Chga chromogranin A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Chgaprovided by RGD
Official Full Name: chromogranin Aprovided by RGD
Primary source: RGD:2338
See related: EnsemblRapid:ENSRNOG00000052549 AllianceGenome:RGD:2338
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Involved in several processes, including adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation; positive regulation of signal transduction; and regulation of blood circulation. Located in chromaffin granule; extracellular space; and neuronal dense core vesicle. Biomarker of hypertension. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; end stage renal disease; hypertension; and prostate cancer. Orthologous to human CHGA (chromogranin A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 1484.6) See more
Orthologs: human mouse all
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Genomic context

Location:: 6q32

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (127460895..127472238)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (121696051..121707399)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (126434226..126445569)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

hypothesized that the 3'-UTR and promoter mutations lead to dysregulation (diminution) of Chga in brainstem cardiovascular control nuclei, ultimately contributing to the pathogenesis of hypertension in spontaneously hypertensive rats
Title: MicroRNA-22 and promoter motif polymorphisms at the Chga locus in genetic hypertension: functional and therapeutic implications for gene expression and the pathogenesis of hypertension.
Data suggest that Chga plays role in cardiocirculatory homeostasis and allostasis in hypertension; in hypertension, negative inotropic effect elicited by full-length Chga in heart may represent compensatory mechanism for increased blood pressure.
Title: Full-length human chromogranin-A cardioactivity: myocardial, coronary, and stimulus-induced processing evidence in normotensive and hypertensive male rat hearts.
CgA-dependent inducible nitric oxide synthase (iNOS) expression and stress responses in microglia involved signalling via scavenger receptors (SR).
Title: Scavenger receptor control of chromogranin A-induced microglial stress and neurotoxic cascades.
In mast cells, a chromogranin A-secretogranin III complex may play a key role in secretory granule biogenesis.
Title: Secretogranin III directs secretory vesicle biogenesis in mast cells in a manner dependent upon interaction with chromogranin A.
the rat heart the homologous rCGA1-64 fragment exerts an autocrine/paracrine modulation of myocardial and coronary performance acting as stabilizer against intense excitatory stimuli.
Title: The homologous rat chromogranin A1-64 (rCGA1-64) modulates myocardial and coronary function in rat heart to counteract adrenergic stimulation indirectly via endothelium-derived nitric oxide.
A small amount of secretogranin III is able to sort chromogranin A aggregates together with adrenomedullin to secretory granules.
Title: A large form of secretogranin III functions as a sorting receptor for chromogranin A aggregates in PC12 cells.
Cytochrome oxidase II has major implications for the role of this polypeptide in the pathogenesis of neuroendocrine cancers.
Title: Cox-2 promotes chromogranin A expression and bioactivity: evidence for a prostaglandin E2-dependent mechanism and the involvement of a proximal cyclic adenosine 5'-monophosphate-responsive element.
chromogranin A biosynthesis, proteolysis and the secretion of its derived peptides parallels that of the gonadotroph hormones throughout the oestrous cycle
Title: Chromogranin A proteolysis to generate beta-granin and WE-14 in the adenohypophysis during the rat oestrous cycle.
expression and regulation of chromogranin A in a poorly differentiated pancreatic tumor cell line
Title: Expression of chromogranin A and somatostatin receptors in pancreatic AR42J cells.
CgA and SgII (chromogranin A and secretogranin II) mRNA were expressed in both mammary adenocarcinoma and fibroadenoma tumors, but SgI (secretogranin I) mRNA was not detected in either.
Title: Expression of chromogranin/secretogranin mRNA in spontaneous mammary tumors in aging Fischer-344 rats.

Submit: New GeneRIF Correction See all GeneRIFs (15)

General gene information

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Markers

RH94856 (e-PCR)
- UniSTS:120102

RH94857 (e-PCR)
- UniSTS:120103

RH135429 (e-PCR)
- UniSTS:218706

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-negative bacterium	IEA Inferred from Electronic Annotation more info
involved_in defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-negative bacterium	ISS Inferred from Sequence or Structural Similarity more info
involved_in defense response to Gram-positive bacterium	IEA Inferred from Electronic Annotation more info
involved_in defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-positive bacterium	ISS Inferred from Sequence or Structural Similarity more info
involved_in defense response to bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in mast cell activation	ISO Inferred from Sequence Orthology more info
involved_in mast cell activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in mast cell chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in mast cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in mast cell chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in mast cell degranulation	IEA Inferred from Electronic Annotation more info
involved_in mast cell degranulation	ISO Inferred from Sequence Orthology more info
involved_in mast cell degranulation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of catecholamine secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of catecholamine secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of catecholamine secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of catecholamine secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of insulin secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in ovulation cycle	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of cAMP/PKA signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cardiac muscle contraction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of dense core granule biogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dense core granule biogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dense core granule biogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of relaxation of cardiac muscle	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of vasoconstriction	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to secretory granule	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein localization to secretory granule	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of the force of heart contraction	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in chromaffin granule	IBA Inferred from Biological aspect of Ancestor more info
located_in chromaffin granule	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal dense core vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal dense core vesicle	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed
located_in transport vesicle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: chromogranin-A

Names: cgA; chromogranin A (parathyroid secretory protein 1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.