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    Tox thymocyte selection-associated high mobility group box [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362481, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Toxprovided by RGD
    Official Full Name
    thymocyte selection-associated high mobility group boxprovided by RGD
    Primary source
    RGD:1310455
    See related
    EnsemblRapid:ENSRNOG00000010777 AllianceGenome:RGD:1310455
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable chromatin DNA binding activity. Predicted to be involved in several processes, including cerebral cortex neuron differentiation; lymphocyte differentiation; and regulation of positive thymic T cell selection. Predicted to act upstream of or within hematopoietic or lymphoid organ development; lymphocyte differentiation; and positive regulation of natural killer cell differentiation. Predicted to be active in nucleus. Orthologous to human TOX (thymocyte selection associated high mobility group box). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 89.7), Heart (RPKM 26.3) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tox in Genome Data Viewer
    Location:
    5q12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (24672487..24968754, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (19874994..20171272, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (19892698..20189721, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene G3BP stress granule assembly factor 1, pseudogene 2 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134478930 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene eukaryotic translation initiation factor 1, pseudogene 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TOX regulates the differentiation of human natural killer cells from hematopoietic stem cells in vitro. Yun S, et al. Immunol Lett, 2011 Apr 30. PMID 21126536
    2. TOX: an HMG box protein implicated in the regulation of thymocyte selection. Wilkinson B, et al. Nat Immunol, 2002 Mar. PMID 11850626
    3. TOX provides a link between calcineurin activation and CD8 lineage commitment. Aliahmad P, et al. J Exp Med, 2004 Apr 19. PMID 15078895, Free PMC Article
    4. Development of all CD4 T lineages requires nuclear factor TOX. Aliahmad P, et al. J Exp Med, 2008 Jan 21. PMID 18195075, Free PMC Article
    5. Tox: a multifunctional transcription factor and novel regulator of mammalian corticogenesis. Artegiani B, et al. EMBO J, 2015 Apr 1. PMID 25527292, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in CD4-positive, alpha-beta T cell lineage commitment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in CD8-positive, alpha-beta T cell lineage commitment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in NK T cell lineage commitment ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within Peyer's patch development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cerebral cortex neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leukocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lymph node development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lymphocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in natural killer cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of natural killer cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neural precursor cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of positive thymic T cell selection ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    thymocyte selection-associated high mobility group box protein TOX
    Names
    thymocyte selection-associated HMG box

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108654.1 → NP_001102124.1  thymocyte selection-associated high mobility group box protein TOX

      See identical proteins and their annotated locations for NP_001102124.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473984
      UniProtKB/TrEMBL
      A0A8I6B6M0, A6JFP6, D4A1U5
      Related
      ENSRNOP00000014661.3, ENSRNOT00000014661.5
      Conserved Domains (2) summary
      COG5648
      Location:257 → 360
      NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
      cd00084
      Location:261 → 310
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      24672487..24968754 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237844.5 → XP_006237906.1  thymocyte selection-associated high mobility group box protein TOX isoform X2

      See identical proteins and their annotated locations for XP_006237906.1

      UniProtKB/TrEMBL
      A0A8I6B6M0, A6JFP6, D4A1U5
      Related
      ENSRNOP00000098002.2, ENSRNOT00000102072.2
      Conserved Domains (2) summary
      COG5648
      Location:257 → 360
      NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
      cd00084
      Location:261 → 310
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    2. XM_017593467.3 → XP_017448956.1  thymocyte selection-associated high mobility group box protein TOX isoform X2

      UniProtKB/TrEMBL
      A0A8I6B6M0, A6JFP6, D4A1U5
      Conserved Domains (2) summary
      COG5648
      Location:257 → 360
      NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
      cd00084
      Location:261 → 310
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    3. XM_039110215.2 → XP_038966143.1  thymocyte selection-associated high mobility group box protein TOX isoform X2

      UniProtKB/TrEMBL
      A0A8I6B6M0, A6JFP6, D4A1U5
      Related
      ENSRNOP00000112043.1, ENSRNOT00000133851.1
      Conserved Domains (2) summary
      COG5648
      Location:257 → 360
      NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
      cd00084
      Location:261 → 310
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    4. XM_063287898.1 → XP_063143968.1  thymocyte selection-associated high mobility group box protein TOX isoform X1

      UniProtKB/TrEMBL
      A0A8I6AU85
      Related
      ENSRNOP00000097335.1, ENSRNOT00000099543.2
    Nucleotide Protein Strain
    Heading Accession and Version

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