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    Top2a DNA topoisomerase II alpha [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360243, updated on 4-Jan-2025

    Summary

    Official Symbol
    Top2aprovided by RGD
    Official Full Name
    DNA topoisomerase II alphaprovided by RGD
    Primary source
    RGD:62048
    See related
    EnsemblRapid:ENSRNOG00000053047 AllianceGenome:RGD:62048
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables several functions, including ATP binding activity; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; and chromatin binding activity. Involved in several processes, including DNA topological change; cerebellar cortex formation; and response to parathyroid hormone. Part of DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex. Orthologous to human TOP2A (DNA topoisomerase II alpha). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Thymus (RPKM 915.5), Spleen (RPKM 349.2) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Top2a in Genome Data Viewer
    Location:
    10q31
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (84441954..84473093, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (83945731..83976874, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (86901467..86930947, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene retinoic acid receptor, alpha Neighboring gene uncharacterized LOC120095181 Neighboring gene gap junction protein, delta 3 Neighboring gene uncharacterized LOC134480868 Neighboring gene uncharacterized LOC134480869 Neighboring gene insulin-like growth factor binding protein 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 32
    Function Evidence Code Pubs
    enables ATP binding PubMed 
    enables ATP binding  
    enables ATP binding PubMed 
    enables ATP-dependent activity, acting on DNA  
    enables DNA binding PubMed 
    enables DNA binding  
    enables DNA binding  
    enables DNA binding PubMed 
    enables DNA binding, bending  
    enables DNA binding, bending  
    enables DNA binding, bending  
    enables DNA negative supercoiling activity  
    enables DNA topoisomerase activity PubMed 
    enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity PubMed 
    enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity  
    enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity  
    enables chromatin binding PubMed 
    enables chromatin binding  
    enables chromatin binding  
    enables magnesium ion binding  
    enables magnesium ion binding  
    enables magnesium ion binding  
    enables metal ion binding  
    enables protein heterodimerization activity  
    enables protein heterodimerization activity  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables protein kinase C binding  
    enables protein kinase C binding  
    enables sequence-specific DNA binding PubMed 
    enables ubiquitin binding  
    enables ubiquitin binding  
    Items 1 - 25 of 32
    Items 1 - 25 of 41
    Process Evidence Code Pubs
    involved_in DNA damage response  
    involved_in DNA damage response  
    involved_in DNA ligation  
    involved_in DNA ligation  
    involved_in DNA topological change PubMed 
    involved_in DNA topological change  
    acts_upstream_of_or_within DNA topological change  
    involved_in DNA topological change  
    involved_in apoptotic chromosome condensation  
    involved_in apoptotic chromosome condensation  
    involved_in apoptotic chromosome condensation  
    involved_in cerebellar Purkinje cell differentiation PubMed 
    involved_in cerebellar granule cell differentiation PubMed 
    acts_upstream_of_or_within chromosome condensation  
    involved_in chromosome segregation  
    acts_upstream_of_or_within chromosome segregation  
    involved_in chromosome segregation  
    involved_in embryonic cleavage  
    acts_upstream_of_or_within embryonic cleavage  
    involved_in female meiotic nuclear division  
    involved_in female meiotic nuclear division  
    involved_in hematopoietic progenitor cell differentiation  
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation  
    involved_in negative regulation of DNA duplex unwinding  
    involved_in negative regulation of DNA duplex unwinding  
    involved_in negative regulation of DNA duplex unwinding  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of single stranded viral RNA replication via double stranded DNA intermediate  
    involved_in positive regulation of single stranded viral RNA replication via double stranded DNA intermediate  
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in regulation of circadian rhythm  
    involved_in regulation of circadian rhythm  
    involved_in regulation of circadian rhythm  
    involved_in resolution of meiotic recombination intermediates  
    involved_in response to ionizing radiation PubMed 
    involved_in response to parathyroid hormone PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    involved_in rhythmic process  
    involved_in sister chromatid segregation  
    Items 1 - 25 of 41
    Items 1 - 20 of 29
    Component Evidence Code Pubs
    part_of DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex PubMed 
    part_of DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex  
    part_of DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex  
    located_in centriole  
    located_in centriole  
    located_in chromosome, centromeric region  
    located_in chromosome, centromeric region  
    located_in condensed chromosome  
    located_in condensed chromosome  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in male germ cell nucleus  
    located_in male germ cell nucleus  
    located_in nuclear chromosome  
    located_in nuclear chromosome  
    located_in nucleolus  
    NOT located_in nucleolus  
    located_in nucleolus  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    is_active_in nucleus  
    located_in nucleus  
    part_of protein-containing complex  
    part_of ribonucleoprotein complex  
    part_of ribonucleoprotein complex  
    part_of ribonucleoprotein complex  
    Items 1 - 20 of 29

    General protein information

    Preferred Names
    DNA topoisomerase 2-alpha
    Names
    DNA topoisomerase II, alpha isozyme
    topoisomerase (DNA) 2 alpha
    topoisomerase (DNA) II alpha
    NP_001380697.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393768.1NP_001380697.1  DNA topoisomerase 2-alpha

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A0G2JWP8, A0A8I6ADA9, A6HIW1
      Related
      ENSRNOP00000091216.2, ENSRNOT00000096403.2
      Conserved Domains (2) summary
      PTZ00108
      Location:241443
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam08070
      Location:14331519
      DTHCT; DTHCT (NUC029) region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      84441954..84473093 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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