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    Ylpm1 YLP motif containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299199, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ylpm1provided by RGD
    Official Full Name
    YLP motif containing 1provided by RGD
    Primary source
    RGD:1564946
    See related
    EnsemblRapid:ENSRNOG00000027317 AllianceGenome:RGD:1564946
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zap; Zap3; RGD1564946
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific. Predicted to be involved in regulation of telomere maintenance. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be located in nuclear speck. Predicted to be active in nucleus. Orthologous to human YLPM1 (YLP motif containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 95.0), Spleen (RPKM 87.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ylpm1 in Genome Data Viewer
    Location:
    6q31
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (110373371..110449578)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (104642615..104718508)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (108820774..108897209)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene apoptosis resistant E3 ubiquitin protein ligase 1 Neighboring gene Fcf1 rRNA-processing protein Neighboring gene eukaryotic translation initiation factor 2 subunit 2-like Neighboring gene U6 snRNA-associated Sm-like protein LSm5 Neighboring gene small nucleolar RNA U13 Neighboring gene U4 spliceosomal RNA Neighboring gene prospero homeobox 2 Neighboring gene dihydrolipoamide S-succinyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The nuclear PP1 interacting protein ZAP3 (ZAP) is a putative nucleoside kinase that complexes with SAM68, CIA, NF110/45, and HNRNP-G. Ulke-Lemée A, et al. Biochim Biophys Acta, 2007 Oct. PMID 17890166
    2. Proteomic characterization of protein phosphatase complexes of the mammalian nucleus. Tran HT, et al. Mol Cell Proteomics, 2004 Mar. PMID 14724321
    3. NGF gene expression and secretion in white adipose tissue: regulation in 3T3-L1 adipocytes by hormones and inflammatory cytokines. Peeraully MR, et al. Am J Physiol Endocrinol Metab, 2004 Aug. PMID 15100092
    4. A role for nucleoprotein Zap3 in the reduction of telomerase activity during embryonic stem cell differentiation. Armstrong L, et al. Mech Dev, 2004 Dec. PMID 15511642
    5. Large-scale identification of mammalian proteins localized to nuclear sub-compartments. Sutherland HG, et al. Hum Mol Genet, 2001 Sep 1. PMID 11555636

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of telomere maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    YLP motif-containing protein 1
    Names
    Nuclear protein ZAP3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271258.1 → NP_001258187.1  YLP motif-containing protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A0G2K678
      Related
      ENSRNOP00000073707.2, ENSRNOT00000080038.3
      Conserved Domains (1) summary
      pfam13671
      Location:1812 → 1947
      AAA_33; AAA domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      110373371..110449578
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112041.2 → XP_038967969.1  YLP motif-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYQ3, A0A0G2K678
      Related
      ENSRNOP00000070749.2, ENSRNOT00000089683.3
      Conserved Domains (2) summary
      PRK12678
      Location:1059 → 1208
      PRK12678; transcription termination factor Rho; Provisional
      pfam13671
      Location:1821 → 1960
      AAA_33; AAA domain

    2. XM_039112043.2 → XP_038967971.1  YLP motif-containing protein 1 isoform X2

      UniProtKB/Swiss-Prot
      P0CB49
      Conserved Domains (1) summary
      pfam13671
      Location:1116 → 1255
      AAA_33; AAA domain

    3. XM_039112044.2 → XP_038967972.1  YLP motif-containing protein 1 isoform X3

      UniProtKB/Swiss-Prot
      P0CB49
      UniProtKB/TrEMBL
      F1LQJ1
      Related
      ENSRNOP00000006492.8, ENSRNOT00000006492.9
      Conserved Domains (1) summary
      pfam13671
      Location:1107 → 1246
      AAA_33; AAA domain

    RNA

    1. XR_010052072.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CB49.1 GenPept UniProtKB/Swiss-Prot:P0CB49

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials