Cadm1 cell adhesion molecule 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cadm1provided by RGD
Official Full Name: cell adhesion molecule 1provided by RGD
Primary source: RGD:1310999
See related: EnsemblRapid:ENSRNOG00000018778 AllianceGenome:RGD:1310999
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Igsf4; TSLC1; Igsf4a; Necl-2; SynCAM; TSLC-1; sgigsf
Summary: Enables cell adhesion molecule binding activity. Involved in liver development; negative regulation of ERBB4 signaling pathway; and negative regulation of protein phosphorylation. Located in dendrite and postsynaptic density. Biomarker of hepatocellular carcinoma and lung adenocarcinoma. Human ortholog(s) of this gene implicated in breast carcinoma and prostate cancer. Orthologous to human CADM1 (cell adhesion molecule 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Lung (RPKM 344.3), Brain (RPKM 267.2) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q23

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (56744374..57075264)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (47847836..48178703)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (51858906..52200591)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CADM1 enhances intestinal barrier function in a rat model of mild inflammatory bowel disease by inhibiting the STAT3 signaling pathway.
Title: CADM1 enhances intestinal barrier function in a rat model of mild inflammatory bowel disease by inhibiting the STAT3 signaling pathway.
proteins. Our results highlight a previously unexplored role for MPP2 at postsynaptic sites as a scaffold that links SynCAM1 cell adhesion molecules to core proteins of the postsynaptic density.
Title: MPP2 is a postsynaptic MAGUK scaffold protein that links SynCAM1 cell adhesion molecules to core components of the postsynaptic density.
miR-21 overexpression promotes cardiac fibrosis via STAT3 signaling pathway by decrease CADM1 expression, indicating miR-21 as an important signaling molecule for cardiac fibrotic remodeling and atrial fibrillation.
Title: miR-21 enhances cardiac fibrotic remodeling and fibroblast proliferation via CADM1/STAT3 pathway.
Our results suggest that, as in the CNS, CADM1 interactions drive exocytic site assembly and promote actin network formation. These results support the broader hypothesis that the effects of cell-cell contact on beta-cell maturation and function are mediated by the same extracellular protein interactions that drive the formation of the presynaptic exocytic machinery. These interactions may be therapeutic targets for re...
Title: Extracellular CADM1 interactions influence insulin secretion by rat and human islet β-cells and promote clustering of syntaxin-1.
increased CADM1 shedding appeared to contribute to the development of emphysema by generating alphaCTF and the ICD in lung epithelial cells.
Title: The intracellular domain of cell adhesion molecule 1 is present in emphysematous lungs and induces lung epithelial cell apoptosis.
SynCAM 1 acts in developing neurons to shape migrating growth cones and contributes to the adhesive differentiation of their axo-dendritic contacts
Title: SynCAM 1 participates in axo-dendritic contact assembly and shapes neuronal growth cones.
SynCAM1 mRNA levels seem to reflect the loss and restoration of synapses on motoneurons; expression of SynCAM1 and neuroligins is regulated by different mechanisms during regeneration.
Title: SynCAM1 expression correlates with restoration of central synapses on spinal motoneurons after two different models of peripheral nerve injury.
Results identify erythrocyte protein band 4.1-like 3 (protein 4.1B) as an intracellular effector molecule of Synaptic Cell Adhesion Molecule 1 (SynCAM1) that is sufficient to recruit NMDA-type receptors (NMDARs) to SynCAM1 adhesion sites in COS7 cells.
Title: SynCAM1 recruits NMDA receptors via protein 4.1B.
Our results define SynCAM proteins as components of novel heterophilic transsynaptic adhesion complexes that set up asymmetric interactions, with SynCAM proteins contributing to synapse organization and function.
Title: SynCAMs organize synapses through heterophilic adhesion.
SynCAM proteins are encoded by a family of four conserved IGSF4 genes found solely in vertebrates; transcripts can be alternatively spliced and encode proteins with three immunoglobulin-like domains.
Title: Bioinformatic characterization of the SynCAM family of immunoglobulin-like domain-containing adhesion molecules.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW529685 (e-PCR)
- UniSTS:261192

RH141584 (e-PCR)
- UniSTS:223578

d8rat63 (e-PCR)
- UniSTS:122463

RH136632 (e-PCR)
- UniSTS:210612

BF402666 (e-PCR)
- UniSTS:245946

RH126999 (e-PCR)
- UniSTS:167611

AI412733 (e-PCR)
- UniSTS:261580

RH144465 (e-PCR)
- UniSTS:233710

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables PDZ domain binding	ISS Inferred from Sequence or Structural Similarity more info
enables cell adhesion molecule binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
NOT involved_in T cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
NOT involved_in activated T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bone development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell recognition	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell recognition	ISO Inferred from Sequence Orthology more info
involved_in cell recognition	ISS Inferred from Sequence or Structural Similarity more info
involved_in detection of stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of stimulus	ISO Inferred from Sequence Orthology more info
involved_in detection of stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info
involved_in liver development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymphocyte migration into lymphoid organs	ISO Inferred from Sequence Orthology more info
involved_in maintenance of postsynaptic specialization structure	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ERBB4 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell mediated cytotoxicity	ISS Inferred from Sequence or Structural Similarity more info
involved_in presynapse assembly	ISO Inferred from Sequence Orthology more info
involved_in retrograde trans-synaptic signaling by trans-synaptic protein complex	ISO Inferred from Sequence Orthology more info
involved_in susceptibility to natural killer cell mediated cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info
involved_in susceptibility to natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in susceptibility to natural killer cell mediated cytotoxicity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in synaptic membrane adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within unidimensional cell growth	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cell adhesion molecule 1

Names: immunoglobulin superfamily, member 4; immunoglobulin superfamily, member 4A; nectin-like protein 2; spermatogenic immunoglobulin superfamily; synaptic cell adhesion molecule; tumor suppressor in lung cancer 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012201.2 → NP_001012201.1 cell adhesion molecule 1 precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

F7EYW4, Q0WXX6, Q6AYP5

UniProtKB/TrEMBL

A0A8I5Y709

Related

ENSRNOP00000076752.2, ENSRNOT00000102618.2

Conserved Domains (3) summary

cd05881
Location:49 → 143

Ig1_Necl-2; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule 2

cd05883
Location:164 → 245

Ig2_Necl-2; Second immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1))

smart00410
Location:255 → 333

IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

56744374..57075264

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006242946.5 → XP_006243008.1 cell adhesion molecule 1 isoform X3

UniProtKB/TrEMBL

A0A8I5Y709, A0A8I6GLS0

Conserved Domains (4) summary

cd05881
Location:49 → 143

Ig1_Necl-2; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1))

cd05883
Location:164 → 245

Ig2_Necl-2; Second immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1))

smart00408
Location:262 → 323

IGc2; Immunoglobulin C-2 Type

smart00410
Location:255 → 333

IG_like; Immunoglobulin like
XM_006242944.5 → XP_006243006.1 cell adhesion molecule 1 isoform X1

UniProtKB/TrEMBL

A0A5H1ZRU4, A0A8I5Y709, A6J485

Related

ENSRNOP00000041169.4, ENSRNOT00000052392.5

Conserved Domains (4) summary

cd05881
Location:49 → 143

Ig1_Necl-2; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1))

cd05883
Location:164 → 245

Ig2_Necl-2; Second immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1))

smart00408
Location:262 → 323

IGc2; Immunoglobulin C-2 Type

smart00410
Location:255 → 333

IG_like; Immunoglobulin like
XM_006242948.5 → XP_006243010.1 cell adhesion molecule 1 isoform X5

UniProtKB/TrEMBL

A0A0G2JUT1, A0A8I5Y709

Related

ENSRNOP00000100479.1, ENSRNOT00000131971.1

Conserved Domains (4) summary

cd05881
Location:49 → 143

Ig1_Necl-2; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1))

cd05883
Location:164 → 245

Ig2_Necl-2; Second immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1))

smart00408
Location:262 → 323

IGc2; Immunoglobulin C-2 Type

smart00410
Location:255 → 333

IG_like; Immunoglobulin like
XM_006242947.5 → XP_006243009.1 cell adhesion molecule 1 isoform X4

UniProtKB/TrEMBL

A0A8I5Y709, A6J487

Related

ENSRNOP00000069217.3, ENSRNOT00000079797.3

Conserved Domains (4) summary

cd05881
Location:49 → 143

Ig1_Necl-2; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1))

cd05883
Location:164 → 245

Ig2_Necl-2; Second immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1))

smart00408
Location:262 → 323

IGc2; Immunoglobulin C-2 Type

smart00410
Location:255 → 333

IG_like; Immunoglobulin like
XM_039081722.2 → XP_038937650.1 cell adhesion molecule 1 isoform X2

UniProtKB/TrEMBL

A0A8I5Y709, A6J486

Related

ENSRNOP00000081058.2, ENSRNOT00000110628.2

Conserved Domains (4) summary

smart00294
Location:400 → 418

4.1m; putative band 4.1 homologues' binding motif

smart00409
Location:255 → 333

IG; Immunoglobulin

cd05881
Location:50 → 143

IgV_1_Necl-2; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule 2; member of the V-set of Ig superfamily (IgSF) domains

cd05883
Location:144 → 242

IgI_2_Necl-2; Second immunoglobulin (Ig)-like domain of nectin-like molecule 2 (Necl-2); member of the I-set of Ig superfamily domains