Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyp2b3provided by RGD
Official Full Name: cytochrome P450, family 2, subfamily b, polypeptide 3provided by RGD
Primary source: RGD:628627
See related: EnsemblRapid:ENSRNOG00000084200 AllianceGenome:RGD:628627
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cyp2b6; CYPIIB3
Summary: Predicted to enable heme binding activity and monooxygenase activity. Involved in response to organic cyclic compound and response to xenobiotic stimulus. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; drug dependence (multiple); human immunodeficiency virus infectious disease; neonatal abstinence syndrome; and nicotine dependence. Orthologous to human CYP2B6 (cytochrome P450 family 2 subfamily B member 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 2099.3) See more
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Genomic context

Location:: 1q21

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (90780468..90859852)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (81652762..81732153)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (83163103..83236615)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D1Rat213 (e-PCR), detects polymorphism
- UniSTS:227062

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables anandamide 11,12 epoxidase activity	ISO Inferred from Sequence Orthology more info
enables anandamide 14,15 epoxidase activity	ISO Inferred from Sequence Orthology more info
enables anandamide 8,9 epoxidase activity	ISO Inferred from Sequence Orthology more info
enables arachidonate epoxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables estrogen 2-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables monooxygenase activity	TAS Traceable Author Statement more info	PubMed
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA Inferred from Biological aspect of Ancestor more info
enables testosterone 16-alpha-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables testosterone 16-beta-hydroxylase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in epoxygenase P450 pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ketone metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in steroid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic catabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cytochrome P450 2B3

Names: cytochrome P450 2B3-like; cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6; cytochrome P450IIB3

NP_775416.1

EC 1.14.14.1

XP_038958625.1

EC 1.14.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173294.3 → NP_775416.1 cytochrome P450 2B3 precursor

See identical proteins and their annotated locations for NP_775416.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

A1L121, P13107, Q3B8R5, Q64585

UniProtKB/TrEMBL

A6J997

Related

ENSRNOP00000045196.6, ENSRNOT00000047540.7

Conserved Domains (1) summary

pfam00067
Location:42 → 488

p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

90780468..90859852

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039102697.2 → XP_038958625.1 cytochrome P450 2B3 isoform X1

UniProtKB/TrEMBL

Q6LCX2

Conserved Domains (1) summary

cl41757
Location:62 → 277

cytochrome_P450; cytochrome P450 (CYP) superfamily