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    ZNF33A zinc finger protein 33A [ Homo sapiens (human) ]

    Gene ID: 7581, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF33Aprovided by HGNC
    Official Full Name
    zinc finger protein 33Aprovided by HGNC
    Primary source
    HGNC:HGNC:13096
    See related
    Ensembl:ENSG00000189180 MIM:194521; AllianceGenome:HGNC:13096
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KOX2; KOX5; KOX31; NF11A; ZNF11; ZNF33; ZZAPK; ZNF11A
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 6.2), prostate (RPKM 5.2) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF33A in Genome Data Viewer
    Location:
    10p11.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (38010489..38067834)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (38054130..38111817)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (38299578..38356762)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 25 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3271 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2310 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3272 Neighboring gene ZNF25 divergent transcript Neighboring gene ReSE screen-validated silencer GRCh37_chr10:38274009-38274157 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3273 Neighboring gene RNA, U6 small nuclear 795, pseudogene Neighboring gene eukaryotic translation initiation factor 3 subunit L pseudogene 3 Neighboring gene FXYD domain containing ion transport regulator 6 pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ZNF711 puts a spell on DNA. Kooy RF. Eur J Hum Genet, 2022 Apr. PMID 35132177, Free PMC Article
    2. Genome-wide copy number variation-, validation- and screening study implicates a new copy number polymorphism associated with suicide attempts in major depressive disorder. Rao S, et al. Gene, 2020 Sep 10. PMID 32554045
    3. A novel zinc finger protein, ZZaPK, interacts with ZAK and stimulates the ZAK-expressing cells re-entering the cell cycle. Yang JJ. Biochem Biophys Res Commun, 2003 Jan 31. PMID 12535642
    4. Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution. Tunnacliffe A, et al. Nucleic Acids Res, 1993 Mar 25. PMID 8464732, Free PMC Article
    5. Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering. Huebner K, et al. Am J Hum Genet, 1991 Apr. PMID 2014798, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZNF711 puts a spell on DNA.
      Title: ZNF711 puts a spell on DNA.
    2. Genome-wide copy number variation-, validation- and screening study implicates a new copy number polymorphism associated with suicide attempts in major depressive disorder.
      Title: Genome-wide copy number variation-, validation- and screening study implicates a new copy number polymorphism associated with suicide attempts in major depressive disorder.
    3. Results suggest that ZAK might play a role as an upstream signal to suppress the ZZaPK function and decrease E2F expression.
      Title: A novel zinc finger protein, ZZaPK, interacts with ZAK and stimulates the ZAK-expressing cells re-entering the cell cycle.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ23404, KIAA0065

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 33A
    Names
    brain my041 protein
    zinc finger and ZAK-associated protein with KRAB domain
    zinc finger protein 11A
    zinc finger protein 33a (KOX 31)
    zinc finger protein KOX31

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278170.2 → NP_001265099.1  zinc finger protein 33A isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks the exon containing the translation start site and uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (c) has a longer and distinct N-terminus and lacks an aa near the C-terminus compared to isoform a.
      Source sequence(s)
      AK303445, CD679489, D31763
      Consensus CDS
      CCDS60514.1
      UniProtKB/Swiss-Prot
      Q06730
      Related
      ENSP00000485869.1, ENST00000628825.2
      Conserved Domains (5) summary
      smart00349
      Location:19 → 78
      KRAB; krueppel associated box
      COG5048
      Location:429 → 805
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:365 → 385
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:19 → 58
      KRAB; KRAB box
      pfam13465
      Location:377 → 402
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001278171.2 → NP_001265100.1  zinc finger protein 33A isoform d

      See identical proteins and their annotated locations for NP_001265100.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate exon before the last exon compared to variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (d) with a shorter N-terminus compared to isoform a. Variants 4, 6, and 10-14 all encode the same isoform (d).
      Source sequence(s)
      AK292844, AL161931, AL712670, CD679489, D31763, DB235703
      Consensus CDS
      CCDS73089.1
      UniProtKB/TrEMBL
      A0A0A0MRS1
      Conserved Domains (3) summary
      COG5048
      Location:217 → 562
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:247 → 267
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:259 → 284
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001278173.1 → NP_001265102.1  zinc finger protein 33A isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains an alternate exon in the 5' end compared to variant 1. The resulting isoform (e) initiates translation in the alternate exon, so isoform e has a longer and distinct N-terminus compared to isoform a.
      Source sequence(s)
      CD679489, D31763, DB234051, DB235703
      Consensus CDS
      CCDS73088.1
      UniProtKB/TrEMBL
      A0A0A0MR11
      Related
      ENSP00000304268.10, ENST00000307441.13
      Conserved Domains (5) summary
      smart00349
      Location:30 → 89
      KRAB; krueppel associated box
      COG5048
      Location:347 → 692
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:377 → 397
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:30 → 69
      KRAB; KRAB box
      pfam13465
      Location:389 → 414
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001278174.2 → NP_001265103.1  zinc finger protein 33A isoform d

      See identical proteins and their annotated locations for NP_001265103.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) contains an alternate exon before the last exon compared to variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (d) with a shorter N-terminus compared to isoform a. Variants 4, 6, and 10-14 all encode the same isoform (d).
      Source sequence(s)
      AL161931, CD679489, D31763, DA276183, DB235703
      Consensus CDS
      CCDS73089.1
      UniProtKB/TrEMBL
      A0A0A0MRS1
      Conserved Domains (3) summary
      COG5048
      Location:217 → 562
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:247 → 267
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:259 → 284
      zf-H2C2_2; Zinc-finger double domain

    5. NM_001278175.2 → NP_001265104.1  zinc finger protein 33A isoform f

      See identical proteins and their annotated locations for NP_001265104.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) contains an alternate exon before the last exon compared to variant 1. Translation of this variant begins in the alternate exon, so the resulting isoform (f) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AL161931, CD679489, D31763, DB134021, DB235703
      UniProtKB/Swiss-Prot
      Q06730
      Conserved Domains (3) summary
      COG5048
      Location:251 → 596
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:281 → 301
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:293 → 318
      zf-H2C2_2; Zinc-finger double domain

    6. NM_001278176.2 → NP_001265105.1  zinc finger protein 33A isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) contains an alternate exon before the last exon compared to variant 1. Translation of this variant begins at a downstream AUG compared to variant 1, so the resulting isoform (g) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AI300433, AL161931, CD679489, D31763, DB235703
      UniProtKB/Swiss-Prot
      Q06730
      Conserved Domains (3) summary
      COG5048
      Location:286 → 631
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:316 → 336
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:328 → 353
      zf-H2C2_2; Zinc-finger double domain

    7. NM_001278177.2 → NP_001265106.1  zinc finger protein 33A isoform h

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) uses an alternate splice junction at the 5' end of a coding exon compared to variant 1, that causes a frameshift. The resulting isoform (h) has a longer and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AL161931, BF435065, CD679489, D31763, DB235703
      UniProtKB/Swiss-Prot
      Q06730
      Conserved Domains (5) summary
      smart00349
      Location:33 → 92
      KRAB; krueppel associated box
      COG5048
      Location:444 → 820
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:380 → 400
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:33 → 72
      KRAB; KRAB box
      pfam13465
      Location:392 → 417
      zf-H2C2_2; Zinc-finger double domain

    8. NM_001278178.1 → NP_001265107.1  zinc finger protein 33A isoform d

      See identical proteins and their annotated locations for NP_001265107.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) uses an alternate splice junction at the 3' end of a coding exon compared to variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (d) with a shorter N-terminus compared to isoform a. Variants 4, 6, and 10-14 all encode the same isoform (d).
      Source sequence(s)
      CD679489, D31763, DA757208, DB235703
      Consensus CDS
      CCDS73089.1
      UniProtKB/TrEMBL
      A0A0A0MRS1
      Related
      ENSP00000363747.4, ENST00000374618.7
      Conserved Domains (3) summary
      COG5048
      Location:217 → 562
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:247 → 267
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:259 → 284
      zf-H2C2_2; Zinc-finger double domain

    9. NM_001278179.2 → NP_001265108.1  zinc finger protein 33A isoform d

      See identical proteins and their annotated locations for NP_001265108.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) contains an alternate exon before the last exon and uses an alternate splice junction at the 5' end of the last exon compared to variant 1. These differences cause translation initiation at a downstream AUG and results in an isoform (d) with a shorter N-terminus compared to isoform a. Variants 4, 6, and 10-14 all encode the same isoform (d).
      Source sequence(s)
      AL712670, CD679489, D31763, DB235703
      Consensus CDS
      CCDS73089.1
      UniProtKB/TrEMBL
      A0A0A0MRS1
      Conserved Domains (3) summary
      COG5048
      Location:217 → 562
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:247 → 267
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:259 → 284
      zf-H2C2_2; Zinc-finger double domain

    10. NM_001324175.2 → NP_001311104.1  zinc finger protein 33A isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12), as well as variants 4, 6, 10-11, and 13-14, encodes isoform d.
      Source sequence(s)
      AL117337, AL161931
      Consensus CDS
      CCDS73089.1
      UniProtKB/TrEMBL
      A0A0A0MRS1
      Conserved Domains (3) summary
      COG5048
      Location:217 → 562
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:247 → 267
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:259 → 284
      zf-H2C2_2; Zinc-finger double domain

    11. NM_001324176.2 → NP_001311105.1  zinc finger protein 33A isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13), as well as variants 4, 6, 10-12, and 14, encodes isoform d.
      Source sequence(s)
      AL117337, AL161931
      Consensus CDS
      CCDS73089.1
      UniProtKB/TrEMBL
      A0A0A0MRS1
      Conserved Domains (3) summary
      COG5048
      Location:217 → 562
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:247 → 267
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:259 → 284
      zf-H2C2_2; Zinc-finger double domain

    12. NM_001324177.2 → NP_001311106.1  zinc finger protein 33A isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14), as well as variants 4, 6, and 10-13, encodes isoform d.
      Source sequence(s)
      AL117337, AL161931
      Consensus CDS
      CCDS73089.1
      UniProtKB/TrEMBL
      A0A0A0MRS1
      Conserved Domains (3) summary
      COG5048
      Location:217 → 562
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:247 → 267
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:259 → 284
      zf-H2C2_2; Zinc-finger double domain

    13. NM_001324178.2 → NP_001311107.1  zinc finger protein 33A isoform i

      Status: VALIDATED

      Source sequence(s)
      AL117337, AL161931

    14. NM_006954.2 → NP_008885.1  zinc finger protein 33A isoform a

      See identical proteins and their annotated locations for NP_008885.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform a.
      Source sequence(s)
      AL161931, CD679489, D31763, DB235703
      Consensus CDS
      CCDS44372.1
      UniProtKB/Swiss-Prot
      Q06730
      Related
      ENSP00000402467.3, ENST00000432900.7
      Conserved Domains (5) summary
      smart00349
      Location:12 → 71
      KRAB; krueppel associated box
      COG5048
      Location:423 → 799
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:359 → 379
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:12 → 51
      KRAB; KRAB box
      pfam13465
      Location:371 → 396
      zf-H2C2_2; Zinc-finger double domain

    15. NM_006974.3 → NP_008905.1  zinc finger protein 33A isoform b

      See identical proteins and their annotated locations for NP_008905.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a.
      Source sequence(s)
      CD679489, D31763, DB235703
      Consensus CDS
      CCDS31182.1
      UniProtKB/Swiss-Prot
      A8K9X9, B4E0M8, F6TH33, F8WAJ5, P17013, Q06730, Q5VZ86
      Related
      ENSP00000387713.2, ENST00000458705.6
      Conserved Domains (5) summary
      smart00349
      Location:12 → 71
      KRAB; krueppel associated box
      COG5048
      Location:328 → 673
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:358 → 378
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:12 → 51
      KRAB; KRAB box
      pfam13465
      Location:370 → 395
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. NR_136709.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL117337, AL161931

    2. NR_136710.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL117337, AL161931

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      38010489..38067834
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011519650.3 → XP_011517952.1  zinc finger protein 33A isoform X3

      See identical proteins and their annotated locations for XP_011517952.1

      UniProtKB/Swiss-Prot
      Q06730
      Conserved Domains (5) summary
      smart00349
      Location:12 → 71
      KRAB; krueppel associated box
      COG5048
      Location:423 → 799
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:359 → 379
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:12 → 51
      KRAB; KRAB box
      pfam13465
      Location:371 → 396
      zf-H2C2_2; Zinc-finger double domain

    2. XM_017016617.2 → XP_016872106.1  zinc finger protein 33A isoform X1

    3. XM_011519651.3 → XP_011517953.1  zinc finger protein 33A isoform X4

      See identical proteins and their annotated locations for XP_011517953.1

      UniProtKB/Swiss-Prot
      A8K9X9, B4E0M8, F6TH33, F8WAJ5, P17013, Q06730, Q5VZ86
      Conserved Domains (5) summary
      smart00349
      Location:12 → 71
      KRAB; krueppel associated box
      COG5048
      Location:328 → 673
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:358 → 378
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:12 → 51
      KRAB; KRAB box
      pfam13465
      Location:370 → 395
      zf-H2C2_2; Zinc-finger double domain

    4. XM_011519654.3 → XP_011517956.1  zinc finger protein 33A isoform X2

      Conserved Domains (3) summary
      COG5048
      Location:250 → 595
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:280 → 300
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:292 → 317
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      38054130..38111817
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366690.1 → XP_054222665.1  zinc finger protein 33A isoform X6

    2. XM_054366689.1 → XP_054222664.1  zinc finger protein 33A isoform X5

    3. XM_054366691.1 → XP_054222666.1  zinc finger protein 33A isoform X1

    4. XM_054366692.1 → XP_054222667.1  zinc finger protein 33A isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06730.3 GenPept UniProtKB/Swiss-Prot:Q06730

    Gene LinkOut

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