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    Magea3 MAGE family member A3 [ Mus musculus (house mouse) ]

    Gene ID: 17139, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Magea3provided by MGI
    Official Full Name
    MAGE family member A3provided by MGI
    Primary source
    MGI:MGI:1333832
    See related
    Ensembl:ENSMUSG00000094196 AllianceGenome:MGI:1333832
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mage-a3
    Summary
    Predicted to enable DNA-binding transcription factor binding activity and enzyme binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in PML body; cytosol; and endoplasmic reticulum. Predicted to be active in nucleus. Is expressed in testis. Orthologous to several human genes including MAGEA10 (MAGE family member A10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward placenta adult (RPKM 1.0) See more
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    Genomic context

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    See Magea3 in Genome Data Viewer
    Location:
    X F3; X 72.38 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (153731176..153742027, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (154948180..154959031, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene claudin 34B1 Neighboring gene MAGE family member A6 Neighboring gene transmembrane and tetratricopeptide repeat containing 3 pseudogene Neighboring gene predicted gene, 25257

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MAGE cancer-testis antigens protect the mammalian germline under environmental stress. Fon Tacer K, et al. Sci Adv, 2019 May. PMID 31149633, Free PMC Article
    2. A new family of mouse genes homologous to the human MAGE genes. De Plaen E, et al. Genomics, 1999 Jan 15. PMID 9933564
    3. An overview of the MAGE gene family with the identification of all human members of the family. Chomez P, et al. Cancer Res, 2001 Jul 15. PMID 11454705
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables caspase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    melanoma antigen family A, 3
    Names
    melanoma antigen, family A, 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020017.2 → NP_064401.2  melanoma antigen family A, 3

      See identical proteins and their annotated locations for NP_064401.2

      Status: VALIDATED

      Source sequence(s)
      BC119064
      Consensus CDS
      CCDS30489.1
      UniProtKB/TrEMBL
      O89007, Q6T340
      Related
      ENSMUSP00000078793.5, ENSMUST00000079867.6
      Conserved Domains (2) summary
      pfam01454
      Location:134 → 271
      MAGE; MAGE family
      pfam12440
      Location:44 → 78
      MAGE_N; Melanoma associated antigen family N terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      153731176..153742027 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528721.1 → XP_006528784.1  melanoma antigen family A, 3 isoform X1

      See identical proteins and their annotated locations for XP_006528784.1

      UniProtKB/TrEMBL
      O89007, Q6T340
      Conserved Domains (2) summary
      pfam01454
      Location:134 → 271
      MAGE; MAGE family
      pfam12440
      Location:44 → 78
      MAGE_N; Melanoma associated antigen family N terminal

    2. XM_006528723.1 → XP_006528786.1  melanoma antigen family A, 3 isoform X1

      See identical proteins and their annotated locations for XP_006528786.1

      UniProtKB/TrEMBL
      O89007, Q6T340
      Conserved Domains (2) summary
      pfam01454
      Location:134 → 271
      MAGE; MAGE family
      pfam12440
      Location:44 → 78
      MAGE_N; Melanoma associated antigen family N terminal

    3. XM_006528722.1 → XP_006528785.1  melanoma antigen family A, 3 isoform X1

      See identical proteins and their annotated locations for XP_006528785.1

      UniProtKB/TrEMBL
      O89007, Q6T340
      Conserved Domains (2) summary
      pfam01454
      Location:134 → 271
      MAGE; MAGE family
      pfam12440
      Location:44 → 78
      MAGE_N; Melanoma associated antigen family N terminal

    4. XM_006528724.1 → XP_006528787.1  melanoma antigen family A, 3 isoform X1

      See identical proteins and their annotated locations for XP_006528787.1

      UniProtKB/TrEMBL
      O89007, Q6T340
      Conserved Domains (2) summary
      pfam01454
      Location:134 → 271
      MAGE; MAGE family
      pfam12440
      Location:44 → 78
      MAGE_N; Melanoma associated antigen family N terminal
    Nucleotide Protein Strain
    Heading Accession and Version

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