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    Ift22 intraflagellar transport 22 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288585, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ift22provided by RGD
    Official Full Name
    intraflagellar transport 22provided by RGD
    Primary source
    RGD:1305370
    See related
    EnsemblRapid:ENSRNOG00000031346 AllianceGenome:RGD:1305370
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rabl5
    Summary
    Predicted to enable GTPase activity. Predicted to be involved in intracellular protein transport. Predicted to be located in centrosome and cilium. Predicted to be part of intraciliary transport particle B. Predicted to be active in endomembrane system. Orthologous to human IFT22 (intraflagellar transport 22). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 121.7), Brain (RPKM 87.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ift22 in Genome Data Viewer
    Location:
    12q12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (25397092..25405522, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (19759072..19768859, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (22804384..22811036, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene fission, mitochondrial 1 Neighboring gene uncharacterized LOC100910802 Neighboring gene collagen type XXVI alpha 1 chain Neighboring gene myosin light chain 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The intraflagellar transport protein IFT27 promotes BBSome exit from cilia through the GTPase ARL6/BBS3. Liew GM, et al. Dev Cell, 2014 Nov 10. PMID 25443296, Free PMC Article
    2. TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella. Ishikawa H, et al. Elife, 2014 Jan 1. PMID 24596149, Free PMC Article
    3. Characterization of mouse IFT complex B. Follit JA, et al. Cell Motil Cytoskeleton, 2009 Aug. PMID 19253336, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109244

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of intraciliary transport particle B IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of intraciliary transport particle B ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of intraciliary transport particle B ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    intraflagellar transport protein 22 homolog
    Names
    RAB, member RAS oncogene family-like 5
    RAB, member of RAS oncogene family-like 5
    intraflagellar transport 22 homolog
    rab-like protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011902.1 → NP_001011902.1  intraflagellar transport protein 22 homolog

      See identical proteins and their annotated locations for NP_001011902.1

      Status: PROVISIONAL

      Source sequence(s)
      BC089940
      UniProtKB/Swiss-Prot
      Q5FVJ7
      UniProtKB/TrEMBL
      A0A8L2ULM2, A6J066
      Related
      ENSRNOP00000106755.1, ENSRNOT00000158050.1
      Conserved Domains (2) summary
      COG1100
      Location:1 → 104
      Gem1; GTPase SAR1 family domain [General function prediction only]
      cl21455
      Location:5 → 124
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      25397092..25405522 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089211.2 → XP_038945139.1  intraflagellar transport protein 22 homolog isoform X2

      UniProtKB/TrEMBL
      A6J067
      Conserved Domains (1) summary
      cl38936
      Location:5 → 66
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. XM_039089210.2 → XP_038945138.1  intraflagellar transport protein 22 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I6A2P5
      Related
      ENSRNOP00000084809.1, ENSRNOT00000098174.2
      Conserved Domains (1) summary
      cl38936
      Location:5 → 124
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. XM_039089212.2 → XP_038945140.1  intraflagellar transport protein 22 homolog isoform X3

      Conserved Domains (1) summary
      cl38936
      Location:5 → 66
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5FVJ7.1 GenPept UniProtKB/Swiss-Prot:Q5FVJ7

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