Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyp2b2provided by RGD
Official Full Name: cytochrome P450, family 2, subfamily b, polypeptide 2provided by RGD
Primary source: RGD:2467
See related: EnsemblRapid:ENSRNOG00000073061 AllianceGenome:RGD:2467
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cype; CYPIIB2
Summary: Enables steroid hydroxylase activity. Involved in several processes, including nicotine metabolic process; response to calcium ion; and xenobiotic metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; drug dependence (multiple); human immunodeficiency virus infectious disease; neonatal abstinence syndrome; and nicotine dependence. Orthologous to human CYP2B6 (cytochrome P450 family 2 subfamily B member 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 675.5) and Lung (RPKM 561.6) See more
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Genomic context

Location:: 1q21

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (90722243..90736272)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (81594534..81608567)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (83103925..83119578)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

stimulation of hepatic heme oxygenase-1 expression by ascorbic acid deficiency caused the decrease in CYP content in liver
Title: Ascorbic acid deficiency decreases hepatic cytochrome P-450, especially CYP2B1/2B2, and simultaneously induces heme oxygenase-1 gene expression in scurvy-prone ODS rats.
LMP2 contributes to the NO-dependent degradation of CYP2B proteins, and induction of LMP2 may be involved in the potentiation of this degradation by IL-1.
Title: Nitric oxide-dependent CYP2B degradation is potentiated by a cytokine-regulated pathway and utilizes the immunoproteasome subunit LMP2.
analysis of the spectrophotometric method to monitor the catalytic activity of microsomal cytochrome P-450 IIB1/2 and comparison with fluorometric assay
Title: A spectrophotometric method to monitor the catalytic activity of microsomal cytochrome P-450 IIB1/2: comparison with fluorometric assay.
Werner syndrome protein WRN is recruited to the CYP2B2 promoter in response to phenobarbital treatment in rat liver chromatin.
Title: Werner's syndrome helicase participates in transcription of phenobarbital-inducible CYP2B genes in rat and mouse liver.
NanoString provides an additional new technology to evaluate the induction of CYP1A1 and 2B1/2, as well as potentially other enzymes or transporters in rat liver slices.
Title: Evaluation of CYP1A1 and CYP2B1/2 m-RNA induction in rat liver slices using the NanoString technology: a novel tool for drug discovery lead optimization.
Differential induction of ethanol-metabolizing Cyp2e1 and nicotine-metabolizing Cyp2b2 in rat liver by chronic nicotine treatment and voluntary ethanol intake is reported.
Title: Differential induction of ethanol-metabolizing CYP2E1 and nicotine-metabolizing CYP2B1/2 in rat liver by chronic nicotine treatment and voluntary ethanol intake.
A greater magnitude of induction was observed in CYP2B2 than CYP2B1 in the brain cells treated with phenobarbital.
Title: Differences in the expression and inducibility of cytochrome P450 2B isoenzymes in cultured rat brain neuronal and glial cells.
Expression of cytochrome CYP2B1/2 in nonpregnant, pregnant and fetal rats exposed to tobacco smoke
Title: Expression of cytochrome CYP2B1/2 in nonpregnant, pregnant and fetal rats exposed to tobacco smoke.

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General gene information

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Markers

D1Hmgc4 (e-PCR)
- UniSTS:260688

AU046371 (e-PCR)
- UniSTS:111505

D1Wox48 (e-PCR)
- UniSTS:239557

D1Wox17 (e-PCR)
- UniSTS:119244

D1Wox70 (e-PCR)
- UniSTS:239578

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables arachidonate epoxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aromatase activity	IEA Inferred from Electronic Annotation more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA Inferred from Biological aspect of Ancestor more info
enables steroid hydroxylase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in epoxygenase P450 pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in nicotine metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to calcium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to metal ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in xenobiotic metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in xenobiotic metabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cytochrome P450 2B2

Names: cytochrome P-450b type e; cytochrome P-450e-M; cytochrome P450 PB4; cytochrome P450, subfamily IIB (phenobarbital-inducible)(b, e); cytochrome P450E

NP_001185605.1

EC 1.14.14.1

XP_038937751.1

EC 1.14.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001198676.1 → NP_001185605.1 cytochrome P450 2B2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001, M34452

UniProtKB/Swiss-Prot

P04167, Q64579, Q64582

UniProtKB/TrEMBL

A0A8I6GGX5

Related

ENSRNOP00000088265.1, ENSRNOT00000102544.2

Conserved Domains (1) summary

pfam00067
Location:48 → 496

p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

90722243..90736272

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039081823.1 → XP_038937751.1 cytochrome P450 2B2 isoform X1

UniProtKB/Swiss-Prot

P04167, Q64579, Q64582

Conserved Domains (1) summary

cd20672
Location:62 → 486

CYP2B; cytochrome P450 family 2, subfamily B