Chgb chromogranin B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Chgbprovided by RGD
Official Full Name: chromogranin Bprovided by RGD
Primary source: RGD:2339
See related: EnsemblRapid:ENSRNOG00000021269 AllianceGenome:RGD:2339
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Located in secretory granule. Orthologous to human CHGB (chromogranin B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 1136.2) and Brain (RPKM 450.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 3q36

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (140496712..140510057)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (120043824..120057169)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (125428050..125441601)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CgB is necessary for efficient trafficking of secretory proteins into the budding granule, which impacts the availability of insulin-containing secretory granules for exocytic release.
Title: Chromogranin B regulates early-stage insulin granule trafficking from the Golgi in pancreatic islet β-cells.
Possible involvement of Stat3 and Prlh1/Chgb up-regulation in the transition from short to repeated stress activation.
Title: A systems approach identifies co-signaling molecules of early growth response 1 transcription factor in immobilization stress.
When released extra-cellulary, CHGB proteolytic fragments exert a feedback effect to inhibit catecholamine secretion.
Title: Chromogranin B: intra- and extra-cellular mechanisms to regulate catecholamine storage and release, in catecholaminergic cells and organisms.
Chrombacin is a 60 residue anti-microbial neuroendocrine peptide that includes an unusual sulfotyrosine-, phosphoserine-containing motif.
Title: A sulfated, phosphorylated 7 kDa secreted peptide characterized by direct analysis of cell culture media.
Stimulation with a secretagogue mixture induced parallel release of insulin and chromogranin B from pancreatic beta cells.
Title: Beta cell chromogranin B is partially segregated in distinct granules and can be released separately from insulin in response to stimulation.
CGB is a novel regulator of cardiomyocyte InsP(3)/Ca(2+)-dependent signaling, nuclear factor kappaB activity, and brain natriuretic peptide production
Title: Chromogranin B regulates calcium signaling, nuclear factor kappaB activity, and brain natriuretic peptide production in cardiomyocytes.
CGB was localized in the nucleus; transcription control role of CGB in the nucleus
Title: Localization of the secretory granule marker protein chromogranin B in the nucleus. Potential role in transcription control.
Chromogranin B has a role in secretory granule biogenesis
Title: Chromogranin B-induced secretory granule biogenesis: comparison with the similar role of chromogranin A.

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General gene information

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Markers

UniSTS:141336 (e-PCR)
- UniSTS:141336

Chgb (e-PCR), detects polymorphism
- UniSTS:141336

RH94437 (e-PCR)
- UniSTS:119685

Gene Ontology Provided by RGD

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed
located_in secretory granule	IEA Inferred from Electronic Annotation more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: secretogranin-1

Names: Chromogranin B, parathyroid secretory protein; cgB; chromogranin B (secretogranin 1); glucagonoma peptide; secretogranin-I; sgI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.