Nuak2 NUAK family, SNF1-like kinase, 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nuak2provided by MGI
Official Full Name: NUAK family, SNF1-like kinase, 2provided by MGI
Primary source: MGI:MGI:1921387
See related: Ensembl:ENSMUSG00000009772 AllianceGenome:MGI:1921387
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Snark; Omphk2; mKIAA0537; 1200013B22Rik
Summary: Predicted to enable ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including cellular response to glucose starvation; protein phosphorylation; and regulation of hippo signaling. Is expressed in several structures, including lung; neural ectoderm; nose; paravertebral ganglion; and ventricular layer. Human ortholog(s) of this gene implicated in anencephaly. Orthologous to human NUAK2 (NUAK family kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in large intestine adult (RPKM 25.5), small intestine adult (RPKM 23.1) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 57.24 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (132243827..132261233)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (132316125..132333488)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GPR65 promotes intestinal mucosal Th1 and Th17 cell differentiation and gut inflammation through downregulating NUAK2.
Title: GPR65 promotes intestinal mucosal Th1 and Th17 cell differentiation and gut inflammation through downregulating NUAK2.
The MicroRNA miR-696 is regulated by SNARK and reduces mitochondrial activity in mouse skeletal muscle through Pgc1alpha inhibition.
Title: The MicroRNA miR-696 is regulated by SNARK and reduces mitochondrial activity in mouse skeletal muscle through Pgc1α inhibition.
NUAK2 and RCan2 participate in the p53 mutant pro-tumorigenic network.
Title: NUAK2 and RCan2 participate in the p53 mutant pro-tumorigenic network.
These results demonstrate that SNARK is highly expressed in the heart and HL1 cardiomyocytes, and that SNARK is phosphorylated in response to ischemia and exercise and functions in the regulation of cardiac glucose transport.
Title: Sucrose nonfermenting AMPK-related kinase (SNARK) regulates exercise-stimulated and ischemia-stimulated glucose transport in the heart.
A role for SNARK in the maintenance of skeletal muscle mass under cachexia conditions.
Title: Reduced sucrose nonfermenting AMPK-related kinase (SNARK) activity aggravates cancer-induced skeletal muscle wasting.
Using liver cancer as a model, NUAK2 was identified as an essential mediator of YAP-driven hepatomegaly and tumorigenesis in vivo.
Title: NUAK2 is a critical YAP target in liver cancer.
Data (including data from studies in knockout and transgenic mice) suggest that Nuak2/Snark is involved in both adipose inflammation and energy metabolism in white/brown adipocytes; Nuak2/Snark appears to regulate thermogenesis in brown adipocytes.
Title: Sucrose Nonfermenting-Related Kinase Regulates Both Adipose Inflammation and Energy Homeostasis in Mice and Humans.
These findings reveal a critical role for SNARK in myocyte survival and the maintenance of muscle mass with age.
Title: The AMPK-related kinase SNARK regulates muscle mass and myocyte survival.
NUAK1 and NUAK2 complementarily function in the apical constriction and apico-basal elongation that associate with the dorsolateral hinge point formation in cephalic neural plate during the 5- to 10-somite stages.
Title: Neural tube defects by NUAK1 and NUAK2 double mutation.
Data show that SNARK is activated by muscle contraction and is a unique mediator of contraction-stimulated glucose transport in skeletal muscle.
Title: Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Nuak2 (e-PCR), detects polymorphism
- UniSTS:527465

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucose starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to glucose starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose starvation	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein localization to nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of hippo signaling	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: NUAK family SNF1-like kinase 2

Names: SNF1/AMP-activated protein kinase; omphalocele kinase 2

NP_001181954.1

EC 2.7.11.1

NP_001403205.1

EC 2.7.11.1

NP_083054.1

EC 2.7.11.1

XP_006529972.1

EC 2.7.11.1

XP_036009854.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001195025.2 → NP_001181954.1 NUAK family SNF1-like kinase 2 isoform A

See identical proteins and their annotated locations for NP_001181954.1

Status: VALIDATED

Description

Transcript Variant: This variant (A) represents the longer transcript and encodes the longer isoform (A).

Source sequence(s)

AC160545

Consensus CDS

CCDS56642.1

UniProtKB/Swiss-Prot

Q80ZW3, Q8BZN4, Q8CIC0, Q9DBV0

Related

ENSMUSP00000072039.8, ENSMUST00000072177.14

Conserved Domains (2) summary

smart00220
Location:57 → 315

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:53 → 315

PKc_like; Protein Kinases, catalytic domain
NM_001416276.1 → NP_001403205.1 NUAK family SNF1-like kinase 2 isoform C

Status: VALIDATED

Source sequence(s)

AC160545
NM_028778.5 → NP_083054.1 NUAK family SNF1-like kinase 2 isoform B

See identical proteins and their annotated locations for NP_083054.1

Status: VALIDATED

Description

Transcript Variant: This variant (B) lacks an in-frame exon in the coding region, compared to variant A. This results in a shorter protein (isoform B), compared to isoform A.

Source sequence(s)

AC160545

Consensus CDS

CCDS15283.1

UniProtKB/Swiss-Prot

Q8BZN4

Related

ENSMUSP00000080769.6, ENSMUST00000082125.6

Conserved Domains (2) summary

smart00220
Location:57 → 307

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14161
Location:53 → 307

STKc_NUAK2; Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

132243827..132261233

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153961.1 → XP_036009854.1 NUAK family SNF1-like kinase 2 isoform X1

Conserved Domains (1) summary

cl21453
Location:1 → 208

PKc_like; Protein Kinases, catalytic domain
XM_006529909.3 → XP_006529972.1 NUAK family SNF1-like kinase 2 isoform X3

Conserved Domains (1) summary

cl21453
Location:1 → 56

PKc_like; Protein Kinases, catalytic domain