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    Tpm2 tropomyosin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500450, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tpm2provided by RGD
    Official Full Name
    tropomyosin 2provided by RGD
    Primary source
    RGD:1559479
    See related
    EnsemblRapid:ENSRNOG00000016731 AllianceGenome:RGD:1559479
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables actin filament binding activity; protein heterodimerization activity; and protein homodimerization activity. Predicted to be involved in actin filament organization; muscle contraction; and regulation of ATP-dependent activity. Located in actin cytoskeleton. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1A and nemaline myopathy 4. Orthologous to human TPM2 (tropomyosin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 16460.3) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tpm2 in Genome Data Viewer
    Location:
    5q22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (62566712..62576066, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (57770919..57780278, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (59016616..59025971, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 107 Neighboring gene Rho guanine nucleotide exchange factor 39 Neighboring gene carbonic anhydrase 9 Neighboring gene uncharacterized LOC134486933 Neighboring gene talin 1 Neighboring gene cAMP responsive element binding protein 3 Neighboring gene glucosylceramidase beta 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Rat embryonic fibroblast tropomyosin 1. cDNA and complete primary amino acid sequence. Yamawaki-Kataoka Y, et al. J Biol Chem, 1985 Nov 25. PMID 3840484
    2. Nonmuscle and muscle tropomyosin isoforms are expressed from a single gene by alternative RNA splicing and polyadenylation. Helfman DM, et al. Mol Cell Biol, 1986 Nov. PMID 2432392, Free PMC Article
    3. Smad4 SUMOylation is essential for memory formation through upregulation of the skeletal myopathy gene TPM2. Hsu WL, et al. BMC Biol, 2017 Nov 28. PMID 29183317, Free PMC Article
    4. In vitro formation and characterization of the skeletal muscle α·β tropomyosin heterodimers. Kalyva A, et al. Biochemistry, 2012 Aug 14. PMID 22812662, Free PMC Article
    5. Specificity of dimer formation in tropomyosins: influence of alternatively spliced exons on homodimer and heterodimer assembly. Gimona M, et al. Proc Natl Acad Sci U S A, 1995 Oct 10. PMID 7568216, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109519

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of ATP-dependent activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tropomyosin beta chain
    Names
    beta-tropomyosin
    tropomyosin 2, beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024345.2 → NP_001019516.1  tropomyosin beta chain isoform Tpm2.1sm/cy

      See identical proteins and their annotated locations for NP_001019516.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (Tpm2.1, also known as variant 2) has an alternate internal exon and an alternate 3' exon, as compared to variant Tpm2.2. The resulting isoform (Tpm2.1sm/cy, also known as isoform 2) has a different internal segment and a different C-terminus, but has the same protein size, as compared to isoform Tpm2.2st.
      Source sequence(s)
      CF110059, CV796622, FQ223760
      UniProtKB/TrEMBL
      Q5FVG5
      Related
      ENSRNOP00000044473.4, ENSRNOT00000049000.8
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 282
      Tropomyosin

    2. NM_001301235.1 → NP_001288164.1  tropomyosin beta chain isoform Tpm2.2st

      See identical proteins and their annotated locations for NP_001288164.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (Tpm2.2, also known as variant 1) represents the longer transcript and encodes isoform Tpm2.2st (also known as isoform 1), which has the same protein size as isoform Tpm2.1sm/cy.
      Source sequence(s)
      FQ118075, FQ217483, FQ223760
      UniProtKB/Swiss-Prot
      P06395, P58775
      Related
      ENSRNOP00000022801.6, ENSRNOT00000022801.8
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 282
      Tropomyosin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      62566712..62576066 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008763680.2 → XP_008761902.1  tropomyosin beta chain isoform X1

      See identical proteins and their annotated locations for XP_008761902.1

      UniProtKB/TrEMBL
      A6IJ28
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 282
      Tropomyosin

    2. XM_008763681.2 → XP_008761903.1  tropomyosin beta chain isoform X2

      See identical proteins and their annotated locations for XP_008761903.1

      Related
      ENSRNOP00000080861.1, ENSRNOT00000102327.2
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 282
      Tropomyosin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P58775.1 GenPept UniProtKB/Swiss-Prot:P58775

    Gene LinkOut

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