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    Osgin1 oxidative stress induced growth inhibitor 1 [ Mus musculus (house mouse) ]

    Gene ID: 71839, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Osgin1provided by MGI
    Official Full Name
    oxidative stress induced growth inhibitor 1provided by MGI
    Primary source
    MGI:MGI:1919089
    See related
    Ensembl:ENSMUSG00000074063 AllianceGenome:MGI:1919089
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Okl38; 1700012B18Rik
    Summary
    Predicted to enable growth factor activity. Predicted to be involved in several processes, including negative regulation of cell growth; regulation of apoptotic process; and regulation of cell migration. Is expressed in central nervous system and dorsal root ganglion. Orthologous to human OSGIN1 (oxidative stress induced growth inhibitor 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in liver adult (RPKM 153.0), testis adult (RPKM 130.4) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Osgin1 in Genome Data Viewer
    Location:
    8 E1; 8 67.71 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (120160874..120172996)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (119425882..119446257)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene 45723 Neighboring gene STARR-positive B cell enhancer ABC_E3809 Neighboring gene malonyl-CoA decarboxylase Neighboring gene predicted gene, 32006 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:121947490-121947599 Neighboring gene STARR-positive B cell enhancer ABC_E2879 Neighboring gene STARR-positive B cell enhancer ABC_E10526 Neighboring gene N-terminal EF-hand calcium binding protein 2 Neighboring gene predicted gene, 53462 Neighboring gene solute carrier family 38, member 8 Neighboring gene STARR-seq mESC enhancer starr_22850

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Targeted Disruption of Mouse Dip2B Leads to Abnormal Lung Development and Prenatal Lethality. Sah RK, et al. Int J Mol Sci, 2020 Nov 3. PMID 33153107, Free PMC Article
    2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables growth factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell growth IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    oxidative stress-induced growth inhibitor 1
    Names
    pregnancy-induced growth inhibitor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027950.2 → NP_082226.1  oxidative stress-induced growth inhibitor 1

      Status: VALIDATED

      Source sequence(s)
      AC166781
      Consensus CDS
      CCDS22704.1
      UniProtKB/Swiss-Prot
      Q8VC10
      UniProtKB/TrEMBL
      Q9CVY9
      Related
      ENSMUSP00000114467.2, ENSMUST00000152420.8
      Conserved Domains (2) summary
      TIGR04018
      Location:239 → 472
      Bthiol_YpdA; putative bacillithiol system oxidoreductase, YpdA family
      cl21454
      Location:168 → 303
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RNA

    1. NR_157155.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC166781
      Related
      ENSMUST00000098365.4

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      120160874..120172996
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531377.4 → XP_006531440.1  oxidative stress-induced growth inhibitor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8VC10
      UniProtKB/TrEMBL
      Q9CVY9
      Conserved Domains (2) summary
      TIGR04018
      Location:239 → 472
      Bthiol_YpdA; putative bacillithiol system oxidoreductase, YpdA family
      cl21454
      Location:168 → 303
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. XM_006531381.5 → XP_006531444.1  oxidative stress-induced growth inhibitor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8VC10
      UniProtKB/TrEMBL
      Q9CVY9
      Conserved Domains (2) summary
      TIGR04018
      Location:239 → 472
      Bthiol_YpdA; putative bacillithiol system oxidoreductase, YpdA family
      cl21454
      Location:168 → 303
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VC10.1 GenPept UniProtKB/Swiss-Prot:Q8VC10

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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