressed sequence

Description

NM_017204.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.