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    St3gal6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304023, updated on 27-Nov-2024

    Summary

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    Official Symbol
    St3gal6provided by RGD
    Official Full Name
    ST3 beta-galactoside alpha-2,3-sialyltransferase 6provided by RGD
    Primary source
    RGD:1303279
    See related
    EnsemblRapid:ENSRNOG00000001653 AllianceGenome:RGD:1303279
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Siat10
    Summary
    Predicted to enable N-acetyllactosaminide alpha-2,3-sialyltransferase activity. Predicted to be involved in cellular response to interleukin-6; glycolipid biosynthetic process; and protein glycosylation. Predicted to be located in Golgi membrane. Orthologous to human ST3GAL6 (ST3 beta-galactoside alpha-2,3-sialyltransferase 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 296.8), Kidney (RPKM 228.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See St3gal6 in Genome Data Viewer
    Location:
    11q12
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (55530120..55590950)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (42061282..42121801)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (44176518..44237119)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene ferritin heavy chain-like Neighboring gene ferritin domain containing 2 Neighboring gene uncharacterized LOC108352323 Neighboring gene uncharacterized LOC120095647 Neighboring gene discoidin, CUB and LCCL domain containing 2 Neighboring gene ribosomal protein S28 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of a novel alpha2,3-sialyltransferase (ST3Gal VI) that sialylates type II lactosamine structures on glycoproteins and glycolipids. Okajima T, et al. J Biol Chem, 1999 Apr 23. PMID 10206952
    2. IL-6 and IL-8 increase the expression of glycosyltransferases and sulfotransferases involved in the biosynthesis of sialylated and/or sulfated Lewisx epitopes in the human bronchial mucosa. Groux-Degroote S, et al. Biochem J, 2008 Feb 15. PMID 17944600
    3. The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach. Harduin-Lepers A, et al. Glycobiology, 2005 Aug. PMID 15843597
    4. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article
    5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N-acetyllactosaminide alpha-2,3-sialyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N-acetyllactosaminide alpha-2,3-sialyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables N-acetyllactosaminide alpha-2,3-sialyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to interleukin-6 IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to interleukin-6 ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to interleukin-6 ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glycolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycolipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycolipid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein glycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    type 2 lactosamine alpha-2,3-sialyltransferase
    Names
    CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI
    ST3Gal VI
    ST3GalVI
    sialyltransferase 10 (alpha-2,3-sialyltransferase VI)
    NP_997485.2
    XP_006248271.1
    XP_006248272.1
    XP_038944312.1
    XP_038944314.1
    XP_038944315.1
    XP_038944316.1
    XP_038944317.1
    XP_063126635.1
    XP_063126636.1
    XP_063126637.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433930.1 → NP_001420859.1  type 2 lactosamine alpha-2,3-sialyltransferase

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011

    2. NM_001433931.1 → NP_001420860.1  type 2 lactosamine alpha-2,3-sialyltransferase

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011

    3. NM_001433932.1 → NP_001420861.1  type 2 lactosamine alpha-2,3-sialyltransferase

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011

    4. NM_207602.3 → NP_997485.2  type 2 lactosamine alpha-2,3-sialyltransferase

      See identical proteins and their annotated locations for NP_997485.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      P61943
      UniProtKB/TrEMBL
      F7F9B2, Q569D2
      Conserved Domains (1) summary
      pfam00777
      Location:62 → 330
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      55530120..55590950
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270565.1 → XP_063126635.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X1

      UniProtKB/TrEMBL
      F7F9B2, Q569D2
      Related
      ENSRNOP00000002255.4, ENSRNOT00000002255.7

    2. XM_006248210.5 → XP_006248272.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X1

      UniProtKB/Swiss-Prot
      P61943
      UniProtKB/TrEMBL
      F7F9B2, Q569D2
      Conserved Domains (1) summary
      pfam00777
      Location:62 → 330
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    3. XM_063270567.1 → XP_063126637.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X4

    4. XM_006248209.5 → XP_006248271.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X1

      UniProtKB/Swiss-Prot
      P61943
      UniProtKB/TrEMBL
      F7F9B2, Q569D2
      Conserved Domains (1) summary
      pfam00777
      Location:62 → 330
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    5. XM_039088389.2 → XP_038944317.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X4

    6. XM_039088388.2 → XP_038944316.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X3

      Conserved Domains (1) summary
      pfam00777
      Location:62 → 197
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    7. XM_039088387.2 → XP_038944315.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X1

      UniProtKB/Swiss-Prot
      P61943
      UniProtKB/TrEMBL
      F7F9B2, Q569D2
      Conserved Domains (1) summary
      pfam00777
      Location:62 → 330
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    8. XM_039088384.2 → XP_038944312.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X1

      UniProtKB/Swiss-Prot
      P61943
      UniProtKB/TrEMBL
      F7F9B2, Q569D2
      Conserved Domains (1) summary
      pfam00777
      Location:62 → 330
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    9. XM_039088386.2 → XP_038944314.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X1

      UniProtKB/Swiss-Prot
      P61943
      UniProtKB/TrEMBL
      F7F9B2, Q569D2
      Conserved Domains (1) summary
      pfam00777
      Location:62 → 330
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    10. XM_063270566.1 → XP_063126636.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61943.1 GenPept UniProtKB/Swiss-Prot:P61943

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