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    Gng5 G protein subunit gamma 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 79218, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gng5provided by RGD
    Official Full Name
    G protein subunit gamma 5provided by RGD
    Primary source
    RGD:620807
    See related
    EnsemblRapid:ENSRNOG00000084618 AllianceGenome:RGD:620807
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable G-protein beta-subunit binding activity and PDZ domain binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within positive regulation of neural precursor cell proliferation and positive regulation of secondary heart field cardioblast proliferation. Part of G-protein beta/gamma-subunit complex. Orthologous to human GNG5 (G protein subunit gamma 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 585.4), Muscle (RPKM 539.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gng5 in Genome Data Viewer
    Location:
    2q44
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (238054954..238063451)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (235394680..235403177)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (252359976..252368473)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene SSX family member 2 interacting protein Neighboring gene chitobiase Neighboring gene spermatogenesis associated 1 Neighboring gene uncharacterized LOC134485993 Neighboring gene ribosome production factor 1 Neighboring gene small ribosomal subunit protein eS12-like Neighboring gene deoxyribonuclease 2 beta Neighboring gene urate oxidase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of the cDNA and genomic sequence of a G protein gamma subunit (gamma 5). Fisher KJ, et al. Mol Cell Biol, 1992 Apr. PMID 1549114, Free PMC Article
    2. The heterotrimeric G protein subunits Gα(q) and Gβ(1) have lysophospholipase D activity. Aoyama C, et al. Biochem J, 2011 Dec 1. PMID 21812758, Free PMC Article
    3. Disruption of G-protein γ5 subtype causes embryonic lethality in mice. Moon AM, et al. PLoS One, 2014. PMID 24599258, Free PMC Article
    4. KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression. Ahmed SM, et al. J Cell Biol, 2012 Dec 10. PMID 23209302, Free PMC Article
    5. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Buschow SI, et al. Immunol Cell Biol, 2010 Nov-Dec. PMID 20458337

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G-protein beta-subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within positive regulation of neural precursor cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of secondary heart field cardioblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of G-protein beta/gamma-subunit complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
    Names
    G protein gamma-5 subunit
    guanine nucleotide binding protein (G protein), gamma 5 subunit
    guanine nucleotide binding protein gamma 5
    NP_077353.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024377.2 → NP_077353.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5

      See identical proteins and their annotated locations for NP_077353.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      P63219
      UniProtKB/TrEMBL
      F2Z3T8
      Related
      ENSRNOP00000098897.1, ENSRNOT00000162197.1
      Conserved Domains (1) summary
      cd00068
      Location:7 → 63
      GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      238054954..238063451
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P63219.1 GenPept UniProtKB/Swiss-Prot:P63219

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