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    Aldh1a1 aldehyde dehydrogenase 1 family, member A1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24188, updated on 4-Jan-2025

    Summary

    Symbol
    Aldh1a1provided by RGD
    Full Name
    aldehyde dehydrogenase 1 family, member A1provided by RGD
    Primary source
    RGD:2087
    See related
    EnsemblRapid:ENSRNOG00000017619 AllianceGenome:RGD:2087
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ahd2; Aldh1; Aldh2
    Summary
    Enables benzaldehyde dehydrogenase (NAD+) activity; identical protein binding activity; and retinal dehydrogenase activity. Involved in several processes, including estrous cycle; maintenance of lens transparency; and retinoic acid metabolic process. Predicted to be located in axon; cytosol; and synapse. Orthologous to human ALDH1A1 (aldehyde dehydrogenase 1 family member A1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Kidney (RPKM 2289.1), Testes (RPKM 1535.4) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Aldh1a1 in Genome Data Viewer
    Location:
    1q51
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (227426939..227579497)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (218000470..218152962)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (238222689..238264381)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene basic transcription factor 3 like 7 Neighboring gene annexin A1 Neighboring gene uncharacterized LOC134485210 Neighboring gene aldehyde dehydrogenase family 1, subfamily A7

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-chloroallyl aldehyde dehydrogenase activity  
    enables 3-chloroallyl aldehyde dehydrogenase activity  
    enables 3-chloroallyl aldehyde dehydrogenase activity PubMed 
    enables 3-deoxyglucosone dehydrogenase activity  
    enables 3-deoxyglucosone dehydrogenase activity  
    enables NAD binding PubMed 
    enables aldehyde dehydrogenase (NAD+) activity PubMed 
    enables aldehyde dehydrogenase (NAD+) activity PubMed 
    enables aldehyde dehydrogenase (NAD+) activity  
    enables aminobutyraldehyde dehydrogenase (NAD+) activity  
    enables aminobutyraldehyde dehydrogenase (NAD+) activity  
    enables aminobutyraldehyde dehydrogenase (NAD+) activity  
    enables benzaldehyde dehydrogenase (NAD+) activity  
    enables benzaldehyde dehydrogenase (NAD+) activity PubMed 
    enables identical protein binding PubMed 
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor  
    enables retinal dehydrogenase activity PubMed 
    Items 1 - 25 of 40
    Process Evidence Code Pubs
    involved_in 9-cis-retinoic acid biosynthetic process  
    acts_upstream_of_or_within 9-cis-retinoic acid biosynthetic process  
    involved_in 9-cis-retinoic acid metabolic process PubMed 
    involved_in apoptotic process  
    acts_upstream_of apoptotic process  
    involved_in cellular detoxification of aldehyde PubMed 
    involved_in cellular detoxification of aldehyde  
    acts_upstream_of_or_within embryonic eye morphogenesis  
    involved_in estrous cycle PubMed 
    involved_in fructosamine catabolic process  
    involved_in fructosamine catabolic process  
    involved_in fructose catabolic process  
    involved_in fructose catabolic process  
    involved_in gamma-aminobutyric acid biosynthetic process  
    involved_in gamma-aminobutyric acid biosynthetic process  
    involved_in gamma-aminobutyric acid biosynthetic process  
    involved_in kidney development PubMed 
    involved_in liver development PubMed 
    involved_in maintenance of lens transparency PubMed 
    involved_in midgut development PubMed 
    involved_in negative regulation of cold-induced thermogenesis  
    involved_in negative regulation of cold-induced thermogenesis  
    involved_in negative regulation of cold-induced thermogenesis PubMed 
    involved_in optic cup morphogenesis involved in camera-type eye development  
    acts_upstream_of_or_within optic cup morphogenesis involved in camera-type eye development  
    involved_in positive regulation of apoptotic process  
    acts_upstream_of_or_within positive regulation of apoptotic process  
    involved_in response to estradiol PubMed 
    involved_in response to ethanol PubMed 
    involved_in response to organic cyclic compound PubMed 
    involved_in response to oxidative stress PubMed 
    involved_in response to retinoic acid PubMed 
    involved_in response to xenobiotic stimulus  
    involved_in response to xenobiotic stimulus PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus  
    involved_in retinoic acid biosynthetic process PubMed 
    acts_upstream_of_or_within retinoic acid metabolic process  
    involved_in retinoid metabolic process PubMed 
    involved_in retinol metabolic process  
    acts_upstream_of_or_within retinol metabolic process  
    Items 1 - 25 of 40
    Component Evidence Code Pubs
    located_in axon  
    located_in axon  
    located_in axon  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in synapse  
    located_in synapse  
    located_in synapse  

    General protein information

    Preferred Names
    aldehyde dehydrogenase 1A1
    Names
    3-deoxyglucosone dehydrogenase
    ALDH-E1
    ALHDII
    RALDH 1
    aldehyde dehydrogenase 1, subfamily A1
    aldehyde dehydrogenase 2
    aldehyde dehydrogenase family 1 member A1
    aldehyde dehydrogenase family 1, subfamily A1
    aldehyde dehydrogenase, cytosolic
    ralDH1
    retinal dehydrogenase 1
    NP_071852.2
    XP_038949786.1
    XP_038949828.1
    XP_038949859.1
    XP_038949895.1
    XP_063135997.1
    XP_063136020.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022407.3NP_071852.2  aldehyde dehydrogenase 1A1

      See identical proteins and their annotated locations for NP_071852.2

      Status: PROVISIONAL

      Source sequence(s)
      AF001898
      UniProtKB/Swiss-Prot
      O09184, P51647
      UniProtKB/TrEMBL
      A0A0H2UHP1, A6I0L3
      Related
      ENSRNOP00000024000.6, ENSRNOT00000024000.8
      Conserved Domains (1) summary
      cd07141
      Location:15495
      ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      227426939..227579497
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093858.2XP_038949786.1  aldehyde dehydrogenase 1A1 isoform X1

      UniProtKB/TrEMBL
      A0A0H2UHP1, A0A8I6AP49
      Conserved Domains (1) summary
      cd07141
      Location:34514
      ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like
    2. XM_039093931.2XP_038949859.1  aldehyde dehydrogenase 1A1 isoform X2

      UniProtKB/Swiss-Prot
      O09184, P51647
      UniProtKB/TrEMBL
      A0A0H2UHP1, A6I0L3
      Conserved Domains (1) summary
      cd07141
      Location:15495
      ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like
    3. XM_039093900.2XP_038949828.1  aldehyde dehydrogenase 1A1 isoform X1

      UniProtKB/TrEMBL
      A0A0H2UHP1, A0A8I6AP49
      Conserved Domains (1) summary
      cd07141
      Location:34514
      ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like
    4. XM_063279927.1XP_063135997.1  aldehyde dehydrogenase 1A1 isoform X1

      UniProtKB/TrEMBL
      A0A0H2UHP1, A0A8I6AP49
    5. XM_063279950.1XP_063136020.1  aldehyde dehydrogenase 1A1 isoform X1

      UniProtKB/TrEMBL
      A0A0H2UHP1, A0A8I6AP49
      Related
      ENSRNOP00000090793.1, ENSRNOT00000112107.2
    6. XM_039093967.2XP_038949895.1  aldehyde dehydrogenase 1A1 isoform X2

      UniProtKB/Swiss-Prot
      O09184, P51647
      UniProtKB/TrEMBL
      A0A0H2UHP1, A6I0L3
      Conserved Domains (1) summary
      cd07141
      Location:15495
      ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like
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