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    Serpina3b serine (or cysteine) peptidase inhibitor, clade A, member 3B [ Mus musculus (house mouse) ]

    Gene ID: 271047, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Serpina3bprovided by MGI
    Official Full Name
    serine (or cysteine) peptidase inhibitor, clade A, member 3Bprovided by MGI
    Primary source
    MGI:MGI:2182835
    See related
    Ensembl:ENSMUSG00000066364 AllianceGenome:MGI:2182835
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6A1; A030003A19Rik
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; cystic fibrosis; and vasculitis. Orthologous to human SERPINA3 (serpin family A member 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in mammary gland adult (RPKM 1.6), testis adult (RPKM 0.4) and 6 other tissues See more
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    Genomic context

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    See Serpina3b in Genome Data Viewer
    Location:
    12 E; 12 53.4 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (104094245..104105805)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (104127986..104139546)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 5 Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 3A Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 3C Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 3D, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The murine Spi-2 proteinase inhibitor locus: a multigene family with a hypervariable reactive site domain. Inglis JD, et al. EMBO J, 1991 Feb. PMID 1991447, Free PMC Article
    2. Expression patterns of murine antichymotrypsin-like genes reflect evolutionary divergence at the Serpina3 locus. Horvath AJ, et al. J Mol Evol, 2004 Oct. PMID 15638460
    3. A review and comparison of the murine alpha1-antitrypsin and alpha1-antichymotrypsin multigene clusters with the human clade A serpins. Forsyth S, et al. Genomics, 2003 Mar. PMID 12659817
    4. Update of the human and mouse SERPIN gene superfamily. Heit C, et al. Hum Genomics, 2013 Oct 30. PMID 24172014, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine protease inhibitor A3B
    Names
    alpha-1 antiproteinase
    antitrypsin
    serine (or cysteine) proteinase inhibitor, clade A, member 3B
    serpin A3B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173024.3 → NP_766612.1  serine protease inhibitor A3B precursor

      See identical proteins and their annotated locations for NP_766612.1

      Status: PROVISIONAL

      Source sequence(s)
      AC142112
      Consensus CDS
      CCDS26147.1
      UniProtKB/Swiss-Prot
      Q8BYY9
      UniProtKB/TrEMBL
      Q05A44
      Related
      ENSMUSP00000082127.3, ENSMUST00000085052.3
      Conserved Domains (1) summary
      cl00137
      Location:51 → 414
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      104094245..104105805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515931.2 → XP_006515994.1  serine protease inhibitor A3B isoform X1

      Conserved Domains (1) summary
      cd19551
      Location:37 → 403
      serpinA3_A1AC; serpin family A member 3, alpha 1-antichymotrypsin

    2. XM_017315087.2 → XP_017170576.1  serine protease inhibitor A3B isoform X2

      Conserved Domains (1) summary
      cl38926
      Location:1 → 203
      serpin; SERine Proteinase INhibitors (serpin) family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BYY9.1 GenPept UniProtKB/Swiss-Prot:Q8BYY9

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