Hpn hepsin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hpnprovided by RGD
Official Full Name: hepsinprovided by RGD
Primary source: RGD:61982
See related: EnsemblRapid:ENSRNOG00000021097 AllianceGenome:RGD:61982
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in several processes, including cochlea morphogenesis; detection of mechanical stimulus involved in sensory perception of sound; and regulation of epithelial cell proliferation. Predicted to act upstream of or within cholesterol homeostasis; negative regulation of alkaline phosphatase activity; and sensory perception of sound. Predicted to be located in several cellular components, including endoplasmic reticulum membrane; neuronal cell body; and nuclear membrane. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human HPN (hepsin). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 529.1), Liver (RPKM 485.5) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (95464468..95480169, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (86337085..86352785, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (89534112..89549575, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that hepsin and PDIA3 undergo proteolysis by MMP2/9 in ovarian granulosa cells during ovulation and/or luteinization.
Title: Identification of hepsin and protein disulfide isomerase A3 as targets of gelatinolytic action in rat ovarian granulosa cells during the periovulatory period.
Ln-332 may be one mechanism by which hepsin promotes prostate tumor progression and metastasis, possibly by up-regulating prostate cancer cell motility.
Title: Laminin-332 is a substrate for hepsin, a protease associated with prostate cancer progression.

Submit: New GeneRIF Correction

General gene information

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Markers

RH131311 (e-PCR)
- UniSTS:214594

PMC15797P1 (e-PCR)
- UniSTS:271432

U85786 (e-PCR)
- UniSTS:159622

Hpn (e-PCR), detects polymorphism
- UniSTS:531087

D1Bda14 (e-PCR)
- UniSTS:239761

Hpn (e-PCR), detects polymorphism
- UniSTS:256678

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type exopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type peptidase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in basement membrane disassembly	IEA Inferred from Electronic Annotation more info
involved_in basement membrane disassembly	ISO Inferred from Sequence Orthology more info
involved_in basement membrane disassembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cochlea morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cochlea morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in detection of mechanical stimulus involved in sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in detection of mechanical stimulus involved in sensory perception of sound	ISS Inferred from Sequence or Structural Similarity more info
involved_in epithelium development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of alkaline phosphatase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of epithelial to mesenchymal transition	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of epithelial to mesenchymal transition	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial to mesenchymal transition	ISS Inferred from Sequence or Structural Similarity more info
involved_in pilomotor reflex	ISO Inferred from Sequence Orthology more info
involved_in pilomotor reflex	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation by host of viral transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation by host of viral transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell growth	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of hepatocyte proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of hepatocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hepatocyte proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of plasminogen activation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of plasminogen activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of plasminogen activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of thyroid hormone generation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of thyroid hormone generation	ISS Inferred from Sequence or Structural Similarity more info
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell shape	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to thyroid hormone	ISO Inferred from Sequence Orthology more info
involved_in response to thyroid hormone	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: serine protease hepsin

Names: hepsin (transmembrane protease, serine 1)

NP_058808.1

EC 3.4.21.106

XP_038958886.1

EC 3.4.21.106

XP_038958901.1

EC 3.4.21.106

XP_038958907.1

EC 3.4.21.106

XP_038958912.1

EC 3.4.21.106

XP_038958923.1

EC 3.4.21.106

XP_063138797.1

EC 3.4.21.106

XP_063138798.1

EC 3.4.21.106

XP_063138799.1

EC 3.4.21.106

XP_063138803.1

EC 3.4.21.106

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017112.1 → NP_058808.1 serine protease hepsin precursor

See identical proteins and their annotated locations for NP_058808.1

Status: PROVISIONAL

Source sequence(s)

X70900

UniProtKB/Swiss-Prot

Q05511

UniProtKB/TrEMBL

F1LS97

Related

ENSRNOP00000028644.7, ENSRNOT00000028644.8

Conserved Domains (3) summary

smart00020
Location:161 → 399

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:162 → 399

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam09272
Location:49 → 158

Hepsin-SRCR; Hepsin, SRCR

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

95464468..95480169 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039102958.2 → XP_038958886.1 serine protease hepsin isoform X1

Conserved Domains (2) summary

cd00190
Location:204 → 441

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam09272
Location:92 → 200

Hepsin-SRCR; Hepsin, SRCR
XM_063282733.1 → XP_063138803.1 serine protease hepsin isoform X4

UniProtKB/TrEMBL

F1LS97

Related

ENSRNOP00000075632.3, ENSRNOT00000079631.3
XM_063282728.1 → XP_063138798.1 serine protease hepsin isoform X2
XM_039102973.2 → XP_038958901.1 serine protease hepsin isoform X5

UniProtKB/TrEMBL

F1LS97

Conserved Domains (2) summary

cd00190
Location:204 → 441

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam09272
Location:92 → 200

Hepsin-SRCR; Hepsin, SRCR
XM_039102979.2 → XP_038958907.1 serine protease hepsin isoform X6

UniProtKB/TrEMBL

A0A8I6AHA6, F1LS97

Related

ENSRNOP00000092304.1, ENSRNOT00000117697.2

Conserved Domains (2) summary

cd00190
Location:182 → 419

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam09272
Location:70 → 178

Hepsin-SRCR; Hepsin, SRCR
XM_063282727.1 → XP_063138797.1 serine protease hepsin isoform X1
XM_063282729.1 → XP_063138799.1 serine protease hepsin isoform X3
XM_039102984.2 → XP_038958912.1 serine protease hepsin isoform X7

UniProtKB/TrEMBL

F1LS97

Conserved Domains (2) summary

cd00190
Location:204 → 391

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam09272
Location:92 → 200

Hepsin-SRCR; Hepsin, SRCR
XM_039102995.2 → XP_038958923.1 serine protease hepsin isoform X7

UniProtKB/TrEMBL

F1LS97

Conserved Domains (2) summary

cd00190
Location:204 → 391

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam09272
Location:92 → 200

Hepsin-SRCR; Hepsin, SRCR