Gatm glycine amidinotransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gatmprovided by RGD
Official Full Name: glycine amidinotransferaseprovided by RGD
Primary source: RGD:71090
See related: EnsemblRapid:ENSRNOG00000000168 AllianceGenome:RGD:71090
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: AT
Summary: Enables glycine amidinotransferase activity. Involved in several processes, including embryonic liver development; response to flavonoid; and response to mercury ion. Located in cytosol and mitochondrial inner membrane. Biomarker of acute kidney failure and kidney disease. Human ortholog(s) of this gene implicated in AGAT deficiency and Fanconi renotubular syndrome 1. Orthologous to human GATM (glycine amidinotransferase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 4695.2) and Brain (RPKM 259.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 3q35

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (130112508..130137664, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (109658919..109675508, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (114711570..114728155, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results suggest that de novo synthesis of creatine(Cr) by AGAT and GAMT, as well as cellular Cr uptake by CT1, are essential during embryonic development
Title: Creatine synthesis and transport during rat embryogenesis: spatiotemporal expression of AGAT, GAMT and CT1.

Submit: New GeneRIF Correction

General gene information

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Markers

BG377645 (e-PCR)
- UniSTS:244518

RH134360 (e-PCR)
- UniSTS:217642

RH142307 (e-PCR)
- UniSTS:231554

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables amidinotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables amidinotransferase activity	ISO Inferred from Sequence Orthology more info
enables glycine amidinotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycine amidinotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glycine amidinotransferase activity	IEA Inferred from Electronic Annotation more info
enables glycine amidinotransferase activity	ISO Inferred from Sequence Orthology more info
enables glycine amidinotransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in creatine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in creatine biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within creatine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in creatine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in embryonic liver development	IEP Inferred from Expression Pattern more info	PubMed
involved_in kidney development	IDA Inferred from Direct Assay more info	PubMed
involved_in kidney development	IEP Inferred from Expression Pattern more info	PubMed
involved_in learning or memory	IEA Inferred from Electronic Annotation more info
involved_in learning or memory	ISO Inferred from Sequence Orthology more info
involved_in muscle atrophy	IEA Inferred from Electronic Annotation more info
involved_in muscle atrophy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in response to flavonoid	IDA Inferred from Direct Assay more info	PubMed
involved_in response to mercury ion	IDA Inferred from Direct Assay more info	PubMed
involved_in response to nutrient	IDA Inferred from Direct Assay more info	PubMed
involved_in response to oxidative stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IDA Inferred from Direct Assay more info	PubMed
involved_in tissue regeneration	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial intermembrane space	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
located_in mitochondrial intermembrane space	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glycine amidinotransferase, mitochondrial

Names: L-arginine: glycine amidinotransferase; l-arginine:glycine amidinotransferase; transamidinase

NP_112293.1

EC 2.1.4.1

XP_063140701.1

EC 2.1.4.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.