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    Palb2 partner and localizer of BRCA2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293452, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Palb2provided by RGD
    Official Full Name
    partner and localizer of BRCA2provided by RGD
    Primary source
    RGD:1304759
    See related
    EnsemblRapid:ENSRNOG00000025126 AllianceGenome:RGD:1304759
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1304759
    Summary
    Predicted to enable DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination. Predicted to act upstream of or within several processes, including chordate embryonic development; mesoderm development; and post-anal tail morphogenesis. Predicted to be located in nuclear speck. Predicted to be part of DNA repair complex. Predicted to be active in nucleoplasm. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group N; female breast cancer; hereditary breast ovarian cancer syndrome; and pancreatic cancer. Orthologous to human PALB2 (partner and localizer of BRCA2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 37.7), Spleen (RPKM 30.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Palb2 in Genome Data Viewer
    Location:
    1q36
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (186096312..186120284, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (176665076..176689053, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (192064586..192088547, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ubiquitin family domain containing 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit AB1 Neighboring gene dynactin subunit 5 Neighboring gene polo-like kinase 1 Neighboring gene endoplasmic reticulum to nucleus signaling 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene. Jones S, et al. Science, 2009 Apr 10. PMID 19264984, Free PMC Article
    2. PALB2 regulates recombinational repair through chromatin association and oligomerization. Sy SM, et al. J Biol Chem, 2009 Jul 3. PMID 19423707, Free PMC Article
    3. Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2. Dray E, et al. Nat Struct Mol Biol, 2010 Oct. PMID 20871616, Free PMC Article
    4. Familial breast cancer and DNA repair genes: Insights into known and novel susceptibility genes from the GENESIS study, and implications for multigene panel testing. Girard E, et al. Int J Cancer, 2019 Apr 15. PMID 30303537, Free PMC Article
    5. Loss of p53 partially rescues embryonic development of Palb2 knockout mice but does not foster haploinsufficiency of Palb2 in tumour suppression. Bouwman P, et al. J Pathol, 2011 May. PMID 21404276

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within animal organ morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic organ development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within inner cell mass cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mesoderm development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within post-anal tail morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within somitogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA repair complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    partner and localizer of BRCA2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191603.1 → NP_001178532.1  partner and localizer of BRCA2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I5Y7Q7, D3ZM14
      Related
      ENSRNOP00000041446.4, ENSRNOT00000047420.7
      Conserved Domains (1) summary
      pfam16756
      Location:761 → 1108
      PALB2_WD40; Partner and localizer of BRCA2 WD40 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      186096312..186120284 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008759712.4 → XP_008757934.1  partner and localizer of BRCA2 isoform X3

      UniProtKB/TrEMBL
      A0A8I5Y7Q7
      Related
      ENSRNOP00000111776.1, ENSRNOT00000146928.1
      Conserved Domains (1) summary
      pfam16756
      Location:759 → 1084
      PALB2_WD40; Partner and localizer of BRCA2 WD40 domain

    2. XM_008759713.3 → XP_008757935.1  partner and localizer of BRCA2 isoform X4

      UniProtKB/TrEMBL
      A0A8I5Y7Q7
      Conserved Domains (1) summary
      pfam16756
      Location:761 → 1054
      PALB2_WD40; Partner and localizer of BRCA2 WD40 domain

    3. XM_039107112.2 → XP_038963040.1  partner and localizer of BRCA2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y7Q7
      Conserved Domains (1) summary
      pfam16756
      Location:761 → 1107
      PALB2_WD40; Partner and localizer of BRCA2 WD40 domain

    4. XM_008759711.4 → XP_008757933.1  partner and localizer of BRCA2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y7Q7
      Related
      ENSRNOP00000077610.2, ENSRNOT00000113438.2
      Conserved Domains (1) summary
      pfam16756
      Location:754 → 1101
      PALB2_WD40; Partner and localizer of BRCA2 WD40 domain

    RNA

    1. XR_005503165.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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